Alpha-Synuclein, cyclooxygenase-2 and prostaglandins-EP2 receptors as neuroinflammatory biomarkers of autism spectrum disorders: Use of combined ROC curves to increase their diagnostic values

Abstract Background Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by impairments in social interaction and restricted and repetitive behaviors. Neuroinflammation and abnormal lipid mediators have been identified in multiple investigations as an acknowledged etiologica...

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Autores principales:	Afaf El-Ansary, Manan Alhakbany, Abeer Aldbass, Hanan Qasem, Sarah Al-Mazidi, Ramesa Shafi Bhat, Laila Al-Ayadhi
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Autism Neuroinflammation α-Synuclein Cyclooxygenase-2 Prostaglandin-EP2 receptors Nutritional diseases. Deficiency diseases RC620-627
Acceso en línea:	https://doaj.org/article/1bf122d1433c41d5903696c776b86b1c
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spelling	oai:doaj.org-article:1bf122d1433c41d5903696c776b86b1c2021-11-08T11:16:05ZAlpha-Synuclein, cyclooxygenase-2 and prostaglandins-EP2 receptors as neuroinflammatory biomarkers of autism spectrum disorders: Use of combined ROC curves to increase their diagnostic values10.1186/s12944-021-01578-71476-511Xhttps://doaj.org/article/1bf122d1433c41d5903696c776b86b1c2021-11-01T00:00:00Zhttps://doi.org/10.1186/s12944-021-01578-7https://doaj.org/toc/1476-511XAbstract Background Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by impairments in social interaction and restricted and repetitive behaviors. Neuroinflammation and abnormal lipid mediators have been identified in multiple investigations as an acknowledged etiological mechanism of ASD that can be targeted for therapeutic intervention. Methods In this study, multiple regression and combined receiver operating characteristic (ROC) curve analyses were used to determine the relationship between the neuroinflammatory marker α-synuclein and lipid mediator markers related to inflammation induction, such as cyclooxygenase-2 and prostaglandin-EP2 receptors, in the etiology of ASD. Additionally, the study aimed to determine the linear combination that maximizes the partial area under ROC curves for a set of markers. Forty children with ASD and 40 age- and sex-matched controls were enrolled in the study. Using ELISA, the levels of α-synuclein, cyclo-oxygenase-2, and prostaglandin-EP2 receptors were measured in the plasma of both groups. Statistical analyses using ROC curves and multiple and logistic regression models were performed. Results A remarkable increase in the area under the curve was observed using combined ROC curve analyses. Moreover, higher specificity and sensitivity of the combined markers were reported. Conclusions The present study indicates that measurement of the predictive value of selected biomarkers related to neuroinflammation and lipid metabolism in children with ASD using a ROC curve analysis should lead to a better understanding of the etiological mechanism of ASD and its link with metabolism. This information may facilitate early diagnosis and intervention.Afaf El-AnsaryManan AlhakbanyAbeer AldbassHanan QasemSarah Al-MazidiRamesa Shafi BhatLaila Al-AyadhiBMCarticleAutismNeuroinflammationα-SynucleinCyclooxygenase-2Prostaglandin-EP2 receptorsNutritional diseases. Deficiency diseasesRC620-627ENLipids in Health and Disease, Vol 20, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Autism Neuroinflammation α-Synuclein Cyclooxygenase-2 Prostaglandin-EP2 receptors Nutritional diseases. Deficiency diseases RC620-627
spellingShingle	Autism Neuroinflammation α-Synuclein Cyclooxygenase-2 Prostaglandin-EP2 receptors Nutritional diseases. Deficiency diseases RC620-627 Afaf El-Ansary Manan Alhakbany Abeer Aldbass Hanan Qasem Sarah Al-Mazidi Ramesa Shafi Bhat Laila Al-Ayadhi Alpha-Synuclein, cyclooxygenase-2 and prostaglandins-EP2 receptors as neuroinflammatory biomarkers of autism spectrum disorders: Use of combined ROC curves to increase their diagnostic values
description	Abstract Background Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by impairments in social interaction and restricted and repetitive behaviors. Neuroinflammation and abnormal lipid mediators have been identified in multiple investigations as an acknowledged etiological mechanism of ASD that can be targeted for therapeutic intervention. Methods In this study, multiple regression and combined receiver operating characteristic (ROC) curve analyses were used to determine the relationship between the neuroinflammatory marker α-synuclein and lipid mediator markers related to inflammation induction, such as cyclooxygenase-2 and prostaglandin-EP2 receptors, in the etiology of ASD. Additionally, the study aimed to determine the linear combination that maximizes the partial area under ROC curves for a set of markers. Forty children with ASD and 40 age- and sex-matched controls were enrolled in the study. Using ELISA, the levels of α-synuclein, cyclo-oxygenase-2, and prostaglandin-EP2 receptors were measured in the plasma of both groups. Statistical analyses using ROC curves and multiple and logistic regression models were performed. Results A remarkable increase in the area under the curve was observed using combined ROC curve analyses. Moreover, higher specificity and sensitivity of the combined markers were reported. Conclusions The present study indicates that measurement of the predictive value of selected biomarkers related to neuroinflammation and lipid metabolism in children with ASD using a ROC curve analysis should lead to a better understanding of the etiological mechanism of ASD and its link with metabolism. This information may facilitate early diagnosis and intervention.
format	article
author	Afaf El-Ansary Manan Alhakbany Abeer Aldbass Hanan Qasem Sarah Al-Mazidi Ramesa Shafi Bhat Laila Al-Ayadhi
author_facet	Afaf El-Ansary Manan Alhakbany Abeer Aldbass Hanan Qasem Sarah Al-Mazidi Ramesa Shafi Bhat Laila Al-Ayadhi
author_sort	Afaf El-Ansary
title	Alpha-Synuclein, cyclooxygenase-2 and prostaglandins-EP2 receptors as neuroinflammatory biomarkers of autism spectrum disorders: Use of combined ROC curves to increase their diagnostic values
title_short	Alpha-Synuclein, cyclooxygenase-2 and prostaglandins-EP2 receptors as neuroinflammatory biomarkers of autism spectrum disorders: Use of combined ROC curves to increase their diagnostic values
title_full	Alpha-Synuclein, cyclooxygenase-2 and prostaglandins-EP2 receptors as neuroinflammatory biomarkers of autism spectrum disorders: Use of combined ROC curves to increase their diagnostic values
title_fullStr	Alpha-Synuclein, cyclooxygenase-2 and prostaglandins-EP2 receptors as neuroinflammatory biomarkers of autism spectrum disorders: Use of combined ROC curves to increase their diagnostic values
title_full_unstemmed	Alpha-Synuclein, cyclooxygenase-2 and prostaglandins-EP2 receptors as neuroinflammatory biomarkers of autism spectrum disorders: Use of combined ROC curves to increase their diagnostic values
title_sort	alpha-synuclein, cyclooxygenase-2 and prostaglandins-ep2 receptors as neuroinflammatory biomarkers of autism spectrum disorders: use of combined roc curves to increase their diagnostic values
publisher	BMC
publishDate	2021
url	https://doaj.org/article/1bf122d1433c41d5903696c776b86b1c
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Alpha-Synuclein, cyclooxygenase-2 and prostaglandins-EP2 receptors as neuroinflammatory biomarkers of autism spectrum disorders: Use of combined ROC curves to increase their diagnostic values

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