Understanding menstrual blood-derived stromal/stem cells: Definition and properties. Are we rushing into their therapeutic applications?

Summary: Cells with mesenchymal stem cell properties have been identified in menstrual blood and termed menstrual blood-derived stem/stromal cells (MenSCs). MenSCs have been proposed as ideal candidates for cell-based therapy in regenerative medicine and immune-related diseases. However, MenSCs iden...

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Autores principales:	Alicia Sanchez-Mata, Elena Gonzalez-Muñoz
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Reproductive medicine Cell biology Stem cells research Science Q
Acceso en línea:	https://doaj.org/article/1c03d3fe067f4cecba282faa6269e0e6
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spelling	oai:doaj.org-article:1c03d3fe067f4cecba282faa6269e0e62021-12-04T04:35:36ZUnderstanding menstrual blood-derived stromal/stem cells: Definition and properties. Are we rushing into their therapeutic applications?2589-004210.1016/j.isci.2021.103501https://doaj.org/article/1c03d3fe067f4cecba282faa6269e0e62021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2589004221014723https://doaj.org/toc/2589-0042Summary: Cells with mesenchymal stem cell properties have been identified in menstrual blood and termed menstrual blood-derived stem/stromal cells (MenSCs). MenSCs have been proposed as ideal candidates for cell-based therapy in regenerative medicine and immune-related diseases. However, MenSCs identity has been loosely defined so far and there is controversy regarding their cell markers and differentiation potential. In this review, we outline the origin of MenSCs in the context of regenerating human endometrium, with attention to endometrial eMSCs as reference cells to understand MenSCs. We summarize the cell identity markers analyzed and the immunomodulatory and reparative properties reported. We also address the recent use of MenSCs in cell reprogramming. The main goal of this review is to contribute to the understanding of the identity and properties of MenSCs as well as to identify potential caveats and new venues that deserve to be explored to strengthen their potential applications.Alicia Sanchez-MataElena Gonzalez-MuñozElsevierarticleReproductive medicineCell biologyStem cells researchScienceQENiScience, Vol 24, Iss 12, Pp 103501- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Reproductive medicine Cell biology Stem cells research Science Q
spellingShingle	Reproductive medicine Cell biology Stem cells research Science Q Alicia Sanchez-Mata Elena Gonzalez-Muñoz Understanding menstrual blood-derived stromal/stem cells: Definition and properties. Are we rushing into their therapeutic applications?
description	Summary: Cells with mesenchymal stem cell properties have been identified in menstrual blood and termed menstrual blood-derived stem/stromal cells (MenSCs). MenSCs have been proposed as ideal candidates for cell-based therapy in regenerative medicine and immune-related diseases. However, MenSCs identity has been loosely defined so far and there is controversy regarding their cell markers and differentiation potential. In this review, we outline the origin of MenSCs in the context of regenerating human endometrium, with attention to endometrial eMSCs as reference cells to understand MenSCs. We summarize the cell identity markers analyzed and the immunomodulatory and reparative properties reported. We also address the recent use of MenSCs in cell reprogramming. The main goal of this review is to contribute to the understanding of the identity and properties of MenSCs as well as to identify potential caveats and new venues that deserve to be explored to strengthen their potential applications.
format	article
author	Alicia Sanchez-Mata Elena Gonzalez-Muñoz
author_facet	Alicia Sanchez-Mata Elena Gonzalez-Muñoz
author_sort	Alicia Sanchez-Mata
title	Understanding menstrual blood-derived stromal/stem cells: Definition and properties. Are we rushing into their therapeutic applications?
title_short	Understanding menstrual blood-derived stromal/stem cells: Definition and properties. Are we rushing into their therapeutic applications?
title_full	Understanding menstrual blood-derived stromal/stem cells: Definition and properties. Are we rushing into their therapeutic applications?
title_fullStr	Understanding menstrual blood-derived stromal/stem cells: Definition and properties. Are we rushing into their therapeutic applications?
title_full_unstemmed	Understanding menstrual blood-derived stromal/stem cells: Definition and properties. Are we rushing into their therapeutic applications?
title_sort	understanding menstrual blood-derived stromal/stem cells: definition and properties. are we rushing into their therapeutic applications?
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/1c03d3fe067f4cecba282faa6269e0e6
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Understanding menstrual blood-derived stromal/stem cells: Definition and properties. Are we rushing into their therapeutic applications?

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