Correlation of intra-tumor 18F-FDG uptake heterogeneity indices with perfusion CT derived parameters in colorectal cancer.
<h4>Methods</h4>Thirty patients with proven colorectal cancer prospectively underwent integrated 18F-FDG PET/DCE-CT to assess the metabolic-flow phenotype. Both CT blood flow parametric maps and PET images were analyzed. Correlations between PET heterogeneity and perfusion CT were assess...
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2014
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oai:doaj.org-article:1c0b78e5fb4949548a116d31f3e0cb0a2021-11-18T08:15:41ZCorrelation of intra-tumor 18F-FDG uptake heterogeneity indices with perfusion CT derived parameters in colorectal cancer.1932-620310.1371/journal.pone.0099567https://doaj.org/article/1c0b78e5fb4949548a116d31f3e0cb0a2014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24926986/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Methods</h4>Thirty patients with proven colorectal cancer prospectively underwent integrated 18F-FDG PET/DCE-CT to assess the metabolic-flow phenotype. Both CT blood flow parametric maps and PET images were analyzed. Correlations between PET heterogeneity and perfusion CT were assessed by Spearman's rank correlation analysis.<h4>Results</h4>Blood flow visualization provided by DCE-CT images was significantly correlated with 18F-FDG PET metabolically active tumor volume as well as with uptake heterogeneity for patients with stage III/IV tumors (|ρ|:0.66 to 0.78; p-value<0.02).<h4>Conclusion</h4>The positive correlation found with tumor blood flow indicates that intra-tumor heterogeneity of 18F-FDG PET accumulation reflects to some extent tracer distribution and consequently indicates that 18F-FDG PET intra-tumor heterogeneity may be associated with physiological processes such as tumor vascularization.Florent TixierAshley M GrovesVicky GohMathieu HattPierre IngrandCatherine Cheze Le RestDimitris VisvikisPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 6, p e99567 (2014) |
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DOAJ |
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EN |
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Medicine R Science Q |
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Medicine R Science Q Florent Tixier Ashley M Groves Vicky Goh Mathieu Hatt Pierre Ingrand Catherine Cheze Le Rest Dimitris Visvikis Correlation of intra-tumor 18F-FDG uptake heterogeneity indices with perfusion CT derived parameters in colorectal cancer. |
| description |
<h4>Methods</h4>Thirty patients with proven colorectal cancer prospectively underwent integrated 18F-FDG PET/DCE-CT to assess the metabolic-flow phenotype. Both CT blood flow parametric maps and PET images were analyzed. Correlations between PET heterogeneity and perfusion CT were assessed by Spearman's rank correlation analysis.<h4>Results</h4>Blood flow visualization provided by DCE-CT images was significantly correlated with 18F-FDG PET metabolically active tumor volume as well as with uptake heterogeneity for patients with stage III/IV tumors (|ρ|:0.66 to 0.78; p-value<0.02).<h4>Conclusion</h4>The positive correlation found with tumor blood flow indicates that intra-tumor heterogeneity of 18F-FDG PET accumulation reflects to some extent tracer distribution and consequently indicates that 18F-FDG PET intra-tumor heterogeneity may be associated with physiological processes such as tumor vascularization. |
| format |
article |
| author |
Florent Tixier Ashley M Groves Vicky Goh Mathieu Hatt Pierre Ingrand Catherine Cheze Le Rest Dimitris Visvikis |
| author_facet |
Florent Tixier Ashley M Groves Vicky Goh Mathieu Hatt Pierre Ingrand Catherine Cheze Le Rest Dimitris Visvikis |
| author_sort |
Florent Tixier |
| title |
Correlation of intra-tumor 18F-FDG uptake heterogeneity indices with perfusion CT derived parameters in colorectal cancer. |
| title_short |
Correlation of intra-tumor 18F-FDG uptake heterogeneity indices with perfusion CT derived parameters in colorectal cancer. |
| title_full |
Correlation of intra-tumor 18F-FDG uptake heterogeneity indices with perfusion CT derived parameters in colorectal cancer. |
| title_fullStr |
Correlation of intra-tumor 18F-FDG uptake heterogeneity indices with perfusion CT derived parameters in colorectal cancer. |
| title_full_unstemmed |
Correlation of intra-tumor 18F-FDG uptake heterogeneity indices with perfusion CT derived parameters in colorectal cancer. |
| title_sort |
correlation of intra-tumor 18f-fdg uptake heterogeneity indices with perfusion ct derived parameters in colorectal cancer. |
| publisher |
Public Library of Science (PLoS) |
| publishDate |
2014 |
| url |
https://doaj.org/article/1c0b78e5fb4949548a116d31f3e0cb0a |
| work_keys_str_mv |
AT florenttixier correlationofintratumor18ffdguptakeheterogeneityindiceswithperfusionctderivedparametersincolorectalcancer AT ashleymgroves correlationofintratumor18ffdguptakeheterogeneityindiceswithperfusionctderivedparametersincolorectalcancer AT vickygoh correlationofintratumor18ffdguptakeheterogeneityindiceswithperfusionctderivedparametersincolorectalcancer AT mathieuhatt correlationofintratumor18ffdguptakeheterogeneityindiceswithperfusionctderivedparametersincolorectalcancer AT pierreingrand correlationofintratumor18ffdguptakeheterogeneityindiceswithperfusionctderivedparametersincolorectalcancer AT catherinechezelerest correlationofintratumor18ffdguptakeheterogeneityindiceswithperfusionctderivedparametersincolorectalcancer AT dimitrisvisvikis correlationofintratumor18ffdguptakeheterogeneityindiceswithperfusionctderivedparametersincolorectalcancer |
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