Plasma cell survival in the absence of B cell memory

The long-term maintenance of antibody-secreting plasma cells and the requirement for memory B cells are unclear. Here, the authors show that plasma cells and the antibodies secreted are long-lived and maintained over a decade in the absence of memory B cells in non-human primates.

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Detalles Bibliográficos
Autores principales: Erika Hammarlund, Archana Thomas, Ian J. Amanna, Lindsay A. Holden, Ov D. Slayden, Byung Park, Lina Gao, Mark K. Slifka
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/1c247d33ca304c67924a5f0adaff21c2
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Descripción
Sumario:The long-term maintenance of antibody-secreting plasma cells and the requirement for memory B cells are unclear. Here, the authors show that plasma cells and the antibodies secreted are long-lived and maintained over a decade in the absence of memory B cells in non-human primates.