Scalp Biophysical Characteristics in Males with Androgenetic Alopecia: A Comparative Study with Healthy Controls

Kumutnart Chanprapaph, Thanapon Sutharaphan, Poonkiat Suchonwanit Division of Dermatology, Department of Medicine, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, ThailandCorrespondence: Poonkiat SuchonwanitDivision of Dermatology, Department of Medicine, Faculty of Medicine,...

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Autores principales:	Chanprapaph K, Sutharaphan T, Suchonwanit P
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	alopecia hair loss hydration sebum transepidermal water loss Geriatrics RC952-954.6
Acceso en línea:	https://doaj.org/article/1bf214d8c7fa4cde931e33318468f05f
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spelling	oai:doaj.org-article:1bf214d8c7fa4cde931e33318468f05f2021-12-02T15:36:37ZScalp Biophysical Characteristics in Males with Androgenetic Alopecia: A Comparative Study with Healthy Controls1178-1998https://doaj.org/article/1bf214d8c7fa4cde931e33318468f05f2021-05-01T00:00:00Zhttps://www.dovepress.com/scalp-biophysical-characteristics-in-males-with-androgenetic-alopecia--peer-reviewed-fulltext-article-CIAhttps://doaj.org/toc/1178-1998Kumutnart Chanprapaph, Thanapon Sutharaphan, Poonkiat Suchonwanit Division of Dermatology, Department of Medicine, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, ThailandCorrespondence: Poonkiat SuchonwanitDivision of Dermatology, Department of Medicine, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, 270 Rama VI Road, Ratchathewi, Bangkok, 10400, ThailandTel +66-2-2011141Fax +66-2-201-1211 ext 4Email poonkiat@hotmail.comBackground: Androgenetic alopecia (AGA) is the most common type of hair loss in men. Its prevalence increases with advancing age. Characteristics of hair loss in male AGA reveal the possibility of different biophysical and physiological profiles between androgen-sensitive (vertex) and androgen-insensitive (occipital) scalps. However, these variations have not been well investigated.Objective: We aimed to evaluate and compare scalp biophysical and physiological characteristics in male AGA patients and healthy controls.Methods: Scalp biophysiological profiles were evaluated by non-invasive measuring techniques, including skin surface lipids (SSL), transepidermal water loss (TEWL), and stratum corneum hydration (SCH) on both vertex and occipital areas. Values were compared between scalp areas and study groups. Participants with AGA were further categorized based on disease severity (Hamilton–Norwood classification) for subgroup analyses. Correlation coefficients were evaluated to determine the effects of AGA severity and age on each functional parameter.Results: Participants were 31 AGA subjects and 31 healthy controls. The vertex scalp of AGA patients had significantly higher SSL (p = 0.03) and lower SCH (p = 0.02) compared to the occipital scalp. TEWL was not significantly different (p = 0.31). AGA group SSL showed a positive correlation with severity of hair loss (r = 0.61, p = 0.03). When compared to controls, the AGA group vertex scalp had significantly higher SSL (p = 0.03) and lower TEWL (p < 0.001). The occipital area showed no statistically significant differences.Conclusion: Male AGA presents with different biophysical and physiological characteristics in androgen-sensitive and androgen-insensitive areas, and with further differences from controls. These findings could direct further research and aid in the development of optimal hair and scalp treatments to improve scalp functional profiles in particular patients.Keywords: alopecia, hair loss, hydration, sebum, transepidermal water lossChanprapaph KSutharaphan TSuchonwanit PDove Medical Pressarticlealopeciahair losshydrationsebumtransepidermal water lossGeriatricsRC952-954.6ENClinical Interventions in Aging, Vol Volume 16, Pp 781-787 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	alopecia hair loss hydration sebum transepidermal water loss Geriatrics RC952-954.6
spellingShingle	alopecia hair loss hydration sebum transepidermal water loss Geriatrics RC952-954.6 Chanprapaph K Sutharaphan T Suchonwanit P Scalp Biophysical Characteristics in Males with Androgenetic Alopecia: A Comparative Study with Healthy Controls
description	Kumutnart Chanprapaph, Thanapon Sutharaphan, Poonkiat Suchonwanit Division of Dermatology, Department of Medicine, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, ThailandCorrespondence: Poonkiat SuchonwanitDivision of Dermatology, Department of Medicine, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, 270 Rama VI Road, Ratchathewi, Bangkok, 10400, ThailandTel +66-2-2011141Fax +66-2-201-1211 ext 4Email poonkiat@hotmail.comBackground: Androgenetic alopecia (AGA) is the most common type of hair loss in men. Its prevalence increases with advancing age. Characteristics of hair loss in male AGA reveal the possibility of different biophysical and physiological profiles between androgen-sensitive (vertex) and androgen-insensitive (occipital) scalps. However, these variations have not been well investigated.Objective: We aimed to evaluate and compare scalp biophysical and physiological characteristics in male AGA patients and healthy controls.Methods: Scalp biophysiological profiles were evaluated by non-invasive measuring techniques, including skin surface lipids (SSL), transepidermal water loss (TEWL), and stratum corneum hydration (SCH) on both vertex and occipital areas. Values were compared between scalp areas and study groups. Participants with AGA were further categorized based on disease severity (Hamilton–Norwood classification) for subgroup analyses. Correlation coefficients were evaluated to determine the effects of AGA severity and age on each functional parameter.Results: Participants were 31 AGA subjects and 31 healthy controls. The vertex scalp of AGA patients had significantly higher SSL (p = 0.03) and lower SCH (p = 0.02) compared to the occipital scalp. TEWL was not significantly different (p = 0.31). AGA group SSL showed a positive correlation with severity of hair loss (r = 0.61, p = 0.03). When compared to controls, the AGA group vertex scalp had significantly higher SSL (p = 0.03) and lower TEWL (p < 0.001). The occipital area showed no statistically significant differences.Conclusion: Male AGA presents with different biophysical and physiological characteristics in androgen-sensitive and androgen-insensitive areas, and with further differences from controls. These findings could direct further research and aid in the development of optimal hair and scalp treatments to improve scalp functional profiles in particular patients.Keywords: alopecia, hair loss, hydration, sebum, transepidermal water loss
format	article
author	Chanprapaph K Sutharaphan T Suchonwanit P
author_facet	Chanprapaph K Sutharaphan T Suchonwanit P
author_sort	Chanprapaph K
title	Scalp Biophysical Characteristics in Males with Androgenetic Alopecia: A Comparative Study with Healthy Controls
title_short	Scalp Biophysical Characteristics in Males with Androgenetic Alopecia: A Comparative Study with Healthy Controls
title_full	Scalp Biophysical Characteristics in Males with Androgenetic Alopecia: A Comparative Study with Healthy Controls
title_fullStr	Scalp Biophysical Characteristics in Males with Androgenetic Alopecia: A Comparative Study with Healthy Controls
title_full_unstemmed	Scalp Biophysical Characteristics in Males with Androgenetic Alopecia: A Comparative Study with Healthy Controls
title_sort	scalp biophysical characteristics in males with androgenetic alopecia: a comparative study with healthy controls
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/1bf214d8c7fa4cde931e33318468f05f
work_keys_str_mv	AT chanprapaphk scalpbiophysicalcharacteristicsinmaleswithandrogeneticalopeciaacomparativestudywithhealthycontrols AT sutharaphant scalpbiophysicalcharacteristicsinmaleswithandrogeneticalopeciaacomparativestudywithhealthycontrols AT suchonwanitp scalpbiophysicalcharacteristicsinmaleswithandrogeneticalopeciaacomparativestudywithhealthycontrols
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Scalp Biophysical Characteristics in Males with Androgenetic Alopecia: A Comparative Study with Healthy Controls

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