Improving the safety of human pluripotent stem cell therapies using genome-edited orthogonal safeguards

Human pluripotent stem cell derived therapies can have serious safety risks. Here the authors design two drug inducible genetic safeguards to deplete undifferentiated hPSCs and hPSC-derived cell types.

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Autores principales:	Renata M. Martin, Jonas L. Fowler, M. Kyle Cromer, Benjamin J. Lesch, Ezequiel Ponce, Nobuko Uchida, Toshinobu Nishimura, Matthew H. Porteus, Kyle M. Loh
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/1bf355be0de745bc987455ce3536745a
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spelling	oai:doaj.org-article:1bf355be0de745bc987455ce3536745a2021-12-02T15:02:47ZImproving the safety of human pluripotent stem cell therapies using genome-edited orthogonal safeguards10.1038/s41467-020-16455-72041-1723https://doaj.org/article/1bf355be0de745bc987455ce3536745a2020-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16455-7https://doaj.org/toc/2041-1723Human pluripotent stem cell derived therapies can have serious safety risks. Here the authors design two drug inducible genetic safeguards to deplete undifferentiated hPSCs and hPSC-derived cell types.Renata M. MartinJonas L. FowlerM. Kyle CromerBenjamin J. LeschEzequiel PonceNobuko UchidaToshinobu NishimuraMatthew H. PorteusKyle M. LohNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Renata M. Martin Jonas L. Fowler M. Kyle Cromer Benjamin J. Lesch Ezequiel Ponce Nobuko Uchida Toshinobu Nishimura Matthew H. Porteus Kyle M. Loh Improving the safety of human pluripotent stem cell therapies using genome-edited orthogonal safeguards
description	Human pluripotent stem cell derived therapies can have serious safety risks. Here the authors design two drug inducible genetic safeguards to deplete undifferentiated hPSCs and hPSC-derived cell types.
format	article
author	Renata M. Martin Jonas L. Fowler M. Kyle Cromer Benjamin J. Lesch Ezequiel Ponce Nobuko Uchida Toshinobu Nishimura Matthew H. Porteus Kyle M. Loh
author_facet	Renata M. Martin Jonas L. Fowler M. Kyle Cromer Benjamin J. Lesch Ezequiel Ponce Nobuko Uchida Toshinobu Nishimura Matthew H. Porteus Kyle M. Loh
author_sort	Renata M. Martin
title	Improving the safety of human pluripotent stem cell therapies using genome-edited orthogonal safeguards
title_short	Improving the safety of human pluripotent stem cell therapies using genome-edited orthogonal safeguards
title_full	Improving the safety of human pluripotent stem cell therapies using genome-edited orthogonal safeguards
title_fullStr	Improving the safety of human pluripotent stem cell therapies using genome-edited orthogonal safeguards
title_full_unstemmed	Improving the safety of human pluripotent stem cell therapies using genome-edited orthogonal safeguards
title_sort	improving the safety of human pluripotent stem cell therapies using genome-edited orthogonal safeguards
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/1bf355be0de745bc987455ce3536745a
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Improving the safety of human pluripotent stem cell therapies using genome-edited orthogonal safeguards

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