Electrophysiological evidence for pre-attention information processing improvement in patients with central hemiplegic after peripheral nerve rewiring: a pilot study

Abstract Central neurologic injury (CNI) causes dysfunctions not only in limbs but also in cognitive ability. We applied a novel peripheral nerve rewiring (PNR) surgical procedure to restore limb function. Here, we conducted a prospective study to develop estimates for the extent of preattentive pro...

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Autores principales:	Tie Li, Xu-Yun Hua, Mou-Xiong Zheng, Yu-Lan Zhu, Yan-Qun Qiu, Yun-Dong Shen, Jian-Guang Xu, Yu-Dong Gu, Wen-Dong Xu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/1beaf8680e844b4bbf1926fbdd2bc142
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spelling	oai:doaj.org-article:1beaf8680e844b4bbf1926fbdd2bc1422021-12-02T12:30:12ZElectrophysiological evidence for pre-attention information processing improvement in patients with central hemiplegic after peripheral nerve rewiring: a pilot study10.1038/s41598-017-07263-z2045-2322https://doaj.org/article/1beaf8680e844b4bbf1926fbdd2bc1422017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-07263-zhttps://doaj.org/toc/2045-2322Abstract Central neurologic injury (CNI) causes dysfunctions not only in limbs but also in cognitive ability. We applied a novel peripheral nerve rewiring (PNR) surgical procedure to restore limb function. Here, we conducted a prospective study to develop estimates for the extent of preattentive processes to cognitive function changes in CNI patients after PNR. Auditory mismatch negativity (MMN) was measured in CNI patients who received the PNR surgery plus conventional rehabilitation treatment. During the 2-year follow-up, the MMN was enhanced with increased amplitude in the PNR plus rehabilitation group compared to the rehabilitation-only group as the experiment progressed, and progressive improvement in behavioural examination tests was also observed. Furthermore, we found a significant correlation between the changes in Fugl-Meyer assessment scale scores and in MMN amplitudes. These results suggested that PNR could affect the efficiency of pre-attention information processing synchronously with the recovery of motor function in the paralyzed arm of the in chronic CNI patients. Such electroencephalographic measures might provide a biological approach with which to distinguish patient subgroups after surgery, and the change in MMN may serve as an objective auxiliary index, indicating the degree of motor recovery and brain cognitive function.Tie LiXu-Yun HuaMou-Xiong ZhengYu-Lan ZhuYan-Qun QiuYun-Dong ShenJian-Guang XuYu-Dong GuWen-Dong XuNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Tie Li Xu-Yun Hua Mou-Xiong Zheng Yu-Lan Zhu Yan-Qun Qiu Yun-Dong Shen Jian-Guang Xu Yu-Dong Gu Wen-Dong Xu Electrophysiological evidence for pre-attention information processing improvement in patients with central hemiplegic after peripheral nerve rewiring: a pilot study
description	Abstract Central neurologic injury (CNI) causes dysfunctions not only in limbs but also in cognitive ability. We applied a novel peripheral nerve rewiring (PNR) surgical procedure to restore limb function. Here, we conducted a prospective study to develop estimates for the extent of preattentive processes to cognitive function changes in CNI patients after PNR. Auditory mismatch negativity (MMN) was measured in CNI patients who received the PNR surgery plus conventional rehabilitation treatment. During the 2-year follow-up, the MMN was enhanced with increased amplitude in the PNR plus rehabilitation group compared to the rehabilitation-only group as the experiment progressed, and progressive improvement in behavioural examination tests was also observed. Furthermore, we found a significant correlation between the changes in Fugl-Meyer assessment scale scores and in MMN amplitudes. These results suggested that PNR could affect the efficiency of pre-attention information processing synchronously with the recovery of motor function in the paralyzed arm of the in chronic CNI patients. Such electroencephalographic measures might provide a biological approach with which to distinguish patient subgroups after surgery, and the change in MMN may serve as an objective auxiliary index, indicating the degree of motor recovery and brain cognitive function.
format	article
author	Tie Li Xu-Yun Hua Mou-Xiong Zheng Yu-Lan Zhu Yan-Qun Qiu Yun-Dong Shen Jian-Guang Xu Yu-Dong Gu Wen-Dong Xu
author_facet	Tie Li Xu-Yun Hua Mou-Xiong Zheng Yu-Lan Zhu Yan-Qun Qiu Yun-Dong Shen Jian-Guang Xu Yu-Dong Gu Wen-Dong Xu
author_sort	Tie Li
title	Electrophysiological evidence for pre-attention information processing improvement in patients with central hemiplegic after peripheral nerve rewiring: a pilot study
title_short	Electrophysiological evidence for pre-attention information processing improvement in patients with central hemiplegic after peripheral nerve rewiring: a pilot study
title_full	Electrophysiological evidence for pre-attention information processing improvement in patients with central hemiplegic after peripheral nerve rewiring: a pilot study
title_fullStr	Electrophysiological evidence for pre-attention information processing improvement in patients with central hemiplegic after peripheral nerve rewiring: a pilot study
title_full_unstemmed	Electrophysiological evidence for pre-attention information processing improvement in patients with central hemiplegic after peripheral nerve rewiring: a pilot study
title_sort	electrophysiological evidence for pre-attention information processing improvement in patients with central hemiplegic after peripheral nerve rewiring: a pilot study
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/1beaf8680e844b4bbf1926fbdd2bc142
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Electrophysiological evidence for pre-attention information processing improvement in patients with central hemiplegic after peripheral nerve rewiring: a pilot study

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