Possible therapeutic effect of royal jelly on endometriotic lesion size, pain sensitivity, and neurotrophic factors in a rat model of endometriosis

Abstract Endometriosis is the abnormal growth of endometrial tissue. The goals of the study are: (1) Is any correlation between endometriosis pain and neurotrophins in the serum, dorsal root ganglion (DRG), and peritoneal fluid (PF) in rat models of experimental endometriosis?, (2) Possible therapeu...

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Autores principales:	Zahra K. Farahani, Mahnaz Taherianfard, Mohamad Mehdi Naderi, Hortensia Ferrero
Formato:	article
Lenguaje:	EN
Publicado:	Wiley 2021
Materias:	endometriosis lesion size neurotrophic factor pain royal jelly Physiology QP1-981
Acceso en línea:	https://doaj.org/article/1c10410ccbed487e96ebd1e195dab75b
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spelling	oai:doaj.org-article:1c10410ccbed487e96ebd1e195dab75b2021-11-27T15:48:30ZPossible therapeutic effect of royal jelly on endometriotic lesion size, pain sensitivity, and neurotrophic factors in a rat model of endometriosis2051-817X10.14814/phy2.15117https://doaj.org/article/1c10410ccbed487e96ebd1e195dab75b2021-11-01T00:00:00Zhttps://doi.org/10.14814/phy2.15117https://doaj.org/toc/2051-817XAbstract Endometriosis is the abnormal growth of endometrial tissue. The goals of the study are: (1) Is any correlation between endometriosis pain and neurotrophins in the serum, dorsal root ganglion (DRG), and peritoneal fluid (PF) in rat models of experimental endometriosis?, (2) Possible therapeutic effects of royal jelly (RJ) on pain scores, size of endometriotic lesion, and neurotrophic factors. Forty‐eight Sprague Dawley female rats weighing 205.023 ± 21.54 g were maintained in a standard condition. The rats were randomly divided into one of the six groups: Control (no intervention), Sham‐1 (remove of uterine horn), RJ (administration of 200 mg/kg/day RJ for 21 days), Endometriosis (induction of endometriosis), Treatment (induction of endometriosis+administration of 200 mg/kg/day RJ for 21 days), and Sham‐2 (induction of endometriosis+administration of water). Formalin test performed for pain evaluation. The levels of Brain‐derived neurotrophic factor (BDNF), nerve growth factor (NGF), substance P, and calcitonin gene‐related peptide (CGRP) were measured by enzyme‐linked immunosorbent assay. The mean pain scores in all three phases of the formalin test were significantly increased by endometriosis induction (p < 0.05). The concentrations of BDNF, NGF, and CGRP in DRG of the endometriosis group were significantly higher than these factors in the Control, Sham‐1, and RJ groups (p < 0.05). RJ could significantly (p < 0.001) decrease the mean lesion size and the mean pain score in the late phase (p < 0.05). The present results determine that endometriosis pain may be related to nervous system neurotrophic factors. Treatment with RJ could decrease the size of endometriosis lesions as well as pain scores. The findings may shed light on other complementary and alternative remedies for endometriosis.Zahra K. FarahaniMahnaz TaherianfardMohamad Mehdi NaderiHortensia FerreroWileyarticleendometriosislesion sizeneurotrophic factorpainroyal jellyPhysiologyQP1-981ENPhysiological Reports, Vol 9, Iss 22, Pp n/a-n/a (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	endometriosis lesion size neurotrophic factor pain royal jelly Physiology QP1-981
spellingShingle	endometriosis lesion size neurotrophic factor pain royal jelly Physiology QP1-981 Zahra K. Farahani Mahnaz Taherianfard Mohamad Mehdi Naderi Hortensia Ferrero Possible therapeutic effect of royal jelly on endometriotic lesion size, pain sensitivity, and neurotrophic factors in a rat model of endometriosis
description	Abstract Endometriosis is the abnormal growth of endometrial tissue. The goals of the study are: (1) Is any correlation between endometriosis pain and neurotrophins in the serum, dorsal root ganglion (DRG), and peritoneal fluid (PF) in rat models of experimental endometriosis?, (2) Possible therapeutic effects of royal jelly (RJ) on pain scores, size of endometriotic lesion, and neurotrophic factors. Forty‐eight Sprague Dawley female rats weighing 205.023 ± 21.54 g were maintained in a standard condition. The rats were randomly divided into one of the six groups: Control (no intervention), Sham‐1 (remove of uterine horn), RJ (administration of 200 mg/kg/day RJ for 21 days), Endometriosis (induction of endometriosis), Treatment (induction of endometriosis+administration of 200 mg/kg/day RJ for 21 days), and Sham‐2 (induction of endometriosis+administration of water). Formalin test performed for pain evaluation. The levels of Brain‐derived neurotrophic factor (BDNF), nerve growth factor (NGF), substance P, and calcitonin gene‐related peptide (CGRP) were measured by enzyme‐linked immunosorbent assay. The mean pain scores in all three phases of the formalin test were significantly increased by endometriosis induction (p < 0.05). The concentrations of BDNF, NGF, and CGRP in DRG of the endometriosis group were significantly higher than these factors in the Control, Sham‐1, and RJ groups (p < 0.05). RJ could significantly (p < 0.001) decrease the mean lesion size and the mean pain score in the late phase (p < 0.05). The present results determine that endometriosis pain may be related to nervous system neurotrophic factors. Treatment with RJ could decrease the size of endometriosis lesions as well as pain scores. The findings may shed light on other complementary and alternative remedies for endometriosis.
format	article
author	Zahra K. Farahani Mahnaz Taherianfard Mohamad Mehdi Naderi Hortensia Ferrero
author_facet	Zahra K. Farahani Mahnaz Taherianfard Mohamad Mehdi Naderi Hortensia Ferrero
author_sort	Zahra K. Farahani
title	Possible therapeutic effect of royal jelly on endometriotic lesion size, pain sensitivity, and neurotrophic factors in a rat model of endometriosis
title_short	Possible therapeutic effect of royal jelly on endometriotic lesion size, pain sensitivity, and neurotrophic factors in a rat model of endometriosis
title_full	Possible therapeutic effect of royal jelly on endometriotic lesion size, pain sensitivity, and neurotrophic factors in a rat model of endometriosis
title_fullStr	Possible therapeutic effect of royal jelly on endometriotic lesion size, pain sensitivity, and neurotrophic factors in a rat model of endometriosis
title_full_unstemmed	Possible therapeutic effect of royal jelly on endometriotic lesion size, pain sensitivity, and neurotrophic factors in a rat model of endometriosis
title_sort	possible therapeutic effect of royal jelly on endometriotic lesion size, pain sensitivity, and neurotrophic factors in a rat model of endometriosis
publisher	Wiley
publishDate	2021
url	https://doaj.org/article/1c10410ccbed487e96ebd1e195dab75b
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_version_	1718408486165938176

Possible therapeutic effect of royal jelly on endometriotic lesion size, pain sensitivity, and neurotrophic factors in a rat model of endometriosis

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