Nanodiamond autophagy inhibitor allosterically improves the arsenical-based therapy of solid tumors

Arsenic trioxide (ATO) based therapy in solid cancers is limited. Here they repurpose nanodiamonds (NDs) as a safe and potent autophagic inhibitor to improve the efficacy of ATO-based treatment in solid tumors and show the combination therapy to work better in orthotopic liver cancer model.

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Autores principales: Zhifen Cui, Yu Zhang, Kai Xia, Qinglong Yan, Huating Kong, Jichao Zhang, Xiaolei Zuo, Jiye Shi, Lihua Wang, Ying Zhu, Chunhai Fan
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/1bf72d2d168c489c90f7ceab014ac31a
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spelling oai:doaj.org-article:1bf72d2d168c489c90f7ceab014ac31a2021-12-02T14:39:10ZNanodiamond autophagy inhibitor allosterically improves the arsenical-based therapy of solid tumors10.1038/s41467-018-06749-22041-1723https://doaj.org/article/1bf72d2d168c489c90f7ceab014ac31a2018-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06749-2https://doaj.org/toc/2041-1723Arsenic trioxide (ATO) based therapy in solid cancers is limited. Here they repurpose nanodiamonds (NDs) as a safe and potent autophagic inhibitor to improve the efficacy of ATO-based treatment in solid tumors and show the combination therapy to work better in orthotopic liver cancer model.Zhifen CuiYu ZhangKai XiaQinglong YanHuating KongJichao ZhangXiaolei ZuoJiye ShiLihua WangYing ZhuChunhai FanNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Zhifen Cui
Yu Zhang
Kai Xia
Qinglong Yan
Huating Kong
Jichao Zhang
Xiaolei Zuo
Jiye Shi
Lihua Wang
Ying Zhu
Chunhai Fan
Nanodiamond autophagy inhibitor allosterically improves the arsenical-based therapy of solid tumors
description Arsenic trioxide (ATO) based therapy in solid cancers is limited. Here they repurpose nanodiamonds (NDs) as a safe and potent autophagic inhibitor to improve the efficacy of ATO-based treatment in solid tumors and show the combination therapy to work better in orthotopic liver cancer model.
format article
author Zhifen Cui
Yu Zhang
Kai Xia
Qinglong Yan
Huating Kong
Jichao Zhang
Xiaolei Zuo
Jiye Shi
Lihua Wang
Ying Zhu
Chunhai Fan
author_facet Zhifen Cui
Yu Zhang
Kai Xia
Qinglong Yan
Huating Kong
Jichao Zhang
Xiaolei Zuo
Jiye Shi
Lihua Wang
Ying Zhu
Chunhai Fan
author_sort Zhifen Cui
title Nanodiamond autophagy inhibitor allosterically improves the arsenical-based therapy of solid tumors
title_short Nanodiamond autophagy inhibitor allosterically improves the arsenical-based therapy of solid tumors
title_full Nanodiamond autophagy inhibitor allosterically improves the arsenical-based therapy of solid tumors
title_fullStr Nanodiamond autophagy inhibitor allosterically improves the arsenical-based therapy of solid tumors
title_full_unstemmed Nanodiamond autophagy inhibitor allosterically improves the arsenical-based therapy of solid tumors
title_sort nanodiamond autophagy inhibitor allosterically improves the arsenical-based therapy of solid tumors
publisher Nature Portfolio
publishDate 2018
url https://doaj.org/article/1bf72d2d168c489c90f7ceab014ac31a
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