The CXCL5/CXCR2 axis is sufficient to promote breast cancer colonization during bone metastasis

Breast cancer cells often invade the bone tissue and remain dormant until they are induced to colonize the metastatic site. Here the authors develop an ex vivo co-culture system consisting of bone and cancer cells from mice and show that CXCL5 has a role in metastatic colonization in the bone.

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Autores principales:	Ricardo Romero-Moreno, Kimberly J. Curtis, Thomas R. Coughlin, Maria Cristina Miranda-Vergara, Shourik Dutta, Aishwarya Natarajan, Beth A. Facchine, Kristen M. Jackson, Lukas Nystrom, Jun Li, William Kaliney, Glen L. Niebur, Laurie E. Littlepage
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/1bfdfe5013bb48ed8014130e01ca4ba9
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spelling	oai:doaj.org-article:1bfdfe5013bb48ed8014130e01ca4ba92021-12-02T14:39:20ZThe CXCL5/CXCR2 axis is sufficient to promote breast cancer colonization during bone metastasis10.1038/s41467-019-12108-62041-1723https://doaj.org/article/1bfdfe5013bb48ed8014130e01ca4ba92019-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12108-6https://doaj.org/toc/2041-1723Breast cancer cells often invade the bone tissue and remain dormant until they are induced to colonize the metastatic site. Here the authors develop an ex vivo co-culture system consisting of bone and cancer cells from mice and show that CXCL5 has a role in metastatic colonization in the bone.Ricardo Romero-MorenoKimberly J. CurtisThomas R. CoughlinMaria Cristina Miranda-VergaraShourik DuttaAishwarya NatarajanBeth A. FacchineKristen M. JacksonLukas NystromJun LiWilliam KalineyGlen L. NieburLaurie E. LittlepageNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ricardo Romero-Moreno Kimberly J. Curtis Thomas R. Coughlin Maria Cristina Miranda-Vergara Shourik Dutta Aishwarya Natarajan Beth A. Facchine Kristen M. Jackson Lukas Nystrom Jun Li William Kaliney Glen L. Niebur Laurie E. Littlepage The CXCL5/CXCR2 axis is sufficient to promote breast cancer colonization during bone metastasis
description	Breast cancer cells often invade the bone tissue and remain dormant until they are induced to colonize the metastatic site. Here the authors develop an ex vivo co-culture system consisting of bone and cancer cells from mice and show that CXCL5 has a role in metastatic colonization in the bone.
format	article
author	Ricardo Romero-Moreno Kimberly J. Curtis Thomas R. Coughlin Maria Cristina Miranda-Vergara Shourik Dutta Aishwarya Natarajan Beth A. Facchine Kristen M. Jackson Lukas Nystrom Jun Li William Kaliney Glen L. Niebur Laurie E. Littlepage
author_facet	Ricardo Romero-Moreno Kimberly J. Curtis Thomas R. Coughlin Maria Cristina Miranda-Vergara Shourik Dutta Aishwarya Natarajan Beth A. Facchine Kristen M. Jackson Lukas Nystrom Jun Li William Kaliney Glen L. Niebur Laurie E. Littlepage
author_sort	Ricardo Romero-Moreno
title	The CXCL5/CXCR2 axis is sufficient to promote breast cancer colonization during bone metastasis
title_short	The CXCL5/CXCR2 axis is sufficient to promote breast cancer colonization during bone metastasis
title_full	The CXCL5/CXCR2 axis is sufficient to promote breast cancer colonization during bone metastasis
title_fullStr	The CXCL5/CXCR2 axis is sufficient to promote breast cancer colonization during bone metastasis
title_full_unstemmed	The CXCL5/CXCR2 axis is sufficient to promote breast cancer colonization during bone metastasis
title_sort	cxcl5/cxcr2 axis is sufficient to promote breast cancer colonization during bone metastasis
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/1bfdfe5013bb48ed8014130e01ca4ba9
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The CXCL5/CXCR2 axis is sufficient to promote breast cancer colonization during bone metastasis

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