Multi-unit relations among neural, self-report, and behavioral correlates of emotion regulation in comorbid depression and obesity

Abstract Depression is a leading cause of disability and is commonly comorbid with obesity. Emotion regulation is impaired in both depression and obesity. In this study, we aimed to explicate multi-unit relations among brain connectivity, behavior, and self-reported trait measures related to emotion...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Adam R. Pines, Matthew D. Sacchet, Monica Kullar, Jun Ma, Leanne M. Williams
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Comorbid Depression Uncinate Fasciculus Maladaptive Emotion Regulation Strategies Emotion Regulation Questionnaire (ERQ) Healthy Comparison Sample Medicine R Science Q
Acceso en línea:	https://doaj.org/article/1c0645e4f21c49c981d324522ba1724b
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:1c0645e4f21c49c981d324522ba1724b
record_format	dspace
spelling	oai:doaj.org-article:1c0645e4f21c49c981d324522ba1724b2021-12-02T15:09:08ZMulti-unit relations among neural, self-report, and behavioral correlates of emotion regulation in comorbid depression and obesity10.1038/s41598-018-32394-22045-2322https://doaj.org/article/1c0645e4f21c49c981d324522ba1724b2018-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-32394-2https://doaj.org/toc/2045-2322Abstract Depression is a leading cause of disability and is commonly comorbid with obesity. Emotion regulation is impaired in both depression and obesity. In this study, we aimed to explicate multi-unit relations among brain connectivity, behavior, and self-reported trait measures related to emotion regulation in a comorbid depressed and obese sample (N = 77). Brain connectivity was quantified as fractional anisotropy (FA) of the uncinate fasciculi, a white matter tract implicated in emotion regulation and in depression. Use of emotion regulation strategies was assessed using the Emotion Regulation Questionnaire (ERQ). We additionally measured reaction times to identifying negative emotions, a behavioral index of depression-related emotion processing biases. We found that greater right uncinate fasciculus FA was related to greater usage of suppression (r = 0.27, p = 0.022), and to faster reaction times to identifying negative emotions, particularly sadness (r = −0.30, p = 0.010) and fear (r = −0.35, p = 0.003). These findings suggest that FA of the right uncinate fasciculus corresponds to maladaptive emotion regulation strategies and emotion processing biases that are relevant to co-occurring depression and obesity. Interventions that consider these multi-unit associations may prove to be useful for subtyping and improving clinical outcomes for comorbid depression and obesity.Adam R. PinesMatthew D. SacchetMonica KullarJun MaLeanne M. WilliamsNature PortfolioarticleComorbid DepressionUncinate FasciculusMaladaptive Emotion Regulation StrategiesEmotion Regulation Questionnaire (ERQ)Healthy Comparison SampleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-11 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Comorbid Depression Uncinate Fasciculus Maladaptive Emotion Regulation Strategies Emotion Regulation Questionnaire (ERQ) Healthy Comparison Sample Medicine R Science Q
spellingShingle	Comorbid Depression Uncinate Fasciculus Maladaptive Emotion Regulation Strategies Emotion Regulation Questionnaire (ERQ) Healthy Comparison Sample Medicine R Science Q Adam R. Pines Matthew D. Sacchet Monica Kullar Jun Ma Leanne M. Williams Multi-unit relations among neural, self-report, and behavioral correlates of emotion regulation in comorbid depression and obesity
description	Abstract Depression is a leading cause of disability and is commonly comorbid with obesity. Emotion regulation is impaired in both depression and obesity. In this study, we aimed to explicate multi-unit relations among brain connectivity, behavior, and self-reported trait measures related to emotion regulation in a comorbid depressed and obese sample (N = 77). Brain connectivity was quantified as fractional anisotropy (FA) of the uncinate fasciculi, a white matter tract implicated in emotion regulation and in depression. Use of emotion regulation strategies was assessed using the Emotion Regulation Questionnaire (ERQ). We additionally measured reaction times to identifying negative emotions, a behavioral index of depression-related emotion processing biases. We found that greater right uncinate fasciculus FA was related to greater usage of suppression (r = 0.27, p = 0.022), and to faster reaction times to identifying negative emotions, particularly sadness (r = −0.30, p = 0.010) and fear (r = −0.35, p = 0.003). These findings suggest that FA of the right uncinate fasciculus corresponds to maladaptive emotion regulation strategies and emotion processing biases that are relevant to co-occurring depression and obesity. Interventions that consider these multi-unit associations may prove to be useful for subtyping and improving clinical outcomes for comorbid depression and obesity.
format	article
author	Adam R. Pines Matthew D. Sacchet Monica Kullar Jun Ma Leanne M. Williams
author_facet	Adam R. Pines Matthew D. Sacchet Monica Kullar Jun Ma Leanne M. Williams
author_sort	Adam R. Pines
title	Multi-unit relations among neural, self-report, and behavioral correlates of emotion regulation in comorbid depression and obesity
title_short	Multi-unit relations among neural, self-report, and behavioral correlates of emotion regulation in comorbid depression and obesity
title_full	Multi-unit relations among neural, self-report, and behavioral correlates of emotion regulation in comorbid depression and obesity
title_fullStr	Multi-unit relations among neural, self-report, and behavioral correlates of emotion regulation in comorbid depression and obesity
title_full_unstemmed	Multi-unit relations among neural, self-report, and behavioral correlates of emotion regulation in comorbid depression and obesity
title_sort	multi-unit relations among neural, self-report, and behavioral correlates of emotion regulation in comorbid depression and obesity
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/1c0645e4f21c49c981d324522ba1724b
work_keys_str_mv	AT adamrpines multiunitrelationsamongneuralselfreportandbehavioralcorrelatesofemotionregulationincomorbiddepressionandobesity AT matthewdsacchet multiunitrelationsamongneuralselfreportandbehavioralcorrelatesofemotionregulationincomorbiddepressionandobesity AT monicakullar multiunitrelationsamongneuralselfreportandbehavioralcorrelatesofemotionregulationincomorbiddepressionandobesity AT junma multiunitrelationsamongneuralselfreportandbehavioralcorrelatesofemotionregulationincomorbiddepressionandobesity AT leannemwilliams multiunitrelationsamongneuralselfreportandbehavioralcorrelatesofemotionregulationincomorbiddepressionandobesity
_version_	1718387860749418496

Multi-unit relations among neural, self-report, and behavioral correlates of emotion regulation in comorbid depression and obesity

Ejemplares similares