Can We Corroborate Peripapillary RNFL Analysis with Macular GCIPL Analysis? Our 2-Year Experience at a Single-Centre Tertiary Healthcare Hospital Using Two OCT Machines and a Review of Literature

Sangeeta Abrol,1 Sukriti Gupta,1 Mayuresh Naik,2 Siddharth Agarwal3 1Department of Ophthalmology, V.M.M.C & Safdarjung Hospital, New Delhi 110029, India; 2Department of Ophthalmology, H.I.M.S.R & H.A.H. Centenary Hospital, New Delhi 110062, India; 3Department of Research, Mayo Clinic...

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Autores principales:	Abrol S, Gupta S, Naik M, Agarwal S
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	rnfl ; gcc ; perimetric glaucoma ; pre-perimetric glaucoma . Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/1c25f9fb38ed48e199e4935b531a6746
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spelling	oai:doaj.org-article:1c25f9fb38ed48e199e4935b531a67462021-12-02T10:45:08ZCan We Corroborate Peripapillary RNFL Analysis with Macular GCIPL Analysis? Our 2-Year Experience at a Single-Centre Tertiary Healthcare Hospital Using Two OCT Machines and a Review of Literature1177-5483https://doaj.org/article/1c25f9fb38ed48e199e4935b531a67462020-11-01T00:00:00Zhttps://www.dovepress.com/can-we-corroborate-peripapillary-rnfl-analysis-with-macular-gcipl-anal-peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Sangeeta Abrol,1 Sukriti Gupta,1 Mayuresh Naik,2 Siddharth Agarwal3 1Department of Ophthalmology, V.M.M.C & Safdarjung Hospital, New Delhi 110029, India; 2Department of Ophthalmology, H.I.M.S.R & H.A.H. Centenary Hospital, New Delhi 110062, India; 3Department of Research, Mayo Clinic, Rochester, MN, USACorrespondence: Mayuresh NaikDepartment of Ophthalmology, H.I.M.S.R & H.A.H. Centenary Hospital, Room No. 3 of Eye OPD, 1st Floor of OPD Building, Near GK-2, Alaknanda, New Delhi 110062, IndiaTel +91-8287344576Email mayureshpnaik@gmail.comPurpose: To determine whether macular volume and macular GCA measurements in patients are comparable to their RNFL thickness parameters.Materials and Methods: The cross-sectional, observational study was conducted on 1380 eyes with 460 each, into three groups. Group I: patients with healthy eyes. Group II: patients diagnosed as pre-perimetric glaucoma. Group III: patients with diagnosed perimetric glaucoma. After patients were selected on the basis of inclusion and exclusion criteria, baseline standard ophthalmic examination was done by the same operator under the same settings, including SD-OCT using both the Spectralis SD-OCT and the Cirrus SD-OCT as elaborated below.Statistical Analysis: Data were checked for normality before statistical analysis using Shapiro–Wilk test. Normally distributed continuous variables were compared using ANOVA. For all statistical tests, a p < 0.05 was taken to indicate a significant difference. Receiver operating characteristic (ROC) curves were used to define the ability RNFL and GCC parameters to distinguish perimetric and preperimetric glaucomatous eyes from control eyes.Results: There was a statistically significant difference in the average, superior, inferior RNFL thickness and average, superior, inferior GCIPL thickness between Group I and Group II (p< 0.001), between Group I and Group III (p< 0.001) and also between Group II and Group III (p< 0.001). The statistical significance was also reflected in their AUROCs.Conclusion: Mean, superior, inferior GCIPL thickness along with macular volume analysis can substantiate RNFL analysis for diagnosis, serial monitoring and follow-up of glaucoma patients and suspects.Keywords: RNFL, GCC, perimetric glaucoma, pre-perimetric glaucomaAbrol SGupta SNaik MAgarwal SDove Medical Pressarticlernfl ; gcc ; perimetric glaucoma ; pre-perimetric glaucoma .OphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 14, Pp 3763-3774 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	rnfl ; gcc ; perimetric glaucoma ; pre-perimetric glaucoma . Ophthalmology RE1-994
spellingShingle	rnfl ; gcc ; perimetric glaucoma ; pre-perimetric glaucoma . Ophthalmology RE1-994 Abrol S Gupta S Naik M Agarwal S Can We Corroborate Peripapillary RNFL Analysis with Macular GCIPL Analysis? Our 2-Year Experience at a Single-Centre Tertiary Healthcare Hospital Using Two OCT Machines and a Review of Literature
description	Sangeeta Abrol,1 Sukriti Gupta,1 Mayuresh Naik,2 Siddharth Agarwal3 1Department of Ophthalmology, V.M.M.C & Safdarjung Hospital, New Delhi 110029, India; 2Department of Ophthalmology, H.I.M.S.R & H.A.H. Centenary Hospital, New Delhi 110062, India; 3Department of Research, Mayo Clinic, Rochester, MN, USACorrespondence: Mayuresh NaikDepartment of Ophthalmology, H.I.M.S.R & H.A.H. Centenary Hospital, Room No. 3 of Eye OPD, 1st Floor of OPD Building, Near GK-2, Alaknanda, New Delhi 110062, IndiaTel +91-8287344576Email mayureshpnaik@gmail.comPurpose: To determine whether macular volume and macular GCA measurements in patients are comparable to their RNFL thickness parameters.Materials and Methods: The cross-sectional, observational study was conducted on 1380 eyes with 460 each, into three groups. Group I: patients with healthy eyes. Group II: patients diagnosed as pre-perimetric glaucoma. Group III: patients with diagnosed perimetric glaucoma. After patients were selected on the basis of inclusion and exclusion criteria, baseline standard ophthalmic examination was done by the same operator under the same settings, including SD-OCT using both the Spectralis SD-OCT and the Cirrus SD-OCT as elaborated below.Statistical Analysis: Data were checked for normality before statistical analysis using Shapiro–Wilk test. Normally distributed continuous variables were compared using ANOVA. For all statistical tests, a p < 0.05 was taken to indicate a significant difference. Receiver operating characteristic (ROC) curves were used to define the ability RNFL and GCC parameters to distinguish perimetric and preperimetric glaucomatous eyes from control eyes.Results: There was a statistically significant difference in the average, superior, inferior RNFL thickness and average, superior, inferior GCIPL thickness between Group I and Group II (p< 0.001), between Group I and Group III (p< 0.001) and also between Group II and Group III (p< 0.001). The statistical significance was also reflected in their AUROCs.Conclusion: Mean, superior, inferior GCIPL thickness along with macular volume analysis can substantiate RNFL analysis for diagnosis, serial monitoring and follow-up of glaucoma patients and suspects.Keywords: RNFL, GCC, perimetric glaucoma, pre-perimetric glaucoma
format	article
author	Abrol S Gupta S Naik M Agarwal S
author_facet	Abrol S Gupta S Naik M Agarwal S
author_sort	Abrol S
title	Can We Corroborate Peripapillary RNFL Analysis with Macular GCIPL Analysis? Our 2-Year Experience at a Single-Centre Tertiary Healthcare Hospital Using Two OCT Machines and a Review of Literature
title_short	Can We Corroborate Peripapillary RNFL Analysis with Macular GCIPL Analysis? Our 2-Year Experience at a Single-Centre Tertiary Healthcare Hospital Using Two OCT Machines and a Review of Literature
title_full	Can We Corroborate Peripapillary RNFL Analysis with Macular GCIPL Analysis? Our 2-Year Experience at a Single-Centre Tertiary Healthcare Hospital Using Two OCT Machines and a Review of Literature
title_fullStr	Can We Corroborate Peripapillary RNFL Analysis with Macular GCIPL Analysis? Our 2-Year Experience at a Single-Centre Tertiary Healthcare Hospital Using Two OCT Machines and a Review of Literature
title_full_unstemmed	Can We Corroborate Peripapillary RNFL Analysis with Macular GCIPL Analysis? Our 2-Year Experience at a Single-Centre Tertiary Healthcare Hospital Using Two OCT Machines and a Review of Literature
title_sort	can we corroborate peripapillary rnfl analysis with macular gcipl analysis? our 2-year experience at a single-centre tertiary healthcare hospital using two oct machines and a review of literature
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/1c25f9fb38ed48e199e4935b531a6746
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Can We Corroborate Peripapillary RNFL Analysis with Macular GCIPL Analysis? Our 2-Year Experience at a Single-Centre Tertiary Healthcare Hospital Using Two OCT Machines and a Review of Literature

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