Effect of folic acid supplementation on cardiovascular outcomes: a systematic review and meta-analysis.

<h4>Background</h4>Folic acid is widely used to lower homocysteine concentrations and prevent adverse cardiovascular outcomes. However, the effect of folic acid on cardiovascular events is not clear at the present time. We carried out a comprehensive systematic review and meta-analysis t...

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Autores principales:	Yu-Hao Zhou, Jian-Yuan Tang, Mei-Jing Wu, Jian Lu, Xin Wei, Ying-Yi Qin, Chao Wang, Jin-Fang Xu, Jia He
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2011
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/1beaf3ddfaa04c4cbcf607be3e7a9881
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spelling	oai:doaj.org-article:1beaf3ddfaa04c4cbcf607be3e7a98812021-12-02T20:11:43ZEffect of folic acid supplementation on cardiovascular outcomes: a systematic review and meta-analysis.1932-620310.1371/journal.pone.0025142https://doaj.org/article/1beaf3ddfaa04c4cbcf607be3e7a98812011-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21980387/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Folic acid is widely used to lower homocysteine concentrations and prevent adverse cardiovascular outcomes. However, the effect of folic acid on cardiovascular events is not clear at the present time. We carried out a comprehensive systematic review and meta-analysis to assess the effects of folic acid supplementation on cardiovascular outcomes.<h4>Methodology and principal findings</h4>We systematically searched Medline, EmBase, the Cochrane Central Register of Controlled Trials, reference lists of articles, and proceedings of major meetings for relevant literature. We included randomized placebo-controlled trials that reported on the effects of folic acid on cardiovascular events compared to placebo. Of 1594 identified studies, we included 16 trials reporting data on 44841 patients. These studies reported 8238 major cardiovascular events, 2001 strokes, 2917 myocardial infarctions, and 6314 deaths. Folic acid supplementation as compared to placebo had no effect on major cardiovascular events (RR, 0.98; 95% CI, 0.93-1.04), stroke (RR, 0.89; 95% CI,0.78-1.01), myocardial infarction (RR, 1.00; 95% CI, 0.93-1.07), or deaths from any cause (RR, 1.00;95% CI, 0.96-1.05). Moreover, folic acid as compared to placebo also had no effect on the following secondary outcomes: risk of revascularization (RR, 1.05; 95%CI, 0.95-1.16), acute coronary syndrome (RR, 1.06; 95%CI, 0.97-1.15), cancer (RR, 1.08; 95%CI, 0.98-1.21), vascular death (RR, 0.94; 95%CI,0.88-1.02), or non-vascular death (RR, 1.06; 95%CI, 0.97-1.15).<h4>Conclusion/significance</h4>Folic acid supplementation does not effect on the incidence of major cardiovascular events, stroke, myocardial infarction or all cause mortality.Yu-Hao ZhouJian-Yuan TangMei-Jing WuJian LuXin WeiYing-Yi QinChao WangJin-Fang XuJia HePublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 6, Iss 9, p e25142 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yu-Hao Zhou Jian-Yuan Tang Mei-Jing Wu Jian Lu Xin Wei Ying-Yi Qin Chao Wang Jin-Fang Xu Jia He Effect of folic acid supplementation on cardiovascular outcomes: a systematic review and meta-analysis.
description	<h4>Background</h4>Folic acid is widely used to lower homocysteine concentrations and prevent adverse cardiovascular outcomes. However, the effect of folic acid on cardiovascular events is not clear at the present time. We carried out a comprehensive systematic review and meta-analysis to assess the effects of folic acid supplementation on cardiovascular outcomes.<h4>Methodology and principal findings</h4>We systematically searched Medline, EmBase, the Cochrane Central Register of Controlled Trials, reference lists of articles, and proceedings of major meetings for relevant literature. We included randomized placebo-controlled trials that reported on the effects of folic acid on cardiovascular events compared to placebo. Of 1594 identified studies, we included 16 trials reporting data on 44841 patients. These studies reported 8238 major cardiovascular events, 2001 strokes, 2917 myocardial infarctions, and 6314 deaths. Folic acid supplementation as compared to placebo had no effect on major cardiovascular events (RR, 0.98; 95% CI, 0.93-1.04), stroke (RR, 0.89; 95% CI,0.78-1.01), myocardial infarction (RR, 1.00; 95% CI, 0.93-1.07), or deaths from any cause (RR, 1.00;95% CI, 0.96-1.05). Moreover, folic acid as compared to placebo also had no effect on the following secondary outcomes: risk of revascularization (RR, 1.05; 95%CI, 0.95-1.16), acute coronary syndrome (RR, 1.06; 95%CI, 0.97-1.15), cancer (RR, 1.08; 95%CI, 0.98-1.21), vascular death (RR, 0.94; 95%CI,0.88-1.02), or non-vascular death (RR, 1.06; 95%CI, 0.97-1.15).<h4>Conclusion/significance</h4>Folic acid supplementation does not effect on the incidence of major cardiovascular events, stroke, myocardial infarction or all cause mortality.
format	article
author	Yu-Hao Zhou Jian-Yuan Tang Mei-Jing Wu Jian Lu Xin Wei Ying-Yi Qin Chao Wang Jin-Fang Xu Jia He
author_facet	Yu-Hao Zhou Jian-Yuan Tang Mei-Jing Wu Jian Lu Xin Wei Ying-Yi Qin Chao Wang Jin-Fang Xu Jia He
author_sort	Yu-Hao Zhou
title	Effect of folic acid supplementation on cardiovascular outcomes: a systematic review and meta-analysis.
title_short	Effect of folic acid supplementation on cardiovascular outcomes: a systematic review and meta-analysis.
title_full	Effect of folic acid supplementation on cardiovascular outcomes: a systematic review and meta-analysis.
title_fullStr	Effect of folic acid supplementation on cardiovascular outcomes: a systematic review and meta-analysis.
title_full_unstemmed	Effect of folic acid supplementation on cardiovascular outcomes: a systematic review and meta-analysis.
title_sort	effect of folic acid supplementation on cardiovascular outcomes: a systematic review and meta-analysis.
publisher	Public Library of Science (PLoS)
publishDate	2011
url	https://doaj.org/article/1beaf3ddfaa04c4cbcf607be3e7a9881
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Effect of folic acid supplementation on cardiovascular outcomes: a systematic review and meta-analysis.

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