Tracheitis Caused by Coinfection with Cytomegalovirus and Herpes Simplex Virus

Clinically significant isolated viral tracheitis is scarce in adults, and upper airway obstruction caused by viral tracheitis is even more infrequent. A 74-year-old woman, who was administered low-dose steroids for two months for chronic obstructive pulmonary disease (COPD), developed dyspnea with s...

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Autores principales:	Yu-Mi Lee, So-Woon Kim, Won-Gun Kwack
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	cytomegalovirus herpes simplex virus tracheitis Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/1beca484e8284d93a45774383097df70
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spelling	oai:doaj.org-article:1beca484e8284d93a45774383097df702021-11-25T18:18:12ZTracheitis Caused by Coinfection with Cytomegalovirus and Herpes Simplex Virus10.3390/medicina571111621648-91441010-660Xhttps://doaj.org/article/1beca484e8284d93a45774383097df702021-10-01T00:00:00Zhttps://www.mdpi.com/1648-9144/57/11/1162https://doaj.org/toc/1010-660Xhttps://doaj.org/toc/1648-9144Clinically significant isolated viral tracheitis is scarce in adults, and upper airway obstruction caused by viral tracheitis is even more infrequent. A 74-year-old woman, who was administered low-dose steroids for two months for chronic obstructive pulmonary disease (COPD), developed dyspnea with stridor and required mechanical ventilation for respiratory failure. Chest computed tomography showed a diffuse tracheal wall thickening with luminal narrowing and peribronchial consolidation in the right upper lobe. Bronchoscopy revealed a proximal tracheal narrowing with multiple ulcerations of the tracheal mucosa surrounded by an erythematous margin. Pathologic examinations of the tracheal mucosal tissue, including immunohistochemistry, revealed a cytomegalovirus (CMV) and herpes simplex virus (HSV) infection. Furthermore, the bronchial alveolar lavage fluid was positive on the CMV real-time polymerase chain reaction. The patient was treated with intravenous ganciclovir for 44 days. The follow-up bronchoscopy 49 days after the initiation of ganciclovir revealed improved multiple ulcerations with scars. We report a rare case of tracheitis caused by coinfection with CMV and HSV in a patient with COPD who had been taking low-dose steroids for months. The case showed that CMV and HSV are potential causes of serious tracheitis and respiratory failure.Yu-Mi LeeSo-Woon KimWon-Gun KwackMDPI AGarticlecytomegalovirusherpes simplex virustracheitisMedicine (General)R5-920ENMedicina, Vol 57, Iss 1162, p 1162 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	cytomegalovirus herpes simplex virus tracheitis Medicine (General) R5-920
spellingShingle	cytomegalovirus herpes simplex virus tracheitis Medicine (General) R5-920 Yu-Mi Lee So-Woon Kim Won-Gun Kwack Tracheitis Caused by Coinfection with Cytomegalovirus and Herpes Simplex Virus
description	Clinically significant isolated viral tracheitis is scarce in adults, and upper airway obstruction caused by viral tracheitis is even more infrequent. A 74-year-old woman, who was administered low-dose steroids for two months for chronic obstructive pulmonary disease (COPD), developed dyspnea with stridor and required mechanical ventilation for respiratory failure. Chest computed tomography showed a diffuse tracheal wall thickening with luminal narrowing and peribronchial consolidation in the right upper lobe. Bronchoscopy revealed a proximal tracheal narrowing with multiple ulcerations of the tracheal mucosa surrounded by an erythematous margin. Pathologic examinations of the tracheal mucosal tissue, including immunohistochemistry, revealed a cytomegalovirus (CMV) and herpes simplex virus (HSV) infection. Furthermore, the bronchial alveolar lavage fluid was positive on the CMV real-time polymerase chain reaction. The patient was treated with intravenous ganciclovir for 44 days. The follow-up bronchoscopy 49 days after the initiation of ganciclovir revealed improved multiple ulcerations with scars. We report a rare case of tracheitis caused by coinfection with CMV and HSV in a patient with COPD who had been taking low-dose steroids for months. The case showed that CMV and HSV are potential causes of serious tracheitis and respiratory failure.
format	article
author	Yu-Mi Lee So-Woon Kim Won-Gun Kwack
author_facet	Yu-Mi Lee So-Woon Kim Won-Gun Kwack
author_sort	Yu-Mi Lee
title	Tracheitis Caused by Coinfection with Cytomegalovirus and Herpes Simplex Virus
title_short	Tracheitis Caused by Coinfection with Cytomegalovirus and Herpes Simplex Virus
title_full	Tracheitis Caused by Coinfection with Cytomegalovirus and Herpes Simplex Virus
title_fullStr	Tracheitis Caused by Coinfection with Cytomegalovirus and Herpes Simplex Virus
title_full_unstemmed	Tracheitis Caused by Coinfection with Cytomegalovirus and Herpes Simplex Virus
title_sort	tracheitis caused by coinfection with cytomegalovirus and herpes simplex virus
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/1beca484e8284d93a45774383097df70
work_keys_str_mv	AT yumilee tracheitiscausedbycoinfectionwithcytomegalovirusandherpessimplexvirus AT sowoonkim tracheitiscausedbycoinfectionwithcytomegalovirusandherpessimplexvirus AT wongunkwack tracheitiscausedbycoinfectionwithcytomegalovirusandherpessimplexvirus
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Tracheitis Caused by Coinfection with Cytomegalovirus and Herpes Simplex Virus

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