SLC12A8 plays a key role in bladder cancer progression and EMT

Bladder cancer is the most common malignant tumor of the urinary system. The intention of the present research is to explore the prognostic value and biological function of solute carrier family 12 member 8 (SLC12A8) in bladder cancer. The analysis based on the TCGA and ONCOMINE database revealed th...

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Autores principales:	Li Shun-Lai, Li Zheng-Feng, Cao Qing-Wei, Wang Wen-Zhen
Formato:	article
Lenguaje:	EN
Publicado:	De Gruyter 2020
Materias:	slc12a8 bladder cancer upregulation emt prognosis Medicine R
Acceso en línea:	https://doaj.org/article/1c25f74807a94bdcb5a855fcf8a57e43
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spelling	oai:doaj.org-article:1c25f74807a94bdcb5a855fcf8a57e432021-12-05T14:10:53ZSLC12A8 plays a key role in bladder cancer progression and EMT2391-546310.1515/med-2021-0013https://doaj.org/article/1c25f74807a94bdcb5a855fcf8a57e432020-12-01T00:00:00Zhttps://doi.org/10.1515/med-2021-0013https://doaj.org/toc/2391-5463Bladder cancer is the most common malignant tumor of the urinary system. The intention of the present research is to explore the prognostic value and biological function of solute carrier family 12 member 8 (SLC12A8) in bladder cancer. The analysis based on the TCGA and ONCOMINE database revealed that the expression of SLC12A8 in bladder cancer was notably increased compared with the normal group. SLC12A8 expression was notably correlated with the age, pathological stage, T-stage, and lymph node metastasis of bladder cancer patients. Moreover, the patients’ overall survival was notably shorter in the high SLC12A8 group. Compared with the control, SLC12A8 upregulation enhanced the proliferative, invasive, and migratory capacities of bladder cancer cells and promoted the expression of epithelial–mesenchymal transition (EMT) protein markers including β-catenin, vimentin, snail, and slug, while reduced the expression of E-cadherin. In the case of downregulated SLC12A8 expression, the proliferative, invasive, and migratory capacities of bladder cancer cells and the expression of EMT protein markers presented the opposite trend. This study demonstrated that SLC12A8 was highly correlated with oncogenesis and progression of bladder cancer, indicating that SLC12A8 may be a meaningful biomarker for initial diagnosis and early treatment of bladder cancer.Li Shun-LaiLi Zheng-FengCao Qing-WeiWang Wen-ZhenDe Gruyterarticleslc12a8bladder cancerupregulationemtprognosisMedicineRENOpen Medicine, Vol 16, Iss 1, Pp 058-067 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	slc12a8 bladder cancer upregulation emt prognosis Medicine R
spellingShingle	slc12a8 bladder cancer upregulation emt prognosis Medicine R Li Shun-Lai Li Zheng-Feng Cao Qing-Wei Wang Wen-Zhen SLC12A8 plays a key role in bladder cancer progression and EMT
description	Bladder cancer is the most common malignant tumor of the urinary system. The intention of the present research is to explore the prognostic value and biological function of solute carrier family 12 member 8 (SLC12A8) in bladder cancer. The analysis based on the TCGA and ONCOMINE database revealed that the expression of SLC12A8 in bladder cancer was notably increased compared with the normal group. SLC12A8 expression was notably correlated with the age, pathological stage, T-stage, and lymph node metastasis of bladder cancer patients. Moreover, the patients’ overall survival was notably shorter in the high SLC12A8 group. Compared with the control, SLC12A8 upregulation enhanced the proliferative, invasive, and migratory capacities of bladder cancer cells and promoted the expression of epithelial–mesenchymal transition (EMT) protein markers including β-catenin, vimentin, snail, and slug, while reduced the expression of E-cadherin. In the case of downregulated SLC12A8 expression, the proliferative, invasive, and migratory capacities of bladder cancer cells and the expression of EMT protein markers presented the opposite trend. This study demonstrated that SLC12A8 was highly correlated with oncogenesis and progression of bladder cancer, indicating that SLC12A8 may be a meaningful biomarker for initial diagnosis and early treatment of bladder cancer.
format	article
author	Li Shun-Lai Li Zheng-Feng Cao Qing-Wei Wang Wen-Zhen
author_facet	Li Shun-Lai Li Zheng-Feng Cao Qing-Wei Wang Wen-Zhen
author_sort	Li Shun-Lai
title	SLC12A8 plays a key role in bladder cancer progression and EMT
title_short	SLC12A8 plays a key role in bladder cancer progression and EMT
title_full	SLC12A8 plays a key role in bladder cancer progression and EMT
title_fullStr	SLC12A8 plays a key role in bladder cancer progression and EMT
title_full_unstemmed	SLC12A8 plays a key role in bladder cancer progression and EMT
title_sort	slc12a8 plays a key role in bladder cancer progression and emt
publisher	De Gruyter
publishDate	2020
url	https://doaj.org/article/1c25f74807a94bdcb5a855fcf8a57e43
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_version_	1718371587562930176

SLC12A8 plays a key role in bladder cancer progression and EMT

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