Directed-evolution of translation system for efficient unnatural amino acids incorporation and generalizable synthetic auxotroph construction

Directed-evolution of translation system for efficient unnatural amino acids incorporation and generalizable synthetic auxotroph construction

In this paper, the authors report the directed-evolution of translation systems that allow the incorporation of unnatural amino acids with similar efficiency to natural amino acids and the construction of synthetic auxotroph in a generalizable way.

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Autores principales: Hongxia Zhao, Wenlong Ding, Jia Zang, Yang Yang, Chao Liu, Linzhen Hu, Yulin Chen, Guanglong Liu, Yu Fang, Ying Yuan, Shixian Lin
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/1bf4b6f580834b37bd653778889991d8
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spelling oai:doaj.org-article:1bf4b6f580834b37bd653778889991d82021-12-05T12:22:51ZDirected-evolution of translation system for efficient unnatural amino acids incorporation and generalizable synthetic auxotroph construction10.1038/s41467-021-27399-x2041-1723https://doaj.org/article/1bf4b6f580834b37bd653778889991d82021-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-27399-xhttps://doaj.org/toc/2041-1723In this paper, the authors report the directed-evolution of translation systems that allow the incorporation of unnatural amino acids with similar efficiency to natural amino acids and the construction of synthetic auxotroph in a generalizable way.Hongxia ZhaoWenlong DingJia ZangYang YangChao LiuLinzhen HuYulin ChenGuanglong LiuYu FangYing YuanShixian LinNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Hongxia Zhao
Wenlong Ding
Jia Zang
Yang Yang
Chao Liu
Linzhen Hu
Yulin Chen
Guanglong Liu
Yu Fang
Ying Yuan
Shixian Lin
Directed-evolution of translation system for efficient unnatural amino acids incorporation and generalizable synthetic auxotroph construction
description In this paper, the authors report the directed-evolution of translation systems that allow the incorporation of unnatural amino acids with similar efficiency to natural amino acids and the construction of synthetic auxotroph in a generalizable way.
format article
author Hongxia Zhao
Wenlong Ding
Jia Zang
Yang Yang
Chao Liu
Linzhen Hu
Yulin Chen
Guanglong Liu
Yu Fang
Ying Yuan
Shixian Lin
author_facet Hongxia Zhao
Wenlong Ding
Jia Zang
Yang Yang
Chao Liu
Linzhen Hu
Yulin Chen
Guanglong Liu
Yu Fang
Ying Yuan
Shixian Lin
author_sort Hongxia Zhao
title Directed-evolution of translation system for efficient unnatural amino acids incorporation and generalizable synthetic auxotroph construction
title_short Directed-evolution of translation system for efficient unnatural amino acids incorporation and generalizable synthetic auxotroph construction
title_full Directed-evolution of translation system for efficient unnatural amino acids incorporation and generalizable synthetic auxotroph construction
title_fullStr Directed-evolution of translation system for efficient unnatural amino acids incorporation and generalizable synthetic auxotroph construction
title_full_unstemmed Directed-evolution of translation system for efficient unnatural amino acids incorporation and generalizable synthetic auxotroph construction
title_sort directed-evolution of translation system for efficient unnatural amino acids incorporation and generalizable synthetic auxotroph construction
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/1bf4b6f580834b37bd653778889991d8
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AT yingyuan directedevolutionoftranslationsystemforefficientunnaturalaminoacidsincorporationandgeneralizablesyntheticauxotrophconstruction
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