Fibrinogen and fibrin based micro and nano scaffolds incorporated with drugs, proteins, cells and genes for therapeutic biomedical applications

Thanavel Rajangam, Seong Soo A An Department of Bionanotechnology, Gachon University, Seongnam-Si, Republic of Korea Abstract: Over the past two decades, many types of natural and synthetic polymer-based micro- and nanocarriers, with exciting properties and applications, have been developed for appl...

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Autores principales:	Rajangam T, An SSA
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2013
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/1c0bba1cb03446659bc19f75ffc6a8c5
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spelling	oai:doaj.org-article:1c0bba1cb03446659bc19f75ffc6a8c52021-12-02T05:15:15ZFibrinogen and fibrin based micro and nano scaffolds incorporated with drugs, proteins, cells and genes for therapeutic biomedical applications1176-91141178-2013https://doaj.org/article/1c0bba1cb03446659bc19f75ffc6a8c52013-09-01T00:00:00Zhttp://www.dovepress.com/fibrinogen-and-fibrin-based-micro-and-nano-scaffolds-incorporated-with-a14485https://doaj.org/toc/1176-9114https://doaj.org/toc/1178-2013Thanavel Rajangam, Seong Soo A An Department of Bionanotechnology, Gachon University, Seongnam-Si, Republic of Korea Abstract: Over the past two decades, many types of natural and synthetic polymer-based micro- and nanocarriers, with exciting properties and applications, have been developed for application in various types of tissue regeneration, including bone, cartilage, nerve, blood vessels, and skin. The development of suitable polymers scaffold designs to aid the repair of specific cell types have created diverse and important potentials in tissue restoration. Fibrinogen (Fbg)- and fibrin (Fbn)-based micro- and nanostructures can provide suitable natural matrix environments. Since these primary materials are abundantly available in blood as the main coagulation proteins, they can easily interact with damaged tissues and cells through native biochemical interactions. Fbg- and Fbn-based micro and nanostructures can also be consecutively furnished/or encapsulated and specifically delivered, with multiple growth factors, proteins, and stem cells, in structures designed to aid in specific phases of the tissue regeneration process. The present review has been carried out to demonstrate the progress made with micro and nanoscaffold applications and features a number of applications of Fbg- and Fbn-based carriers in the field of biomaterials, including the delivery of drugs, active biomolecules, cells, and genes, that have been effectively used in tissue engineering and regenerative medicine. Keywords: biomaterial, polymer composite, cross-linking, growth factor, drug delivery, controlled release, tissue regenerationRajangam TAn SSADove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2013, Iss Issue 1, Pp 3641-3662 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Rajangam T An SSA Fibrinogen and fibrin based micro and nano scaffolds incorporated with drugs, proteins, cells and genes for therapeutic biomedical applications
description	Thanavel Rajangam, Seong Soo A An Department of Bionanotechnology, Gachon University, Seongnam-Si, Republic of Korea Abstract: Over the past two decades, many types of natural and synthetic polymer-based micro- and nanocarriers, with exciting properties and applications, have been developed for application in various types of tissue regeneration, including bone, cartilage, nerve, blood vessels, and skin. The development of suitable polymers scaffold designs to aid the repair of specific cell types have created diverse and important potentials in tissue restoration. Fibrinogen (Fbg)- and fibrin (Fbn)-based micro- and nanostructures can provide suitable natural matrix environments. Since these primary materials are abundantly available in blood as the main coagulation proteins, they can easily interact with damaged tissues and cells through native biochemical interactions. Fbg- and Fbn-based micro and nanostructures can also be consecutively furnished/or encapsulated and specifically delivered, with multiple growth factors, proteins, and stem cells, in structures designed to aid in specific phases of the tissue regeneration process. The present review has been carried out to demonstrate the progress made with micro and nanoscaffold applications and features a number of applications of Fbg- and Fbn-based carriers in the field of biomaterials, including the delivery of drugs, active biomolecules, cells, and genes, that have been effectively used in tissue engineering and regenerative medicine. Keywords: biomaterial, polymer composite, cross-linking, growth factor, drug delivery, controlled release, tissue regeneration
format	article
author	Rajangam T An SSA
author_facet	Rajangam T An SSA
author_sort	Rajangam T
title	Fibrinogen and fibrin based micro and nano scaffolds incorporated with drugs, proteins, cells and genes for therapeutic biomedical applications
title_short	Fibrinogen and fibrin based micro and nano scaffolds incorporated with drugs, proteins, cells and genes for therapeutic biomedical applications
title_full	Fibrinogen and fibrin based micro and nano scaffolds incorporated with drugs, proteins, cells and genes for therapeutic biomedical applications
title_fullStr	Fibrinogen and fibrin based micro and nano scaffolds incorporated with drugs, proteins, cells and genes for therapeutic biomedical applications
title_full_unstemmed	Fibrinogen and fibrin based micro and nano scaffolds incorporated with drugs, proteins, cells and genes for therapeutic biomedical applications
title_sort	fibrinogen and fibrin based micro and nano scaffolds incorporated with drugs, proteins, cells and genes for therapeutic biomedical applications
publisher	Dove Medical Press
publishDate	2013
url	https://doaj.org/article/1c0bba1cb03446659bc19f75ffc6a8c5
work_keys_str_mv	AT rajangamt fibrinogenandfibrinbasedmicroandnanoscaffoldsincorporatedwithdrugsproteinscellsandgenesfortherapeuticbiomedicalapplications AT anssa fibrinogenandfibrinbasedmicroandnanoscaffoldsincorporatedwithdrugsproteinscellsandgenesfortherapeuticbiomedicalapplications
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Fibrinogen and fibrin based micro and nano scaffolds incorporated with drugs, proteins, cells and genes for therapeutic biomedical applications

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