Bioinformatic Analysis of Prognostic Value, Genetic Interaction, and Immune Infiltration of Chromobox Family Proteins in Breast Cancer

Guochao Mao, Yi Zheng, Shuai Lin, Li Ma, Zhangjian Zhou, Shuqun Zhang Department of Oncology, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, 710000, People’s Republic of ChinaCorrespondence: Guochao MaoDepartment of Oncology, The Second Affiliated Hospital of Xi’an Jiao...

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Autores principales:	Mao G, Zheng Y, Lin S, Ma L, Zhou Z, Zhang S
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	comprehensive analysis chromobox family members breast cancer prognosis genetic interaction immune infiltration Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/1c2426c723ae4ce69bd344468f3623b0
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spelling	oai:doaj.org-article:1c2426c723ae4ce69bd344468f3623b02021-11-30T18:50:36ZBioinformatic Analysis of Prognostic Value, Genetic Interaction, and Immune Infiltration of Chromobox Family Proteins in Breast Cancer1178-7074https://doaj.org/article/1c2426c723ae4ce69bd344468f3623b02021-12-01T00:00:00Zhttps://www.dovepress.com/bioinformatic-analysis-of-prognostic-value-genetic-interaction-and-imm-peer-reviewed-fulltext-article-IJGMhttps://doaj.org/toc/1178-7074Guochao Mao, Yi Zheng, Shuai Lin, Li Ma, Zhangjian Zhou, Shuqun Zhang Department of Oncology, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, 710000, People’s Republic of ChinaCorrespondence: Guochao MaoDepartment of Oncology, The Second Affiliated Hospital of Xi’an Jiaotong University, No. 157 Xiwu Road, Xi’an, Shaanxi, 710000, People’s Republic of ChinaTel +8615991381508Fax +8602987679512Email gchmao@163.comIntroduction: Breast cancer (BC) has become the malignant tumor with the highest incidence worldwide. As a critical components of epigenetic regulation complexes, chromobox (CBX) family members inhibit the transcription of target genes through chromatin modification, leading to the progression of various human diseases and cancers. So far, little is known about the role of different CBX members in BC, especially their association with immune cells.Methods: We conducted the analysis of differential expression of CBXs using Oncomine and GEPIA, prognostic value of CBXs using GEPIA and Kaplan-Meier, genetic interaction of CBXs using cBioPortal and GeneMANIA, and immune cell infiltration of CBXs in BC patients using TIMER.Results: The CBX2/3/4/8 expression levels were increased significantly, while the CBX6/7 expression levels were decreased. We found that CBX3 was significantly correlated with clinicopathological staging and short DFS in BC patients. High CBX3/5 expression was correlated with short OS in BC patients, while high expression of CBX4 was correlated with long OS in BC patients. In addition, the functions of CBXs family members mainly focus on methylated histone residue binding and chromatin organization. The CBXs expressions were closely related to the infiltration level of a variety of immune cells, including CD4/8+ T cells, B cells, neutrophils, macrophages and dendritic cells in BC cancers. The correlation between CBXs and immune cell infiltration was more common in Luminal BC than in Basal and Her-2 type.Conclusion: This study may provide a new understanding for selection of molecular typing, therapeutic and prognostic biomarkers of CBX family in BC.Keywords: comprehensive analysis, chromobox family members, breast cancer, prognosis, genetic interaction, immune infiltrationMao GZheng YLin SMa LZhou ZZhang SDove Medical Pressarticlecomprehensive analysischromobox family membersbreast cancerprognosisgenetic interactionimmune infiltrationMedicine (General)R5-920ENInternational Journal of General Medicine, Vol Volume 14, Pp 9181-9191 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	comprehensive analysis chromobox family members breast cancer prognosis genetic interaction immune infiltration Medicine (General) R5-920
spellingShingle	comprehensive analysis chromobox family members breast cancer prognosis genetic interaction immune infiltration Medicine (General) R5-920 Mao G Zheng Y Lin S Ma L Zhou Z Zhang S Bioinformatic Analysis of Prognostic Value, Genetic Interaction, and Immune Infiltration of Chromobox Family Proteins in Breast Cancer
description	Guochao Mao, Yi Zheng, Shuai Lin, Li Ma, Zhangjian Zhou, Shuqun Zhang Department of Oncology, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, 710000, People’s Republic of ChinaCorrespondence: Guochao MaoDepartment of Oncology, The Second Affiliated Hospital of Xi’an Jiaotong University, No. 157 Xiwu Road, Xi’an, Shaanxi, 710000, People’s Republic of ChinaTel +8615991381508Fax +8602987679512Email gchmao@163.comIntroduction: Breast cancer (BC) has become the malignant tumor with the highest incidence worldwide. As a critical components of epigenetic regulation complexes, chromobox (CBX) family members inhibit the transcription of target genes through chromatin modification, leading to the progression of various human diseases and cancers. So far, little is known about the role of different CBX members in BC, especially their association with immune cells.Methods: We conducted the analysis of differential expression of CBXs using Oncomine and GEPIA, prognostic value of CBXs using GEPIA and Kaplan-Meier, genetic interaction of CBXs using cBioPortal and GeneMANIA, and immune cell infiltration of CBXs in BC patients using TIMER.Results: The CBX2/3/4/8 expression levels were increased significantly, while the CBX6/7 expression levels were decreased. We found that CBX3 was significantly correlated with clinicopathological staging and short DFS in BC patients. High CBX3/5 expression was correlated with short OS in BC patients, while high expression of CBX4 was correlated with long OS in BC patients. In addition, the functions of CBXs family members mainly focus on methylated histone residue binding and chromatin organization. The CBXs expressions were closely related to the infiltration level of a variety of immune cells, including CD4/8+ T cells, B cells, neutrophils, macrophages and dendritic cells in BC cancers. The correlation between CBXs and immune cell infiltration was more common in Luminal BC than in Basal and Her-2 type.Conclusion: This study may provide a new understanding for selection of molecular typing, therapeutic and prognostic biomarkers of CBX family in BC.Keywords: comprehensive analysis, chromobox family members, breast cancer, prognosis, genetic interaction, immune infiltration
format	article
author	Mao G Zheng Y Lin S Ma L Zhou Z Zhang S
author_facet	Mao G Zheng Y Lin S Ma L Zhou Z Zhang S
author_sort	Mao G
title	Bioinformatic Analysis of Prognostic Value, Genetic Interaction, and Immune Infiltration of Chromobox Family Proteins in Breast Cancer
title_short	Bioinformatic Analysis of Prognostic Value, Genetic Interaction, and Immune Infiltration of Chromobox Family Proteins in Breast Cancer
title_full	Bioinformatic Analysis of Prognostic Value, Genetic Interaction, and Immune Infiltration of Chromobox Family Proteins in Breast Cancer
title_fullStr	Bioinformatic Analysis of Prognostic Value, Genetic Interaction, and Immune Infiltration of Chromobox Family Proteins in Breast Cancer
title_full_unstemmed	Bioinformatic Analysis of Prognostic Value, Genetic Interaction, and Immune Infiltration of Chromobox Family Proteins in Breast Cancer
title_sort	bioinformatic analysis of prognostic value, genetic interaction, and immune infiltration of chromobox family proteins in breast cancer
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/1c2426c723ae4ce69bd344468f3623b0
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Bioinformatic Analysis of Prognostic Value, Genetic Interaction, and Immune Infiltration of Chromobox Family Proteins in Breast Cancer

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