Neuronal let-7b-5p acts through the Hippo-YAP pathway in neonatal encephalopathy

Using next generation sequencing of dried blood spots and subsequent validation, Ponnusamy et al identify let-7b-5p as an elevated microRNA in neonates with moderate to severe encephalopathy. Using cell culture and murine models of perinatal brain injury they demonstrate that the effects of let-7b-5...

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Autores principales:	Vennila Ponnusamy, Richard T. H. Ip, Moumin A. E. K. Mohamed, Paul Clarke, Eva Wozniak, Charles Mein, Leslie Schwendimann, Akif Barlas, Philippa Chisholm, Ela Chakkarapani, Adina T. Michael-Titus, Pierre Gressens, Ping K. Yip, Divyen K. Shah
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/1be6bfbde1764c6a85fd37f7b2291c5b
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spelling	oai:doaj.org-article:1be6bfbde1764c6a85fd37f7b2291c5b2021-12-02T17:17:37ZNeuronal let-7b-5p acts through the Hippo-YAP pathway in neonatal encephalopathy10.1038/s42003-021-02672-32399-3642https://doaj.org/article/1be6bfbde1764c6a85fd37f7b2291c5b2021-09-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02672-3https://doaj.org/toc/2399-3642Using next generation sequencing of dried blood spots and subsequent validation, Ponnusamy et al identify let-7b-5p as an elevated microRNA in neonates with moderate to severe encephalopathy. Using cell culture and murine models of perinatal brain injury they demonstrate that the effects of let-7b-5p are elicited via the Hippo-YAP pathway, which should be validated in large neonate cohorts to expand our understanding of let-7b-5p as a biomarker for neonatal encephalopathy.Vennila PonnusamyRichard T. H. IpMoumin A. E. K. MohamedPaul ClarkeEva WozniakCharles MeinLeslie SchwendimannAkif BarlasPhilippa ChisholmEla ChakkarapaniAdina T. Michael-TitusPierre GressensPing K. YipDivyen K. ShahNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Vennila Ponnusamy Richard T. H. Ip Moumin A. E. K. Mohamed Paul Clarke Eva Wozniak Charles Mein Leslie Schwendimann Akif Barlas Philippa Chisholm Ela Chakkarapani Adina T. Michael-Titus Pierre Gressens Ping K. Yip Divyen K. Shah Neuronal let-7b-5p acts through the Hippo-YAP pathway in neonatal encephalopathy
description	Using next generation sequencing of dried blood spots and subsequent validation, Ponnusamy et al identify let-7b-5p as an elevated microRNA in neonates with moderate to severe encephalopathy. Using cell culture and murine models of perinatal brain injury they demonstrate that the effects of let-7b-5p are elicited via the Hippo-YAP pathway, which should be validated in large neonate cohorts to expand our understanding of let-7b-5p as a biomarker for neonatal encephalopathy.
format	article
author	Vennila Ponnusamy Richard T. H. Ip Moumin A. E. K. Mohamed Paul Clarke Eva Wozniak Charles Mein Leslie Schwendimann Akif Barlas Philippa Chisholm Ela Chakkarapani Adina T. Michael-Titus Pierre Gressens Ping K. Yip Divyen K. Shah
author_facet	Vennila Ponnusamy Richard T. H. Ip Moumin A. E. K. Mohamed Paul Clarke Eva Wozniak Charles Mein Leslie Schwendimann Akif Barlas Philippa Chisholm Ela Chakkarapani Adina T. Michael-Titus Pierre Gressens Ping K. Yip Divyen K. Shah
author_sort	Vennila Ponnusamy
title	Neuronal let-7b-5p acts through the Hippo-YAP pathway in neonatal encephalopathy
title_short	Neuronal let-7b-5p acts through the Hippo-YAP pathway in neonatal encephalopathy
title_full	Neuronal let-7b-5p acts through the Hippo-YAP pathway in neonatal encephalopathy
title_fullStr	Neuronal let-7b-5p acts through the Hippo-YAP pathway in neonatal encephalopathy
title_full_unstemmed	Neuronal let-7b-5p acts through the Hippo-YAP pathway in neonatal encephalopathy
title_sort	neuronal let-7b-5p acts through the hippo-yap pathway in neonatal encephalopathy
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/1be6bfbde1764c6a85fd37f7b2291c5b
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Neuronal let-7b-5p acts through the Hippo-YAP pathway in neonatal encephalopathy

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