Sequence features accurately predict genome-wide MeCP2 binding in vivo

MeCP2 is critical for proper brain development, and mutations in the gene encoding MeCP2 are responsible for several neurological disorders. Here, the authors show that the previously reported genome-wide preference of MeCP2 to methylated CpGs is in part due to MeCP2's affinity to GC-rich chrom...

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Autores principales:	H. Tomas Rube, Wooje Lee, Miroslav Hejna, Huaiyang Chen, Dag H. Yasui, John F. Hess, Janine M. LaSalle, Jun S. Song, Qizhi Gong
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/1be597bf744b49939e33398defbd03c2
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spelling	oai:doaj.org-article:1be597bf744b49939e33398defbd03c22021-12-02T15:34:51ZSequence features accurately predict genome-wide MeCP2 binding in vivo10.1038/ncomms110252041-1723https://doaj.org/article/1be597bf744b49939e33398defbd03c22016-03-01T00:00:00Zhttps://doi.org/10.1038/ncomms11025https://doaj.org/toc/2041-1723MeCP2 is critical for proper brain development, and mutations in the gene encoding MeCP2 are responsible for several neurological disorders. Here, the authors show that the previously reported genome-wide preference of MeCP2 to methylated CpGs is in part due to MeCP2's affinity to GC-rich chromatin.H. Tomas RubeWooje LeeMiroslav HejnaHuaiyang ChenDag H. YasuiJohn F. HessJanine M. LaSalleJun S. SongQizhi GongNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q H. Tomas Rube Wooje Lee Miroslav Hejna Huaiyang Chen Dag H. Yasui John F. Hess Janine M. LaSalle Jun S. Song Qizhi Gong Sequence features accurately predict genome-wide MeCP2 binding in vivo
description	MeCP2 is critical for proper brain development, and mutations in the gene encoding MeCP2 are responsible for several neurological disorders. Here, the authors show that the previously reported genome-wide preference of MeCP2 to methylated CpGs is in part due to MeCP2's affinity to GC-rich chromatin.
format	article
author	H. Tomas Rube Wooje Lee Miroslav Hejna Huaiyang Chen Dag H. Yasui John F. Hess Janine M. LaSalle Jun S. Song Qizhi Gong
author_facet	H. Tomas Rube Wooje Lee Miroslav Hejna Huaiyang Chen Dag H. Yasui John F. Hess Janine M. LaSalle Jun S. Song Qizhi Gong
author_sort	H. Tomas Rube
title	Sequence features accurately predict genome-wide MeCP2 binding in vivo
title_short	Sequence features accurately predict genome-wide MeCP2 binding in vivo
title_full	Sequence features accurately predict genome-wide MeCP2 binding in vivo
title_fullStr	Sequence features accurately predict genome-wide MeCP2 binding in vivo
title_full_unstemmed	Sequence features accurately predict genome-wide MeCP2 binding in vivo
title_sort	sequence features accurately predict genome-wide mecp2 binding in vivo
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/1be597bf744b49939e33398defbd03c2
work_keys_str_mv	AT htomasrube sequencefeaturesaccuratelypredictgenomewidemecp2bindinginvivo AT woojelee sequencefeaturesaccuratelypredictgenomewidemecp2bindinginvivo AT miroslavhejna sequencefeaturesaccuratelypredictgenomewidemecp2bindinginvivo AT huaiyangchen sequencefeaturesaccuratelypredictgenomewidemecp2bindinginvivo AT daghyasui sequencefeaturesaccuratelypredictgenomewidemecp2bindinginvivo AT johnfhess sequencefeaturesaccuratelypredictgenomewidemecp2bindinginvivo AT janinemlasalle sequencefeaturesaccuratelypredictgenomewidemecp2bindinginvivo AT junssong sequencefeaturesaccuratelypredictgenomewidemecp2bindinginvivo AT qizhigong sequencefeaturesaccuratelypredictgenomewidemecp2bindinginvivo
_version_	1718386703535702016

Sequence features accurately predict genome-wide MeCP2 binding in vivo

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