Synthesis of Isatin and its derivatives containing heterocyclic compounds
Isatin or 1H-indole-2,3-dione or 2,3-dioxindole is an indole derivative. Isatin and its analogs are synthetically useful substances where they may be utilized for the production of a broad range of heterocyclic molecules, which are depicting a wide reach of biological and pharmacological activities,...
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Turkish Chemical Society
2021
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oai:doaj.org-article:1c1663ae541d495a81d2fc74bcbfcd192021-11-20T10:10:33Z Synthesis of Isatin and its derivatives containing heterocyclic compounds https://doi.org/10.18596/jotcsa.9622602149-0120https://doaj.org/article/1c1663ae541d495a81d2fc74bcbfcd192021-11-01T00:00:00Zhttps://dergipark.org.tr/tr/pub/jotcsa/issue/64621/962260https://doaj.org/toc/2149-0120Isatin or 1H-indole-2,3-dione or 2,3-dioxindole is an indole derivative. Isatin and its analogs are synthetically useful substances where they may be utilized for the production of a broad range of heterocyclic molecules, which are depicting a wide reach of biological and pharmacological activities, as well as anticancer, anti-inflammatory, antiviral, anticonvulsant, anti-TB, antidiabetic, anti-microbial, antitumor, antimalarial, anti-HIV, antibacterial, anti-analgesic, and antiplasmodial activities. Isatin is a precursor for many synthesized therapeutic molecules that are amenable to pharmacological action and have excellent biological potential. Isatin has a magnificent scaffold for both the natural and synthetic construction of molecules. These molecules are being used in drug therapy such as anticancer, antibiotic, and antidepressant drugs and have many more clinical applications. Due to its privileged scaffolding, the synthetic versatility of isatin has produced many structurally diverse derivatives, including the substitution of mono-, di- and tri- substitution of the aryl rings A and those derived by derivation of isatin nitrogen and C2 and C3 carbon moieties. As a result, improving and expediting access to isatin-related molecules is a challenging study in synthetic organic chemistry.Pratibha MİSHRAArunesh MİSHRAAnil Kumar BAHEAtish ROYRatnesh DASTurkish Chemical Societyarticleisatin1h-indole-23-dioneheterocyclic compoundsanticanceranti-inflammatoryantimalariaanti-hivdrug therapyChemistryQD1-999ENJournal of the Turkish Chemical Society, Section A: Chemistry, Vol 8, Iss 4, Pp 1089 -1098 (2021) |
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DOAJ |
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DOAJ |
| language |
EN |
| topic |
isatin 1h-indole-2 3-dione heterocyclic compounds anticancer anti-inflammatory antimalaria anti-hiv drug therapy Chemistry QD1-999 |
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isatin 1h-indole-2 3-dione heterocyclic compounds anticancer anti-inflammatory antimalaria anti-hiv drug therapy Chemistry QD1-999 Pratibha MİSHRA Arunesh MİSHRA Anil Kumar BAHE Atish ROY Ratnesh DAS Synthesis of Isatin and its derivatives containing heterocyclic compounds |
| description |
Isatin or 1H-indole-2,3-dione or 2,3-dioxindole is an indole derivative. Isatin and its analogs are synthetically useful substances where they may be utilized for the production of a broad range of heterocyclic molecules, which are depicting a wide reach of biological and pharmacological activities, as well as anticancer, anti-inflammatory, antiviral, anticonvulsant, anti-TB, antidiabetic, anti-microbial, antitumor, antimalarial, anti-HIV, antibacterial, anti-analgesic, and antiplasmodial activities. Isatin is a precursor for many synthesized therapeutic molecules that are amenable to pharmacological action and have excellent biological potential. Isatin has a magnificent scaffold for both the natural and synthetic construction of molecules. These molecules are being used in drug therapy such as anticancer, antibiotic, and antidepressant drugs and have many more clinical applications. Due to its privileged scaffolding, the synthetic versatility of isatin has produced many structurally diverse derivatives, including the substitution of mono-, di- and tri- substitution of the aryl rings A and those derived by derivation of isatin nitrogen and C2 and C3 carbon moieties. As a result, improving and expediting access to isatin-related molecules is a challenging study in synthetic organic chemistry. |
| format |
article |
| author |
Pratibha MİSHRA Arunesh MİSHRA Anil Kumar BAHE Atish ROY Ratnesh DAS |
| author_facet |
Pratibha MİSHRA Arunesh MİSHRA Anil Kumar BAHE Atish ROY Ratnesh DAS |
| author_sort |
Pratibha MİSHRA |
| title |
Synthesis of Isatin and its derivatives containing heterocyclic compounds |
| title_short |
Synthesis of Isatin and its derivatives containing heterocyclic compounds |
| title_full |
Synthesis of Isatin and its derivatives containing heterocyclic compounds |
| title_fullStr |
Synthesis of Isatin and its derivatives containing heterocyclic compounds |
| title_full_unstemmed |
Synthesis of Isatin and its derivatives containing heterocyclic compounds |
| title_sort |
synthesis of isatin and its derivatives containing heterocyclic compounds |
| publisher |
Turkish Chemical Society |
| publishDate |
2021 |
| url |
https://doi.org/10.18596/jotcsa.962260 https://doaj.org/article/1c1663ae541d495a81d2fc74bcbfcd19 |
| work_keys_str_mv |
AT pratibhamishra synthesisofisatinanditsderivativescontainingheterocycliccompounds AT aruneshmishra synthesisofisatinanditsderivativescontainingheterocycliccompounds AT anilkumarbahe synthesisofisatinanditsderivativescontainingheterocycliccompounds AT atishroy synthesisofisatinanditsderivativescontainingheterocycliccompounds AT ratneshdas synthesisofisatinanditsderivativescontainingheterocycliccompounds |
| _version_ |
1718419410594562048 |