Impact of chronic respiratory diseases on re-intubation rate in critically ill patients: a cohort study

Abstract Chronic respiratory diseases’ (CRDs) impact on re-intubation rate remains unclear. We investigated the association between these factors in mechanically ventilated patients. Data were extracted from the freely available online Medical Information Mart for Intensive Care III database. CRDs w...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Yanfei Shen, Weizhe Ru, Xinmei Huang, Shangzhong Chen, Jing Yan, Zhouxin Yang, Guolong Cai
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/1c1c3cfb788c4a6492bc48d38c11e640
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:1c1c3cfb788c4a6492bc48d38c11e640
record_format	dspace
spelling	oai:doaj.org-article:1c1c3cfb788c4a6492bc48d38c11e6402021-12-02T15:27:06ZImpact of chronic respiratory diseases on re-intubation rate in critically ill patients: a cohort study10.1038/s41598-021-88007-y2045-2322https://doaj.org/article/1c1c3cfb788c4a6492bc48d38c11e6402021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-88007-yhttps://doaj.org/toc/2045-2322Abstract Chronic respiratory diseases’ (CRDs) impact on re-intubation rate remains unclear. We investigated the association between these factors in mechanically ventilated patients. Data were extracted from the freely available online Medical Information Mart for Intensive Care III database. CRDs were defined according to ICD-9 codes. Generalised linear regression and propensity score matching were performed. Of 13,132 patients, 7.9% required re-intubation. Patients with chronic obstructive pulmonary disease (COPD) had higher re-intubation (OR 2.48, 95% CI 1.83–3.33) and mortality rates (OR 1.64, 95% CI 1.15–2.34) than those without. Patients with asthma had a lower mortality rate (OR 0.63, 95% CI 0.43–0.92) but a similar re-intubation rate to those of patients without. These findings remained stable after propensity score matching and bootstrapping analysis. The association of COPD with re-intubation was significantly stronger in patients with high oxygen-partial pressure (PaO2) or mild disease severity but was independent of carbon dioxide partial pressure. Corticosteroid use was associated with increased re-intubation rates in subgroups without CRDs (OR 1.77–1.99, p < 0.001) but not in subgroups with CRDs. COPD patients with high post-extubation PaO2 or mild disease severity should be carefully monitored as they have higher re-intubation and mortality rates.Yanfei ShenWeizhe RuXinmei HuangShangzhong ChenJing YanZhouxin YangGuolong CaiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yanfei Shen Weizhe Ru Xinmei Huang Shangzhong Chen Jing Yan Zhouxin Yang Guolong Cai Impact of chronic respiratory diseases on re-intubation rate in critically ill patients: a cohort study
description	Abstract Chronic respiratory diseases’ (CRDs) impact on re-intubation rate remains unclear. We investigated the association between these factors in mechanically ventilated patients. Data were extracted from the freely available online Medical Information Mart for Intensive Care III database. CRDs were defined according to ICD-9 codes. Generalised linear regression and propensity score matching were performed. Of 13,132 patients, 7.9% required re-intubation. Patients with chronic obstructive pulmonary disease (COPD) had higher re-intubation (OR 2.48, 95% CI 1.83–3.33) and mortality rates (OR 1.64, 95% CI 1.15–2.34) than those without. Patients with asthma had a lower mortality rate (OR 0.63, 95% CI 0.43–0.92) but a similar re-intubation rate to those of patients without. These findings remained stable after propensity score matching and bootstrapping analysis. The association of COPD with re-intubation was significantly stronger in patients with high oxygen-partial pressure (PaO2) or mild disease severity but was independent of carbon dioxide partial pressure. Corticosteroid use was associated with increased re-intubation rates in subgroups without CRDs (OR 1.77–1.99, p < 0.001) but not in subgroups with CRDs. COPD patients with high post-extubation PaO2 or mild disease severity should be carefully monitored as they have higher re-intubation and mortality rates.
format	article
author	Yanfei Shen Weizhe Ru Xinmei Huang Shangzhong Chen Jing Yan Zhouxin Yang Guolong Cai
author_facet	Yanfei Shen Weizhe Ru Xinmei Huang Shangzhong Chen Jing Yan Zhouxin Yang Guolong Cai
author_sort	Yanfei Shen
title	Impact of chronic respiratory diseases on re-intubation rate in critically ill patients: a cohort study
title_short	Impact of chronic respiratory diseases on re-intubation rate in critically ill patients: a cohort study
title_full	Impact of chronic respiratory diseases on re-intubation rate in critically ill patients: a cohort study
title_fullStr	Impact of chronic respiratory diseases on re-intubation rate in critically ill patients: a cohort study
title_full_unstemmed	Impact of chronic respiratory diseases on re-intubation rate in critically ill patients: a cohort study
title_sort	impact of chronic respiratory diseases on re-intubation rate in critically ill patients: a cohort study
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/1c1c3cfb788c4a6492bc48d38c11e640
work_keys_str_mv	AT yanfeishen impactofchronicrespiratorydiseasesonreintubationrateincriticallyillpatientsacohortstudy AT weizheru impactofchronicrespiratorydiseasesonreintubationrateincriticallyillpatientsacohortstudy AT xinmeihuang impactofchronicrespiratorydiseasesonreintubationrateincriticallyillpatientsacohortstudy AT shangzhongchen impactofchronicrespiratorydiseasesonreintubationrateincriticallyillpatientsacohortstudy AT jingyan impactofchronicrespiratorydiseasesonreintubationrateincriticallyillpatientsacohortstudy AT zhouxinyang impactofchronicrespiratorydiseasesonreintubationrateincriticallyillpatientsacohortstudy AT guolongcai impactofchronicrespiratorydiseasesonreintubationrateincriticallyillpatientsacohortstudy
_version_	1718387189369274368

Impact of chronic respiratory diseases on re-intubation rate in critically ill patients: a cohort study

Ejemplares similares