Rapid Detection of Coronavirus (COVID-19) Using Microwave Immunosensor Cavity Resonator

This paper presents a rapid diagnostic device for the detection of the pandemic coronavirus (COVID-19) using a micro-immunosensor cavity resonator. Coronavirus has been declared an international public health crisis, so it is important to design quick diagnostic methods for the detection of infected...

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Autores principales:	Dalia M. Elsheakh, Mohamed I. Ahmed, Gomaa M. Elashry, Saad M. Moghannem, Hala A. Elsadek, Waleed N. Elmazny, Nelly H. Alieldin, Esmat A. Abdallah
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	micro-immunosensor electromagnetic sensing diagnostics COVID-19 coronavirus pocket vector network analyzer (VNA) Chemical technology TP1-1185
Acceso en línea:	https://doaj.org/article/1be4e5f4236f456896f33217f8a5bf96
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spelling	oai:doaj.org-article:1be4e5f4236f456896f33217f8a5bf962021-11-11T19:03:27ZRapid Detection of Coronavirus (COVID-19) Using Microwave Immunosensor Cavity Resonator10.3390/s212170211424-8220https://doaj.org/article/1be4e5f4236f456896f33217f8a5bf962021-10-01T00:00:00Zhttps://www.mdpi.com/1424-8220/21/21/7021https://doaj.org/toc/1424-8220This paper presents a rapid diagnostic device for the detection of the pandemic coronavirus (COVID-19) using a micro-immunosensor cavity resonator. Coronavirus has been declared an international public health crisis, so it is important to design quick diagnostic methods for the detection of infected cases, especially in rural areas, to limit the spread of the virus. Herein, a proof-of-concept is presented for a portable laboratory device for the detection of the SARS-CoV-2 virus using electromagnetic biosensors. This device is a microwave cavity resonator (MCR) composed of a sensor operating at industrial, scientific and medical (ISM) 2.45 GHz inserted in 3D housing. The changes of electrical properties of measured serum samples after passing the sensor surface are presented. The three change parameters of the sensor are resonating frequency value, amplitude and phase of the reflection coefficient \|S<sub>11</sub>\|. This immune-sensor offers a portable, rapid and accurate diagnostic method for the SARS-CoV-2 virus, which can enable on-site diagnosis of infection. Medical validation for the device is performed through biostatistical analysis using the ROC (Receiver Operating Characteristic) method. The predictive accuracy of the device is 63.3% and 60.6% for reflection and phase, respectively. The device has advantages of low cost, low size and weight and rapid response. It does need a trained technician to operate it since a software program operates automatically. The device can be used at ports’ quarantine units, hospitals, etc.Dalia M. ElsheakhMohamed I. AhmedGomaa M. ElashrySaad M. MoghannemHala A. ElsadekWaleed N. ElmaznyNelly H. AlieldinEsmat A. AbdallahMDPI AGarticlemicro-immunosensorelectromagnetic sensingdiagnosticsCOVID-19coronaviruspocket vector network analyzer (VNA)Chemical technologyTP1-1185ENSensors, Vol 21, Iss 7021, p 7021 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	micro-immunosensor electromagnetic sensing diagnostics COVID-19 coronavirus pocket vector network analyzer (VNA) Chemical technology TP1-1185
spellingShingle	micro-immunosensor electromagnetic sensing diagnostics COVID-19 coronavirus pocket vector network analyzer (VNA) Chemical technology TP1-1185 Dalia M. Elsheakh Mohamed I. Ahmed Gomaa M. Elashry Saad M. Moghannem Hala A. Elsadek Waleed N. Elmazny Nelly H. Alieldin Esmat A. Abdallah Rapid Detection of Coronavirus (COVID-19) Using Microwave Immunosensor Cavity Resonator
description	This paper presents a rapid diagnostic device for the detection of the pandemic coronavirus (COVID-19) using a micro-immunosensor cavity resonator. Coronavirus has been declared an international public health crisis, so it is important to design quick diagnostic methods for the detection of infected cases, especially in rural areas, to limit the spread of the virus. Herein, a proof-of-concept is presented for a portable laboratory device for the detection of the SARS-CoV-2 virus using electromagnetic biosensors. This device is a microwave cavity resonator (MCR) composed of a sensor operating at industrial, scientific and medical (ISM) 2.45 GHz inserted in 3D housing. The changes of electrical properties of measured serum samples after passing the sensor surface are presented. The three change parameters of the sensor are resonating frequency value, amplitude and phase of the reflection coefficient \|S<sub>11</sub>\|. This immune-sensor offers a portable, rapid and accurate diagnostic method for the SARS-CoV-2 virus, which can enable on-site diagnosis of infection. Medical validation for the device is performed through biostatistical analysis using the ROC (Receiver Operating Characteristic) method. The predictive accuracy of the device is 63.3% and 60.6% for reflection and phase, respectively. The device has advantages of low cost, low size and weight and rapid response. It does need a trained technician to operate it since a software program operates automatically. The device can be used at ports’ quarantine units, hospitals, etc.
format	article
author	Dalia M. Elsheakh Mohamed I. Ahmed Gomaa M. Elashry Saad M. Moghannem Hala A. Elsadek Waleed N. Elmazny Nelly H. Alieldin Esmat A. Abdallah
author_facet	Dalia M. Elsheakh Mohamed I. Ahmed Gomaa M. Elashry Saad M. Moghannem Hala A. Elsadek Waleed N. Elmazny Nelly H. Alieldin Esmat A. Abdallah
author_sort	Dalia M. Elsheakh
title	Rapid Detection of Coronavirus (COVID-19) Using Microwave Immunosensor Cavity Resonator
title_short	Rapid Detection of Coronavirus (COVID-19) Using Microwave Immunosensor Cavity Resonator
title_full	Rapid Detection of Coronavirus (COVID-19) Using Microwave Immunosensor Cavity Resonator
title_fullStr	Rapid Detection of Coronavirus (COVID-19) Using Microwave Immunosensor Cavity Resonator
title_full_unstemmed	Rapid Detection of Coronavirus (COVID-19) Using Microwave Immunosensor Cavity Resonator
title_sort	rapid detection of coronavirus (covid-19) using microwave immunosensor cavity resonator
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/1be4e5f4236f456896f33217f8a5bf96
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Rapid Detection of Coronavirus (COVID-19) Using Microwave Immunosensor Cavity Resonator

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