Ocular manifestations of rheumatoid arthritis and their correlation with anti-cyclic citrullinated peptide antibodies

Ammapati Paul Pandian Vignesh, Renuka Srinivasan Department of Ophthalmology, Jawaharlal Institute of Postgraduate Medical Education and Research, Pondicherry, India Purpose: To study the ocular manifestations of rheumatoid arthritis and to correlate the role of anti-cyclic citrullinated...

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Autores principales:	Vignesh AP, Srinivasan R
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2015
Materias:	Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/1c0961c1d5fb4d24a8f159ee25814b6b
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spelling	oai:doaj.org-article:1c0961c1d5fb4d24a8f159ee25814b6b2021-12-02T02:08:45ZOcular manifestations of rheumatoid arthritis and their correlation with anti-cyclic citrullinated peptide antibodies1177-5483https://doaj.org/article/1c0961c1d5fb4d24a8f159ee25814b6b2015-02-01T00:00:00Zhttp://www.dovepress.com/ocular-manifestations-of-rheumatoid-arthritis-and-their-correlation-wi-peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483 Ammapati Paul Pandian Vignesh, Renuka Srinivasan Department of Ophthalmology, Jawaharlal Institute of Postgraduate Medical Education and Research, Pondicherry, India Purpose: To study the ocular manifestations of rheumatoid arthritis and to correlate the role of anti-cyclic citrullinated peptide antibody (anti-CCP antibody) with the ocular manifestations.Methods: Three-hundred and ninety-two eyes of the 196 rheumatoid arthritis patients who attended the ophthalmology outpatient department underwent a detailed ocular examination using slit lamp biomicroscopy and ophthalmoscopy. The tear function of all the patients was assessed using Schirmer’s test, tear film break-up time and ocular surface staining. The anti-CCP antibody titers for all the rheumatoid arthritis patients were estimated using enzyme-linked immunosorbent assay tests.Results: Seventy-seven patients (135 eyes, 39%) out of the 196 patients studied had ocular manifestations typical of rheumatoid arthritis. Dry eye was the most common manifestation (28%, 54 patients). Of the patients, 78% was females (60 patients). The mean duration of rheumatoid arthritis in patients with ocular manifestations was 5.4±2.7 years and without ocular manifestations was 2.1±1.6years. Three percent of the patients had episcleritis (six patients). Scleritis was present in 2% of the patients (four patients). Peripheral ulcerative keratitis and sclerosing keratitis was present in 1% of the population each (two patients each). Eighty-five percent (66 patients) had bilateral manifestations 15% (eleven patients) had unilateral manifestations. There was a strong association between the presence of anti-CCP antibodies and ocular manifestations of rheumatoid arthritis which was shown by the statistically significant P-value of <0.0001.Conclusion: Ocular manifestations are a significant part of the extra-articular manifestation of rheumatoid arthritis. Dry eye was the most common ocular manifestation. There was a statistically significant association between the presence of anti-CCP antibodies specific to rheumatoid arthritis and the ocular manifestations. Keywords: rheumatoid arthritis, ocular manifestations, anti-CCP antibodies, dry eye, scleritis, peripheral ulcerative keratitisVignesh APSrinivasan RDove Medical PressarticleOphthalmologyRE1-994ENClinical Ophthalmology, Vol 2015, Iss default, Pp 393-397 (2015)
institution	DOAJ
collection	DOAJ
language	EN
topic	Ophthalmology RE1-994
spellingShingle	Ophthalmology RE1-994 Vignesh AP Srinivasan R Ocular manifestations of rheumatoid arthritis and their correlation with anti-cyclic citrullinated peptide antibodies
description	Ammapati Paul Pandian Vignesh, Renuka Srinivasan Department of Ophthalmology, Jawaharlal Institute of Postgraduate Medical Education and Research, Pondicherry, India Purpose: To study the ocular manifestations of rheumatoid arthritis and to correlate the role of anti-cyclic citrullinated peptide antibody (anti-CCP antibody) with the ocular manifestations.Methods: Three-hundred and ninety-two eyes of the 196 rheumatoid arthritis patients who attended the ophthalmology outpatient department underwent a detailed ocular examination using slit lamp biomicroscopy and ophthalmoscopy. The tear function of all the patients was assessed using Schirmer’s test, tear film break-up time and ocular surface staining. The anti-CCP antibody titers for all the rheumatoid arthritis patients were estimated using enzyme-linked immunosorbent assay tests.Results: Seventy-seven patients (135 eyes, 39%) out of the 196 patients studied had ocular manifestations typical of rheumatoid arthritis. Dry eye was the most common manifestation (28%, 54 patients). Of the patients, 78% was females (60 patients). The mean duration of rheumatoid arthritis in patients with ocular manifestations was 5.4±2.7 years and without ocular manifestations was 2.1±1.6years. Three percent of the patients had episcleritis (six patients). Scleritis was present in 2% of the patients (four patients). Peripheral ulcerative keratitis and sclerosing keratitis was present in 1% of the population each (two patients each). Eighty-five percent (66 patients) had bilateral manifestations 15% (eleven patients) had unilateral manifestations. There was a strong association between the presence of anti-CCP antibodies and ocular manifestations of rheumatoid arthritis which was shown by the statistically significant P-value of <0.0001.Conclusion: Ocular manifestations are a significant part of the extra-articular manifestation of rheumatoid arthritis. Dry eye was the most common ocular manifestation. There was a statistically significant association between the presence of anti-CCP antibodies specific to rheumatoid arthritis and the ocular manifestations. Keywords: rheumatoid arthritis, ocular manifestations, anti-CCP antibodies, dry eye, scleritis, peripheral ulcerative keratitis
format	article
author	Vignesh AP Srinivasan R
author_facet	Vignesh AP Srinivasan R
author_sort	Vignesh AP
title	Ocular manifestations of rheumatoid arthritis and their correlation with anti-cyclic citrullinated peptide antibodies
title_short	Ocular manifestations of rheumatoid arthritis and their correlation with anti-cyclic citrullinated peptide antibodies
title_full	Ocular manifestations of rheumatoid arthritis and their correlation with anti-cyclic citrullinated peptide antibodies
title_fullStr	Ocular manifestations of rheumatoid arthritis and their correlation with anti-cyclic citrullinated peptide antibodies
title_full_unstemmed	Ocular manifestations of rheumatoid arthritis and their correlation with anti-cyclic citrullinated peptide antibodies
title_sort	ocular manifestations of rheumatoid arthritis and their correlation with anti-cyclic citrullinated peptide antibodies
publisher	Dove Medical Press
publishDate	2015
url	https://doaj.org/article/1c0961c1d5fb4d24a8f159ee25814b6b
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Ocular manifestations of rheumatoid arthritis and their correlation with anti-cyclic citrullinated peptide antibodies

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