Comparison of the clinical features and outcomes in two age-groups of elderly patients with atrial fibrillation
Xing-Hui Shao,1 Yan-Min Yang,1 Jun Zhu,1 Han Zhang,1 Yao Liu,1 Xin Gao,1 Li-Tian Yu,1 Li-Sheng Liu,1 Li Zhao,2 Peng-Fei Yu,3 Hua Zhang,4 Qing He,5 Xiao-Dan Gu6 1Emergency and Intensive Care Center, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 2Depar...
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Dove Medical Press
2014
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oai:doaj.org-article:1c0738cc4aab4b50823148ad69f5824d2021-12-02T06:08:48ZComparison of the clinical features and outcomes in two age-groups of elderly patients with atrial fibrillation1178-1998https://doaj.org/article/1c0738cc4aab4b50823148ad69f5824d2014-08-01T00:00:00Zhttps://www.dovepress.com/comparison-of-the-clinical-features-and-outcomes-in-two-age-groups-of--peer-reviewed-article-CIAhttps://doaj.org/toc/1178-1998Xing-Hui Shao,1 Yan-Min Yang,1 Jun Zhu,1 Han Zhang,1 Yao Liu,1 Xin Gao,1 Li-Tian Yu,1 Li-Sheng Liu,1 Li Zhao,2 Peng-Fei Yu,3 Hua Zhang,4 Qing He,5 Xiao-Dan Gu6 1Emergency and Intensive Care Center, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 2Department of Emergency, Fu Xing Hospital, Capital Medical University, Beijing, 3Department of Cardiology, Pingdu People’s Hospital, Pingdu, 4Department of Emergency, Qingdao Municipal Hospital, Qingdao, 5Department of Emergency, West China Hospital, Sichuan University, Chengdu, 6Department of Emergency, Sixth People’s Hospital of Chengdu, Chengdu, People’s Republic of China Background: Atrial fibrillation (AF) disproportionately affects older adults. However, direct comparison of clinical features, medical therapy, and outcomes in AF patients aged 65–74 and ≥75 years is rare. The objective of the present study was to evaluate the differences in clinical characteristics and prognosis in these two age-groups of geriatric patients with AF.Materials and methods: A total of 1,336 individuals aged ≥65 years from a Chinese AF registry were assessed in the present study: 570 were in the 65- to 74-year group, and 766 were in the ≥75-year group. Multivariable Cox hazards regression was performed to analyze the major adverse cardiac events (MACEs) between groups.Results: In our population, the older group were more likely to have coronary artery disease, hypertension, previous stroke, cognitive disorder, or chronic obstructive pulmonary disease, and the 65- to 74-year group were more likely to have valvular heart disease, left ventricular systolic dysfunction, or sleep apnea. The older patients had 1.2-fold higher mean CHADS2 (congestive heart failure, hypertension, age ≥75 years, diabetes, stroke) scores, but less ­probability of being prescribed drugs. Compared with those aged 65–74 years, the older group had a higher risk of death (hazard ratio 2.881, 95% confidence interval 1.981–4.189; P<0.001) or MACE (hazard ratio 2.202, 95% confidence interval 1.646–2.945; P<0.001) at the 1-year follow-up. In multivariable Cox analyses, secondary AF diagnosis, a history of chronic obstructive pulmonary disease, and left ventricular systolic dysfunction were independent predictors of MACE in the older group.Conclusion: Patients aged ≥75 years had a worse prognosis than those aged 65–74 years, and were associated with a higher risk of both death and MACE. Keywords: atrial fibrillation, geriatric patients, mortality, major adverse cardiac events (MACE)Shao XHYang YMZhu JZhang HLiu YGao XYu LTLiu LSZhao LYu PFZhang HHe QGu XDDove Medical Pressarticleatrial fibrillationgeriatric patientsmortalitymajor adverse cardiac events (MACE)GeriatricsRC952-954.6ENClinical Interventions in Aging, Vol Volume 9, Pp 1335-1342 (2014) |
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DOAJ |
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atrial fibrillation geriatric patients mortality major adverse cardiac events (MACE) Geriatrics RC952-954.6 |
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atrial fibrillation geriatric patients mortality major adverse cardiac events (MACE) Geriatrics RC952-954.6 Shao XH Yang YM Zhu J Zhang H Liu Y Gao X Yu LT Liu LS Zhao L Yu PF Zhang H He Q Gu XD Comparison of the clinical features and outcomes in two age-groups of elderly patients with atrial fibrillation |
| description |
Xing-Hui Shao,1 Yan-Min Yang,1 Jun Zhu,1 Han Zhang,1 Yao Liu,1 Xin Gao,1 Li-Tian Yu,1 Li-Sheng Liu,1 Li Zhao,2 Peng-Fei Yu,3 Hua Zhang,4 Qing He,5 Xiao-Dan Gu6 1Emergency and Intensive Care Center, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 2Department of Emergency, Fu Xing Hospital, Capital Medical University, Beijing, 3Department of Cardiology, Pingdu People’s Hospital, Pingdu, 4Department of Emergency, Qingdao Municipal Hospital, Qingdao, 5Department of Emergency, West China Hospital, Sichuan University, Chengdu, 6Department of Emergency, Sixth People’s Hospital of Chengdu, Chengdu, People’s Republic of China Background: Atrial fibrillation (AF) disproportionately affects older adults. However, direct comparison of clinical features, medical therapy, and outcomes in AF patients aged 65–74 and ≥75 years is rare. The objective of the present study was to evaluate the differences in clinical characteristics and prognosis in these two age-groups of geriatric patients with AF.Materials and methods: A total of 1,336 individuals aged ≥65 years from a Chinese AF registry were assessed in the present study: 570 were in the 65- to 74-year group, and 766 were in the ≥75-year group. Multivariable Cox hazards regression was performed to analyze the major adverse cardiac events (MACEs) between groups.Results: In our population, the older group were more likely to have coronary artery disease, hypertension, previous stroke, cognitive disorder, or chronic obstructive pulmonary disease, and the 65- to 74-year group were more likely to have valvular heart disease, left ventricular systolic dysfunction, or sleep apnea. The older patients had 1.2-fold higher mean CHADS2 (congestive heart failure, hypertension, age ≥75 years, diabetes, stroke) scores, but less ­probability of being prescribed drugs. Compared with those aged 65–74 years, the older group had a higher risk of death (hazard ratio 2.881, 95% confidence interval 1.981–4.189; P<0.001) or MACE (hazard ratio 2.202, 95% confidence interval 1.646–2.945; P<0.001) at the 1-year follow-up. In multivariable Cox analyses, secondary AF diagnosis, a history of chronic obstructive pulmonary disease, and left ventricular systolic dysfunction were independent predictors of MACE in the older group.Conclusion: Patients aged ≥75 years had a worse prognosis than those aged 65–74 years, and were associated with a higher risk of both death and MACE. Keywords: atrial fibrillation, geriatric patients, mortality, major adverse cardiac events (MACE) |
| format |
article |
| author |
Shao XH Yang YM Zhu J Zhang H Liu Y Gao X Yu LT Liu LS Zhao L Yu PF Zhang H He Q Gu XD |
| author_facet |
Shao XH Yang YM Zhu J Zhang H Liu Y Gao X Yu LT Liu LS Zhao L Yu PF Zhang H He Q Gu XD |
| author_sort |
Shao XH |
| title |
Comparison of the clinical features and outcomes in two age-groups of elderly patients with atrial fibrillation |
| title_short |
Comparison of the clinical features and outcomes in two age-groups of elderly patients with atrial fibrillation |
| title_full |
Comparison of the clinical features and outcomes in two age-groups of elderly patients with atrial fibrillation |
| title_fullStr |
Comparison of the clinical features and outcomes in two age-groups of elderly patients with atrial fibrillation |
| title_full_unstemmed |
Comparison of the clinical features and outcomes in two age-groups of elderly patients with atrial fibrillation |
| title_sort |
comparison of the clinical features and outcomes in two age-groups of elderly patients with atrial fibrillation |
| publisher |
Dove Medical Press |
| publishDate |
2014 |
| url |
https://doaj.org/article/1c0738cc4aab4b50823148ad69f5824d |
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