Costimulation of type-2 innate lymphoid cells by GITR promotes effector function and ameliorates type 2 diabetes

Type-2 innate lymphoid cells (ILC2s) are an immune population secreting Th2 cytokines playing a role in the regulation of adipose metabolic homeostasis. Here the authors show that engagement of GITR, a member of the TNF superfamily, in activated ILC2s is protective against insulin resistance in both...

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Autores principales:	Lauriane Galle-Treger, Ishwarya Sankaranarayanan, Benjamin P. Hurrell, Emily Howard, Richard Lo, Hadi Maazi, Gavin Lewis, Homayon Banie, Alan L. Epstein, Peisheng Hu, Virender K. Rehan, Frank D. Gilliland, Hooman Allayee, Pejman Soroosh, Arlene H. Sharpe, Omid Akbari
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/1c23f79b445447f9ae0cd84879992375
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spelling	oai:doaj.org-article:1c23f79b445447f9ae0cd848799923752021-12-02T17:32:23ZCostimulation of type-2 innate lymphoid cells by GITR promotes effector function and ameliorates type 2 diabetes10.1038/s41467-019-08449-x2041-1723https://doaj.org/article/1c23f79b445447f9ae0cd848799923752019-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-08449-xhttps://doaj.org/toc/2041-1723Type-2 innate lymphoid cells (ILC2s) are an immune population secreting Th2 cytokines playing a role in the regulation of adipose metabolic homeostasis. Here the authors show that engagement of GITR, a member of the TNF superfamily, in activated ILC2s is protective against insulin resistance in both a preventive and a therapeutic manner in the context of obesity.Lauriane Galle-TregerIshwarya SankaranarayananBenjamin P. HurrellEmily HowardRichard LoHadi MaaziGavin LewisHomayon BanieAlan L. EpsteinPeisheng HuVirender K. RehanFrank D. GillilandHooman AllayeePejman SorooshArlene H. SharpeOmid AkbariNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Lauriane Galle-Treger Ishwarya Sankaranarayanan Benjamin P. Hurrell Emily Howard Richard Lo Hadi Maazi Gavin Lewis Homayon Banie Alan L. Epstein Peisheng Hu Virender K. Rehan Frank D. Gilliland Hooman Allayee Pejman Soroosh Arlene H. Sharpe Omid Akbari Costimulation of type-2 innate lymphoid cells by GITR promotes effector function and ameliorates type 2 diabetes
description	Type-2 innate lymphoid cells (ILC2s) are an immune population secreting Th2 cytokines playing a role in the regulation of adipose metabolic homeostasis. Here the authors show that engagement of GITR, a member of the TNF superfamily, in activated ILC2s is protective against insulin resistance in both a preventive and a therapeutic manner in the context of obesity.
format	article
author	Lauriane Galle-Treger Ishwarya Sankaranarayanan Benjamin P. Hurrell Emily Howard Richard Lo Hadi Maazi Gavin Lewis Homayon Banie Alan L. Epstein Peisheng Hu Virender K. Rehan Frank D. Gilliland Hooman Allayee Pejman Soroosh Arlene H. Sharpe Omid Akbari
author_facet	Lauriane Galle-Treger Ishwarya Sankaranarayanan Benjamin P. Hurrell Emily Howard Richard Lo Hadi Maazi Gavin Lewis Homayon Banie Alan L. Epstein Peisheng Hu Virender K. Rehan Frank D. Gilliland Hooman Allayee Pejman Soroosh Arlene H. Sharpe Omid Akbari
author_sort	Lauriane Galle-Treger
title	Costimulation of type-2 innate lymphoid cells by GITR promotes effector function and ameliorates type 2 diabetes
title_short	Costimulation of type-2 innate lymphoid cells by GITR promotes effector function and ameliorates type 2 diabetes
title_full	Costimulation of type-2 innate lymphoid cells by GITR promotes effector function and ameliorates type 2 diabetes
title_fullStr	Costimulation of type-2 innate lymphoid cells by GITR promotes effector function and ameliorates type 2 diabetes
title_full_unstemmed	Costimulation of type-2 innate lymphoid cells by GITR promotes effector function and ameliorates type 2 diabetes
title_sort	costimulation of type-2 innate lymphoid cells by gitr promotes effector function and ameliorates type 2 diabetes
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/1c23f79b445447f9ae0cd84879992375
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Costimulation of type-2 innate lymphoid cells by GITR promotes effector function and ameliorates type 2 diabetes

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