The effect of Swedish snuff (snus) on offspring birthweight: a sibling analysis.

Current observational evidence indicates that maternal smoking during pregnancy is associated with reduced birthweight in offspring. However, less is known about the effect of smokeless tobacco on birthweight and about the possible mechanisms involved in this relationship. This paper studies the eff...

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Autores principales:	Sol Pía Juárez, Juan Merlo
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/1bfdfcfc61be439baaffce2476c133a1
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spelling	oai:doaj.org-article:1bfdfcfc61be439baaffce2476c133a12021-11-18T07:42:07ZThe effect of Swedish snuff (snus) on offspring birthweight: a sibling analysis.1932-620310.1371/journal.pone.0065611https://doaj.org/article/1bfdfcfc61be439baaffce2476c133a12013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23776512/?tool=EBIhttps://doaj.org/toc/1932-6203Current observational evidence indicates that maternal smoking during pregnancy is associated with reduced birthweight in offspring. However, less is known about the effect of smokeless tobacco on birthweight and about the possible mechanisms involved in this relationship. This paper studies the effect of Swedish smokeless tobacco (snus) on offspring birthweight comparing the results obtained from a conventional linear regression analysis and from a quasi-experimental sibling design using a multilevel linear regression analysis. From the Swedish Medical Birth Register, we investigated 604,804 singletons born between 2002 and 2010. From them, we isolated 8,861 siblings from 4,104 mothers with discrepant snus-use habits (i.e., women who had at least one pregnancy during which they used snus and at least one other pregnancy in which they did not). The conventional analysis shows that continuous snus use throughout the pregnancy reduces birthweight in 47 g while quitting or relapsing snus has a minor and statistically non-significant effect (-6 g and -4 g, respectively). However, using a sibling analysis the effect observed for mothers who continue to use snus during pregnancy is less intense than that observed with previous conventional analyses (-20 g), and this effect is not statistically significant. Sibling analysis shows that quitting or relapsing snus use after the first trimester slightly reduces birthweight (14 g). However, this small change is not statistically significant. The sibling analysis provides strong causal evidence indicating that exposure to snus during pregnancy has a minor effect on birthweight reduction. Our findings provide a new piece of causal evidence concerning the effect of tobacco on birthweight and support the hypothesis that the harmful effect of smoking on birthweight is not mainly due to nicotine.Sol Pía JuárezJuan MerloPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 6, p e65611 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Sol Pía Juárez Juan Merlo The effect of Swedish snuff (snus) on offspring birthweight: a sibling analysis.
description	Current observational evidence indicates that maternal smoking during pregnancy is associated with reduced birthweight in offspring. However, less is known about the effect of smokeless tobacco on birthweight and about the possible mechanisms involved in this relationship. This paper studies the effect of Swedish smokeless tobacco (snus) on offspring birthweight comparing the results obtained from a conventional linear regression analysis and from a quasi-experimental sibling design using a multilevel linear regression analysis. From the Swedish Medical Birth Register, we investigated 604,804 singletons born between 2002 and 2010. From them, we isolated 8,861 siblings from 4,104 mothers with discrepant snus-use habits (i.e., women who had at least one pregnancy during which they used snus and at least one other pregnancy in which they did not). The conventional analysis shows that continuous snus use throughout the pregnancy reduces birthweight in 47 g while quitting or relapsing snus has a minor and statistically non-significant effect (-6 g and -4 g, respectively). However, using a sibling analysis the effect observed for mothers who continue to use snus during pregnancy is less intense than that observed with previous conventional analyses (-20 g), and this effect is not statistically significant. Sibling analysis shows that quitting or relapsing snus use after the first trimester slightly reduces birthweight (14 g). However, this small change is not statistically significant. The sibling analysis provides strong causal evidence indicating that exposure to snus during pregnancy has a minor effect on birthweight reduction. Our findings provide a new piece of causal evidence concerning the effect of tobacco on birthweight and support the hypothesis that the harmful effect of smoking on birthweight is not mainly due to nicotine.
format	article
author	Sol Pía Juárez Juan Merlo
author_facet	Sol Pía Juárez Juan Merlo
author_sort	Sol Pía Juárez
title	The effect of Swedish snuff (snus) on offspring birthweight: a sibling analysis.
title_short	The effect of Swedish snuff (snus) on offspring birthweight: a sibling analysis.
title_full	The effect of Swedish snuff (snus) on offspring birthweight: a sibling analysis.
title_fullStr	The effect of Swedish snuff (snus) on offspring birthweight: a sibling analysis.
title_full_unstemmed	The effect of Swedish snuff (snus) on offspring birthweight: a sibling analysis.
title_sort	effect of swedish snuff (snus) on offspring birthweight: a sibling analysis.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/1bfdfcfc61be439baaffce2476c133a1
work_keys_str_mv	AT solpiajuarez theeffectofswedishsnuffsnusonoffspringbirthweightasiblinganalysis AT juanmerlo theeffectofswedishsnuffsnusonoffspringbirthweightasiblinganalysis AT solpiajuarez effectofswedishsnuffsnusonoffspringbirthweightasiblinganalysis AT juanmerlo effectofswedishsnuffsnusonoffspringbirthweightasiblinganalysis
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The effect of Swedish snuff (snus) on offspring birthweight: a sibling analysis.

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