Birth weight, working memory and epigenetic signatures in IGF2 and related genes: a MZ twin study.

Neurodevelopmental disruptions caused by obstetric complications play a role in the etiology of several phenotypes associated with neuropsychiatric diseases and cognitive dysfunctions. Importantly, it has been noticed that epigenetic processes occurring early in life may mediate these associations....

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Autores principales:	Aldo Córdova-Palomera, Silvia Alemany, Mar Fatjó-Vilas, Ximena Goldberg, Juan Carlos Leza, Ana González-Pinto, Igor Nenadic, Lourdes Fañanás
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/1bf47fbbc9d04dadbd1267107fa0598d
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spelling	oai:doaj.org-article:1bf47fbbc9d04dadbd1267107fa0598d2021-11-25T06:02:42ZBirth weight, working memory and epigenetic signatures in IGF2 and related genes: a MZ twin study.1932-620310.1371/journal.pone.0103639https://doaj.org/article/1bf47fbbc9d04dadbd1267107fa0598d2014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/25171170/?tool=EBIhttps://doaj.org/toc/1932-6203Neurodevelopmental disruptions caused by obstetric complications play a role in the etiology of several phenotypes associated with neuropsychiatric diseases and cognitive dysfunctions. Importantly, it has been noticed that epigenetic processes occurring early in life may mediate these associations. Here, DNA methylation signatures at IGF2 (insulin-like growth factor 2) and IGF2BP1-3 (IGF2-binding proteins 1-3) were examined in a sample consisting of 34 adult monozygotic (MZ) twins informative for obstetric complications and cognitive performance. Multivariate linear regression analysis of twin data was implemented to test for associations between methylation levels and both birth weight (BW) and adult working memory (WM) performance. Familial and unique environmental factors underlying these potential relationships were evaluated. A link was detected between DNA methylation levels of two CpG sites in the IGF2BP1 gene and both BW and adult WM performance. The BW-IGF2BP1 methylation association seemed due to non-shared environmental factors influencing BW, whereas the WM-IGF2BP1 methylation relationship seemed mediated by both genes and environment. Our data is in agreement with previous evidence indicating that DNA methylation status may be related to prenatal stress and later neurocognitive phenotypes. While former reports independently detected associations between DNA methylation and either BW or WM, current results suggest that these relationships are not confounded by each other.Aldo Córdova-PalomeraSilvia AlemanyMar Fatjó-VilasXimena GoldbergJuan Carlos LezaAna González-PintoIgor NenadicLourdes FañanásPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 8, p e103639 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Aldo Córdova-Palomera Silvia Alemany Mar Fatjó-Vilas Ximena Goldberg Juan Carlos Leza Ana González-Pinto Igor Nenadic Lourdes Fañanás Birth weight, working memory and epigenetic signatures in IGF2 and related genes: a MZ twin study.
description	Neurodevelopmental disruptions caused by obstetric complications play a role in the etiology of several phenotypes associated with neuropsychiatric diseases and cognitive dysfunctions. Importantly, it has been noticed that epigenetic processes occurring early in life may mediate these associations. Here, DNA methylation signatures at IGF2 (insulin-like growth factor 2) and IGF2BP1-3 (IGF2-binding proteins 1-3) were examined in a sample consisting of 34 adult monozygotic (MZ) twins informative for obstetric complications and cognitive performance. Multivariate linear regression analysis of twin data was implemented to test for associations between methylation levels and both birth weight (BW) and adult working memory (WM) performance. Familial and unique environmental factors underlying these potential relationships were evaluated. A link was detected between DNA methylation levels of two CpG sites in the IGF2BP1 gene and both BW and adult WM performance. The BW-IGF2BP1 methylation association seemed due to non-shared environmental factors influencing BW, whereas the WM-IGF2BP1 methylation relationship seemed mediated by both genes and environment. Our data is in agreement with previous evidence indicating that DNA methylation status may be related to prenatal stress and later neurocognitive phenotypes. While former reports independently detected associations between DNA methylation and either BW or WM, current results suggest that these relationships are not confounded by each other.
format	article
author	Aldo Córdova-Palomera Silvia Alemany Mar Fatjó-Vilas Ximena Goldberg Juan Carlos Leza Ana González-Pinto Igor Nenadic Lourdes Fañanás
author_facet	Aldo Córdova-Palomera Silvia Alemany Mar Fatjó-Vilas Ximena Goldberg Juan Carlos Leza Ana González-Pinto Igor Nenadic Lourdes Fañanás
author_sort	Aldo Córdova-Palomera
title	Birth weight, working memory and epigenetic signatures in IGF2 and related genes: a MZ twin study.
title_short	Birth weight, working memory and epigenetic signatures in IGF2 and related genes: a MZ twin study.
title_full	Birth weight, working memory and epigenetic signatures in IGF2 and related genes: a MZ twin study.
title_fullStr	Birth weight, working memory and epigenetic signatures in IGF2 and related genes: a MZ twin study.
title_full_unstemmed	Birth weight, working memory and epigenetic signatures in IGF2 and related genes: a MZ twin study.
title_sort	birth weight, working memory and epigenetic signatures in igf2 and related genes: a mz twin study.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/1bf47fbbc9d04dadbd1267107fa0598d
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Birth weight, working memory and epigenetic signatures in IGF2 and related genes: a MZ twin study.

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