Improving the safety of human pluripotent stem cell therapies using genome-edited orthogonal safeguards

Improving the safety of human pluripotent stem cell therapies using genome-edited orthogonal safeguards

Human pluripotent stem cell derived therapies can have serious safety risks. Here the authors design two drug inducible genetic safeguards to deplete undifferentiated hPSCs and hPSC-derived cell types.

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Detalles Bibliográficos
Autores principales: Renata M. Martin, Jonas L. Fowler, M. Kyle Cromer, Benjamin J. Lesch, Ezequiel Ponce, Nobuko Uchida, Toshinobu Nishimura, Matthew H. Porteus, Kyle M. Loh
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
Materias:
Science
Q
Acceso en línea:https://doaj.org/article/1bf355be0de745bc987455ce3536745a
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