Programmed death one homolog maintains the pool size of regulatory T cells by promoting their differentiation and stability

Programmed death one homolog maintains the pool size of regulatory T cells by promoting their differentiation and stability

Abstract Programmed death one homolog (PD-1H) is an immunoglobulin superfamily molecule and primarily acts as a coinhibitor in the initiation of T cell response to antigens. Here, we report that genetic ablation of PD-1H in mice blocks the differentiation of naive T cells to Foxp3+ inducible Treg ce...

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Autores principales: Qi Wang, Jianwei He, Dallas B. Flies, Liqun Luo, Lieping Chen
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/1bf05031662a44279ebcf81319210322
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