Cardiovascular risk factors associated with acute myocardial infarction and stroke in the MADIABETES cohort

Abstract We aimed to develop two models to estimate first AMI and stroke/TIA, respectively, in type 2 diabetes mellitus patients, by applying backward elimination to the following variables: age, sex, duration of diabetes, smoking, BMI, and use of antihyperglycemic drugs, statins, and aspirin. As ti...

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Autores principales:	M. A. Salinero-Fort, F. J. San Andrés-Rebollo, J. Cárdenas-Valladolid, M. Méndez-Bailón, R. M. Chico-Moraleja, E. Carrillo de Santa Pau, I. Jiménez-Trujillo, I. Gómez-Campelo, C. de Burgos Lunar, J. M. de Miguel-Yanes, MADIABETES
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/1c1b8637558d42d3b5690dd470e6c6a3
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spelling	oai:doaj.org-article:1c1b8637558d42d3b5690dd470e6c6a32021-12-02T16:06:44ZCardiovascular risk factors associated with acute myocardial infarction and stroke in the MADIABETES cohort10.1038/s41598-021-94121-82045-2322https://doaj.org/article/1c1b8637558d42d3b5690dd470e6c6a32021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-94121-8https://doaj.org/toc/2045-2322Abstract We aimed to develop two models to estimate first AMI and stroke/TIA, respectively, in type 2 diabetes mellitus patients, by applying backward elimination to the following variables: age, sex, duration of diabetes, smoking, BMI, and use of antihyperglycemic drugs, statins, and aspirin. As time-varying covariates, we analyzed blood pressure, albuminuria, lipid profile, HbA1c, retinopathy, neuropathy, and atrial fibrillation (only in stroke/TIA model). Both models were stratified by antihypertensive drugs. We evaluated 2980 patients (52.8% women; 67.3 ± 11.2 years) with 24,159 person-years of follow-up. We recorded 114 cases of AMI and 185 cases of stroke/TIA. The factors that were independently associated with first AMI were age (≥ 75 years vs. < 75 years) (p = 0.019), higher HbA1c (> 64 mmol/mol vs. < 53 mmol/mol) (p = 0.003), HDL-cholesterol (0.90–1.81 mmol/L vs. < 0.90 mmol/L) (p = 0.002), and diastolic blood pressure (65–85 mmHg vs. < 65 mmHg) (p < 0.001). The factors that were independently associated with first stroke/TIA were age (≥ 75 years vs. < 60 years) (p < 0.001), atrial fibrillation (first year after the diagnosis vs. more than one year) (p = 0.001), glomerular filtration rate (per each 15 mL/min/1.73 m2 decrease) (p < 0.001), total cholesterol (3.88–6.46 mmol/L vs. < 3.88 mmol/L) (p < 0.001), triglycerides (per each increment of 1.13 mmol/L) (p = 0.031), albuminuria (p < 0.001), neuropathy (p = 0.01), and retinopathy (p = 0.023).M. A. Salinero-FortF. J. San Andrés-RebolloJ. Cárdenas-ValladolidM. Méndez-BailónR. M. Chico-MoralejaE. Carrillo de Santa PauI. Jiménez-TrujilloI. Gómez-CampeloC. de Burgos LunarJ. M. de Miguel-YanesMADIABETESNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q M. A. Salinero-Fort F. J. San Andrés-Rebollo J. Cárdenas-Valladolid M. Méndez-Bailón R. M. Chico-Moraleja E. Carrillo de Santa Pau I. Jiménez-Trujillo I. Gómez-Campelo C. de Burgos Lunar J. M. de Miguel-Yanes MADIABETES Cardiovascular risk factors associated with acute myocardial infarction and stroke in the MADIABETES cohort
description	Abstract We aimed to develop two models to estimate first AMI and stroke/TIA, respectively, in type 2 diabetes mellitus patients, by applying backward elimination to the following variables: age, sex, duration of diabetes, smoking, BMI, and use of antihyperglycemic drugs, statins, and aspirin. As time-varying covariates, we analyzed blood pressure, albuminuria, lipid profile, HbA1c, retinopathy, neuropathy, and atrial fibrillation (only in stroke/TIA model). Both models were stratified by antihypertensive drugs. We evaluated 2980 patients (52.8% women; 67.3 ± 11.2 years) with 24,159 person-years of follow-up. We recorded 114 cases of AMI and 185 cases of stroke/TIA. The factors that were independently associated with first AMI were age (≥ 75 years vs. < 75 years) (p = 0.019), higher HbA1c (> 64 mmol/mol vs. < 53 mmol/mol) (p = 0.003), HDL-cholesterol (0.90–1.81 mmol/L vs. < 0.90 mmol/L) (p = 0.002), and diastolic blood pressure (65–85 mmHg vs. < 65 mmHg) (p < 0.001). The factors that were independently associated with first stroke/TIA were age (≥ 75 years vs. < 60 years) (p < 0.001), atrial fibrillation (first year after the diagnosis vs. more than one year) (p = 0.001), glomerular filtration rate (per each 15 mL/min/1.73 m2 decrease) (p < 0.001), total cholesterol (3.88–6.46 mmol/L vs. < 3.88 mmol/L) (p < 0.001), triglycerides (per each increment of 1.13 mmol/L) (p = 0.031), albuminuria (p < 0.001), neuropathy (p = 0.01), and retinopathy (p = 0.023).
format	article
author	M. A. Salinero-Fort F. J. San Andrés-Rebollo J. Cárdenas-Valladolid M. Méndez-Bailón R. M. Chico-Moraleja E. Carrillo de Santa Pau I. Jiménez-Trujillo I. Gómez-Campelo C. de Burgos Lunar J. M. de Miguel-Yanes MADIABETES
author_facet	M. A. Salinero-Fort F. J. San Andrés-Rebollo J. Cárdenas-Valladolid M. Méndez-Bailón R. M. Chico-Moraleja E. Carrillo de Santa Pau I. Jiménez-Trujillo I. Gómez-Campelo C. de Burgos Lunar J. M. de Miguel-Yanes MADIABETES
author_sort	M. A. Salinero-Fort
title	Cardiovascular risk factors associated with acute myocardial infarction and stroke in the MADIABETES cohort
title_short	Cardiovascular risk factors associated with acute myocardial infarction and stroke in the MADIABETES cohort
title_full	Cardiovascular risk factors associated with acute myocardial infarction and stroke in the MADIABETES cohort
title_fullStr	Cardiovascular risk factors associated with acute myocardial infarction and stroke in the MADIABETES cohort
title_full_unstemmed	Cardiovascular risk factors associated with acute myocardial infarction and stroke in the MADIABETES cohort
title_sort	cardiovascular risk factors associated with acute myocardial infarction and stroke in the madiabetes cohort
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/1c1b8637558d42d3b5690dd470e6c6a3
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Cardiovascular risk factors associated with acute myocardial infarction and stroke in the MADIABETES cohort

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