Testing hypotheses of developmental constraints on mammalian brain partition evolution, using marsupials

Abstract There is considerable debate about whether the partition volumes of the mammalian brain (e.g. cerebrum, cerebellum) evolve according to functional selection, or whether developmental constraints of conserved neurogenetic scheduling cause predictable partition scaling with brain size. Here w...

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Autores principales:	Alison Carlisle, Lynne Selwood, Lyn A. Hinds, Norman Saunders, Mark Habgood, Karine Mardon, Vera Weisbecker
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/1c1c2afdf1e34f749d418eaf38c99573
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spelling	oai:doaj.org-article:1c1c2afdf1e34f749d418eaf38c995732021-12-02T16:06:42ZTesting hypotheses of developmental constraints on mammalian brain partition evolution, using marsupials10.1038/s41598-017-02726-92045-2322https://doaj.org/article/1c1c2afdf1e34f749d418eaf38c995732017-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-02726-9https://doaj.org/toc/2045-2322Abstract There is considerable debate about whether the partition volumes of the mammalian brain (e.g. cerebrum, cerebellum) evolve according to functional selection, or whether developmental constraints of conserved neurogenetic scheduling cause predictable partition scaling with brain size. Here we provide the first investigation of developmental constraints on partition volume growth, derived from contrast-enhanced micro-computed tomography of hydrogel-stabilized brains from three marsupial species. ANCOVAs of partition vs. brain volume scaling, as well as growth curve comparisons, do not support several hypotheses consistent with developmental constraints: brain partition growth significantly differs between species, or between developing vs. adult marsupials. Partition growth appears independent of adult brain volume, with no discernable growth spurts/lags relatable to internal structural change. Rather, adult proportion differences appear to arise through growth rate/duration heterochrony. Substantial phylogenetic signal in adult brain partitions scaling with brain volume also counters expectations of development-mediated partition scaling conservatism. However, the scaling of olfactory bulb growth is markedly irregular, consistent with suggestions that it is less constrained. The very regular partition growth curves suggest intraspecific developmental rigidity. We speculate that a rigid, possibly neuromer-model-like early molecular program might be responsible both for regular growth curves within species and impressions of a link between neurogenesis and partition evolution.Alison CarlisleLynne SelwoodLyn A. HindsNorman SaundersMark HabgoodKarine MardonVera WeisbeckerNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Alison Carlisle Lynne Selwood Lyn A. Hinds Norman Saunders Mark Habgood Karine Mardon Vera Weisbecker Testing hypotheses of developmental constraints on mammalian brain partition evolution, using marsupials
description	Abstract There is considerable debate about whether the partition volumes of the mammalian brain (e.g. cerebrum, cerebellum) evolve according to functional selection, or whether developmental constraints of conserved neurogenetic scheduling cause predictable partition scaling with brain size. Here we provide the first investigation of developmental constraints on partition volume growth, derived from contrast-enhanced micro-computed tomography of hydrogel-stabilized brains from three marsupial species. ANCOVAs of partition vs. brain volume scaling, as well as growth curve comparisons, do not support several hypotheses consistent with developmental constraints: brain partition growth significantly differs between species, or between developing vs. adult marsupials. Partition growth appears independent of adult brain volume, with no discernable growth spurts/lags relatable to internal structural change. Rather, adult proportion differences appear to arise through growth rate/duration heterochrony. Substantial phylogenetic signal in adult brain partitions scaling with brain volume also counters expectations of development-mediated partition scaling conservatism. However, the scaling of olfactory bulb growth is markedly irregular, consistent with suggestions that it is less constrained. The very regular partition growth curves suggest intraspecific developmental rigidity. We speculate that a rigid, possibly neuromer-model-like early molecular program might be responsible both for regular growth curves within species and impressions of a link between neurogenesis and partition evolution.
format	article
author	Alison Carlisle Lynne Selwood Lyn A. Hinds Norman Saunders Mark Habgood Karine Mardon Vera Weisbecker
author_facet	Alison Carlisle Lynne Selwood Lyn A. Hinds Norman Saunders Mark Habgood Karine Mardon Vera Weisbecker
author_sort	Alison Carlisle
title	Testing hypotheses of developmental constraints on mammalian brain partition evolution, using marsupials
title_short	Testing hypotheses of developmental constraints on mammalian brain partition evolution, using marsupials
title_full	Testing hypotheses of developmental constraints on mammalian brain partition evolution, using marsupials
title_fullStr	Testing hypotheses of developmental constraints on mammalian brain partition evolution, using marsupials
title_full_unstemmed	Testing hypotheses of developmental constraints on mammalian brain partition evolution, using marsupials
title_sort	testing hypotheses of developmental constraints on mammalian brain partition evolution, using marsupials
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/1c1c2afdf1e34f749d418eaf38c99573
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_version_	1718384888314331136

Testing hypotheses of developmental constraints on mammalian brain partition evolution, using marsupials

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