Immunohistochemical Evaluation and Clinicopathological Correlation of Mer and Axl Tyrosine Kinase TAM Receptors in Cutaneous Melanoma

Background: Malignant melanoma (MM) is potentially the most dangerous form of skin tumor. In the last few years, the so-called TAM receptors, a unique family of tyrosine kinase (TK) receptors, have become increasingly important. Objectives: To evaluate Mer and Axl TAM receptor expression to find...

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Autores principales:	Andrea Pontara, Giovanni Paolino, Vanesa Gregorc, Santo Raffaele Mercuri, Alessandra Bulotta, Pietro Bearzi, Claudio Doglioni, Nathalie Rizzo
Formato:	article
Lenguaje:	EN
Publicado:	Mattioli1885 2020
Materias:	malignant melanoma tyrosine kinase Mer Axl receptors therapy Dermatology RL1-803
Acceso en línea:	https://doaj.org/article/1befc1b484724b5b89c45d67773b3db1
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spelling	oai:doaj.org-article:1befc1b484724b5b89c45d67773b3db12021-11-17T08:28:53ZImmunohistochemical Evaluation and Clinicopathological Correlation of Mer and Axl Tyrosine Kinase TAM Receptors in Cutaneous Melanoma10.5826/dpc.1002a292160-9381https://doaj.org/article/1befc1b484724b5b89c45d67773b3db12020-04-01T00:00:00Zhttp://dpcj.org/index.php/dpc/article/view/1042https://doaj.org/toc/2160-9381 Background: Malignant melanoma (MM) is potentially the most dangerous form of skin tumor. In the last few years, the so-called TAM receptors, a unique family of tyrosine kinase (TK) receptors, have become increasingly important. Objectives: To evaluate Mer and Axl TAM receptor expression to find clinicopathological features that could explain the biological behavior of MM. Patients and Methods: Clinicopathological data were obtained from an MM electronic database at our Institute. We reviewed 24 cutaneous MM specimens. TAM receptor expression was assayed using immunohistochemistry. Combinative semiquantitative scoring was used for the evaluation of TAM receptor expression (MerTK and AxlTK). Appropriate statistical methods were used to evaluate a possible correlation between TAM receptor expression and the clinicopathological variables of the MM samples (univariate analysis and multivariate analysis). Results: MerTK and AxlTK were expressed differently in the MM samples, with a major expression of the first receptor. The cells of the tumor microenvironment contributed to the majority of the total score. A significant association was found between AxlScore and the site of the tumor and between AxlScore and the variable ulceration; another correlation was found between MerScore and the following characteristics: pathological stage of the tumor (pT), sex, ulceration, and tumor-infiltrating lymphocytes. Conclusions: All correlations between the expression of MerTK and AxlTK with the clinical and histological variables of MM should be validated in a large group of people in order to increase the validity and the impact of our observations, with subsequently therapeutic implications in the era of the “targeted therapy.” Andrea PontaraGiovanni PaolinoVanesa GregorcSanto Raffaele MercuriAlessandra BulottaPietro BearziClaudio DoglioniNathalie RizzoMattioli1885articlemalignant melanomatyrosine kinaseMerAxlreceptorstherapyDermatologyRL1-803ENDermatology Practical & Conceptual, Vol 10, Iss 2 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	malignant melanoma tyrosine kinase Mer Axl receptors therapy Dermatology RL1-803
spellingShingle	malignant melanoma tyrosine kinase Mer Axl receptors therapy Dermatology RL1-803 Andrea Pontara Giovanni Paolino Vanesa Gregorc Santo Raffaele Mercuri Alessandra Bulotta Pietro Bearzi Claudio Doglioni Nathalie Rizzo Immunohistochemical Evaluation and Clinicopathological Correlation of Mer and Axl Tyrosine Kinase TAM Receptors in Cutaneous Melanoma
description	Background: Malignant melanoma (MM) is potentially the most dangerous form of skin tumor. In the last few years, the so-called TAM receptors, a unique family of tyrosine kinase (TK) receptors, have become increasingly important. Objectives: To evaluate Mer and Axl TAM receptor expression to find clinicopathological features that could explain the biological behavior of MM. Patients and Methods: Clinicopathological data were obtained from an MM electronic database at our Institute. We reviewed 24 cutaneous MM specimens. TAM receptor expression was assayed using immunohistochemistry. Combinative semiquantitative scoring was used for the evaluation of TAM receptor expression (MerTK and AxlTK). Appropriate statistical methods were used to evaluate a possible correlation between TAM receptor expression and the clinicopathological variables of the MM samples (univariate analysis and multivariate analysis). Results: MerTK and AxlTK were expressed differently in the MM samples, with a major expression of the first receptor. The cells of the tumor microenvironment contributed to the majority of the total score. A significant association was found between AxlScore and the site of the tumor and between AxlScore and the variable ulceration; another correlation was found between MerScore and the following characteristics: pathological stage of the tumor (pT), sex, ulceration, and tumor-infiltrating lymphocytes. Conclusions: All correlations between the expression of MerTK and AxlTK with the clinical and histological variables of MM should be validated in a large group of people in order to increase the validity and the impact of our observations, with subsequently therapeutic implications in the era of the “targeted therapy.”
format	article
author	Andrea Pontara Giovanni Paolino Vanesa Gregorc Santo Raffaele Mercuri Alessandra Bulotta Pietro Bearzi Claudio Doglioni Nathalie Rizzo
author_facet	Andrea Pontara Giovanni Paolino Vanesa Gregorc Santo Raffaele Mercuri Alessandra Bulotta Pietro Bearzi Claudio Doglioni Nathalie Rizzo
author_sort	Andrea Pontara
title	Immunohistochemical Evaluation and Clinicopathological Correlation of Mer and Axl Tyrosine Kinase TAM Receptors in Cutaneous Melanoma
title_short	Immunohistochemical Evaluation and Clinicopathological Correlation of Mer and Axl Tyrosine Kinase TAM Receptors in Cutaneous Melanoma
title_full	Immunohistochemical Evaluation and Clinicopathological Correlation of Mer and Axl Tyrosine Kinase TAM Receptors in Cutaneous Melanoma
title_fullStr	Immunohistochemical Evaluation and Clinicopathological Correlation of Mer and Axl Tyrosine Kinase TAM Receptors in Cutaneous Melanoma
title_full_unstemmed	Immunohistochemical Evaluation and Clinicopathological Correlation of Mer and Axl Tyrosine Kinase TAM Receptors in Cutaneous Melanoma
title_sort	immunohistochemical evaluation and clinicopathological correlation of mer and axl tyrosine kinase tam receptors in cutaneous melanoma
publisher	Mattioli1885
publishDate	2020
url	https://doaj.org/article/1befc1b484724b5b89c45d67773b3db1
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Immunohistochemical Evaluation and Clinicopathological Correlation of Mer and Axl Tyrosine Kinase TAM Receptors in Cutaneous Melanoma

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