Uncovering Virus-Virus Interactions by Unifying Approaches and Harnessing High-Throughput Tools

ABSTRACT Virus-host interactions have received much attention in virology. Virus-virus interactions can occur when >1 virus infects a host and can be deemed social when one virus affects the fitness of another virus, as in the well-known case of superinfection exclusion. Coinfection and subsequen...

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Autor principal:	Samuel L. Díaz-Muñoz
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2019
Materias:	coinfection ecology evolution reassortment sociovirology Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/1c25a07388324366baecfbee3e43d4c1
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spelling	oai:doaj.org-article:1c25a07388324366baecfbee3e43d4c12021-12-02T18:44:38ZUncovering Virus-Virus Interactions by Unifying Approaches and Harnessing High-Throughput Tools10.1128/mSystems.00121-192379-5077https://doaj.org/article/1c25a07388324366baecfbee3e43d4c12019-06-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mSystems.00121-19https://doaj.org/toc/2379-5077ABSTRACT Virus-host interactions have received much attention in virology. Virus-virus interactions can occur when >1 virus infects a host and can be deemed social when one virus affects the fitness of another virus, as in the well-known case of superinfection exclusion. Coinfection and subsequent social interactions can change viral pathogenicity, host range, and genetic composition, with implications for human health and viral evolution. I propose that this field can be advanced by bringing new perspectives into virology (e.g., social evolution theory) and uniting disciplinary divides within virology (classical, host-focused, and ecoevolutionary). The development of novel high-throughput tools that meld molecular and evolutionary approaches can harness viral diversity as an experimental asset to understand complex viral social interactions. A greater knowledge of virus-virus interactions will lead to the reformulation of basic concepts of virology and advances in applied virology, with new treatments that harness interactions between viruses to fight viral and bacterial infections.Samuel L. Díaz-MuñozAmerican Society for MicrobiologyarticlecoinfectionecologyevolutionreassortmentsociovirologyMicrobiologyQR1-502ENmSystems, Vol 4, Iss 3 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	coinfection ecology evolution reassortment sociovirology Microbiology QR1-502
spellingShingle	coinfection ecology evolution reassortment sociovirology Microbiology QR1-502 Samuel L. Díaz-Muñoz Uncovering Virus-Virus Interactions by Unifying Approaches and Harnessing High-Throughput Tools
description	ABSTRACT Virus-host interactions have received much attention in virology. Virus-virus interactions can occur when >1 virus infects a host and can be deemed social when one virus affects the fitness of another virus, as in the well-known case of superinfection exclusion. Coinfection and subsequent social interactions can change viral pathogenicity, host range, and genetic composition, with implications for human health and viral evolution. I propose that this field can be advanced by bringing new perspectives into virology (e.g., social evolution theory) and uniting disciplinary divides within virology (classical, host-focused, and ecoevolutionary). The development of novel high-throughput tools that meld molecular and evolutionary approaches can harness viral diversity as an experimental asset to understand complex viral social interactions. A greater knowledge of virus-virus interactions will lead to the reformulation of basic concepts of virology and advances in applied virology, with new treatments that harness interactions between viruses to fight viral and bacterial infections.
format	article
author	Samuel L. Díaz-Muñoz
author_facet	Samuel L. Díaz-Muñoz
author_sort	Samuel L. Díaz-Muñoz
title	Uncovering Virus-Virus Interactions by Unifying Approaches and Harnessing High-Throughput Tools
title_short	Uncovering Virus-Virus Interactions by Unifying Approaches and Harnessing High-Throughput Tools
title_full	Uncovering Virus-Virus Interactions by Unifying Approaches and Harnessing High-Throughput Tools
title_fullStr	Uncovering Virus-Virus Interactions by Unifying Approaches and Harnessing High-Throughput Tools
title_full_unstemmed	Uncovering Virus-Virus Interactions by Unifying Approaches and Harnessing High-Throughput Tools
title_sort	uncovering virus-virus interactions by unifying approaches and harnessing high-throughput tools
publisher	American Society for Microbiology
publishDate	2019
url	https://doaj.org/article/1c25a07388324366baecfbee3e43d4c1
work_keys_str_mv	AT samuelldiazmunoz uncoveringvirusvirusinteractionsbyunifyingapproachesandharnessinghighthroughputtools
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Uncovering Virus-Virus Interactions by Unifying Approaches and Harnessing High-Throughput Tools

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