Nanodiamond autophagy inhibitor allosterically improves the arsenical-based therapy of solid tumors
Arsenic trioxide (ATO) based therapy in solid cancers is limited. Here they repurpose nanodiamonds (NDs) as a safe and potent autophagic inhibitor to improve the efficacy of ATO-based treatment in solid tumors and show the combination therapy to work better in orthotopic liver cancer model.
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Nature Portfolio
2018
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oai:doaj.org-article:1bf72d2d168c489c90f7ceab014ac31a2021-12-02T14:39:10ZNanodiamond autophagy inhibitor allosterically improves the arsenical-based therapy of solid tumors10.1038/s41467-018-06749-22041-1723https://doaj.org/article/1bf72d2d168c489c90f7ceab014ac31a2018-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06749-2https://doaj.org/toc/2041-1723Arsenic trioxide (ATO) based therapy in solid cancers is limited. Here they repurpose nanodiamonds (NDs) as a safe and potent autophagic inhibitor to improve the efficacy of ATO-based treatment in solid tumors and show the combination therapy to work better in orthotopic liver cancer model.Zhifen CuiYu ZhangKai XiaQinglong YanHuating KongJichao ZhangXiaolei ZuoJiye ShiLihua WangYing ZhuChunhai FanNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-11 (2018) |
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Science Q Zhifen Cui Yu Zhang Kai Xia Qinglong Yan Huating Kong Jichao Zhang Xiaolei Zuo Jiye Shi Lihua Wang Ying Zhu Chunhai Fan Nanodiamond autophagy inhibitor allosterically improves the arsenical-based therapy of solid tumors |
description |
Arsenic trioxide (ATO) based therapy in solid cancers is limited. Here they repurpose nanodiamonds (NDs) as a safe and potent autophagic inhibitor to improve the efficacy of ATO-based treatment in solid tumors and show the combination therapy to work better in orthotopic liver cancer model. |
format |
article |
author |
Zhifen Cui Yu Zhang Kai Xia Qinglong Yan Huating Kong Jichao Zhang Xiaolei Zuo Jiye Shi Lihua Wang Ying Zhu Chunhai Fan |
author_facet |
Zhifen Cui Yu Zhang Kai Xia Qinglong Yan Huating Kong Jichao Zhang Xiaolei Zuo Jiye Shi Lihua Wang Ying Zhu Chunhai Fan |
author_sort |
Zhifen Cui |
title |
Nanodiamond autophagy inhibitor allosterically improves the arsenical-based therapy of solid tumors |
title_short |
Nanodiamond autophagy inhibitor allosterically improves the arsenical-based therapy of solid tumors |
title_full |
Nanodiamond autophagy inhibitor allosterically improves the arsenical-based therapy of solid tumors |
title_fullStr |
Nanodiamond autophagy inhibitor allosterically improves the arsenical-based therapy of solid tumors |
title_full_unstemmed |
Nanodiamond autophagy inhibitor allosterically improves the arsenical-based therapy of solid tumors |
title_sort |
nanodiamond autophagy inhibitor allosterically improves the arsenical-based therapy of solid tumors |
publisher |
Nature Portfolio |
publishDate |
2018 |
url |
https://doaj.org/article/1bf72d2d168c489c90f7ceab014ac31a |
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