Effect of 3 years of treatment with a dorzolamide/timolol (1%/0.5%) combination on intraocular pressure

Effect of 3 years of treatment with a dorzolamide/timolol (1%/0.5%) combination on intraocular pressure

Sakurako Takeda,1,2 Tatsuya Mimura,1 Masao Matsubara1,2 1Department of Ophthalmology, Tokyo Women’s Medical University Medical Center East, Tokyo, Japan; 2Department of Ophthalmology, Nippori Clinic, Medical Center East, Tokyo Women’s Medical University, Tokyo, Japan Purpose:...

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Autores principales: Takeda S, Mimura T, Matsubara M
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Publicado: Dove Medical Press 2014
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Ophthalmology
RE1-994
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spelling oai:doaj.org-article:1c2616e1d1fe4efc9e2694525bd133952021-12-02T09:31:19ZEffect of 3 years of treatment with a dorzolamide/timolol (1%/0.5%) combination on intraocular pressure1177-5483https://doaj.org/article/1c2616e1d1fe4efc9e2694525bd133952014-09-01T00:00:00Zhttp://www.dovepress.com/effect-of-3nbspyears-of-treatment-with-a-dorzolamidetimolol-105-combin-peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483 Sakurako Takeda,1,2 Tatsuya Mimura,1 Masao Matsubara1,2 1Department of Ophthalmology, Tokyo Women’s Medical University Medical Center East, Tokyo, Japan; 2Department of Ophthalmology, Nippori Clinic, Medical Center East, Tokyo Women’s Medical University, Tokyo, Japan Purpose: We aimed to evaluate the effect on the intraocular pressure (IOP) of a dorzolamide/timolol (1%/0.5%) fixed combination (DTFC) ophthalmic agent for 3 years.Participants: A total of 19 consecutive patients who had previously been treated with monotherapy or any combination of a beta-blocker, carbonic anhydrase inhibitor, or prostaglandin analog, for primary open-angle glaucoma (POAG) (n=5) or normal tension glaucoma (N=14) were enrolled.Methods: Patients were switched to DTFC from their prior glaucoma therapy. The IOP was measured at intervals of 4–6 weeks for 3 years. Treatment failure was defined as an increase of IOP by ≥10% from baseline after switching to DTFC.Results: The average IOP decreased significantly from 14.1±2.9 mmHg at baseline to 12.2±2.2, 11.8±2.4, 12.1±2.5, 11.6±1.8, and 12.1±2.7 mmHg at 3, 6, 12, 24, and 36 months, respectively, after switching therapy (all P<0.05). The mean percent decrease of IOP was 12.0%±13.0%, 14.5%±14.2%, 12.2%±18.7%, 16.0%±12.8%, and 12.8%±15.2% at 3, 6, 12, 24, and 36 months, respectively, after switching. Univariate or multivariate analysis revealed the percent decrease of IOP was associated with the type of glaucoma (POAG) at 3 and 12 months, and with the baseline IOP at 3, 12, 24, and 36 months. Kaplan–Meier analysis demonstrated that the percentage of patients who remained on treatment with DTFC was 94.7%, 94.7%, 84.2%, 78.9%, and 78.9% at 3, 6, 12, 24, and 36 months, respectively. Cox proportional hazards analysis showed that the type of glaucoma (POAG) was associated with an increased risk of failure to control the IOP.Conclusion: The IOP-lowering effect of DTFC was demonstrated for 3 years in this study. The baseline IOP had an important influence on the reduction of IOP achieved by DTFC. Keywords: switching treatment, glaucoma, Cox proportional hazards analysisTakeda SMimura TMatsubara MDove Medical PressarticleOphthalmologyRE1-994ENClinical Ophthalmology, Vol 2014, Iss default, Pp 1773-1782 (2014)
institution DOAJ
collection DOAJ
language EN
topic Ophthalmology
RE1-994
spellingShingle Ophthalmology
RE1-994
Takeda S
Mimura T
Matsubara M
Effect of 3 years of treatment with a dorzolamide/timolol (1%/0.5%) combination on intraocular pressure
description Sakurako Takeda,1,2 Tatsuya Mimura,1 Masao Matsubara1,2 1Department of Ophthalmology, Tokyo Women’s Medical University Medical Center East, Tokyo, Japan; 2Department of Ophthalmology, Nippori Clinic, Medical Center East, Tokyo Women’s Medical University, Tokyo, Japan Purpose: We aimed to evaluate the effect on the intraocular pressure (IOP) of a dorzolamide/timolol (1%/0.5%) fixed combination (DTFC) ophthalmic agent for 3 years.Participants: A total of 19 consecutive patients who had previously been treated with monotherapy or any combination of a beta-blocker, carbonic anhydrase inhibitor, or prostaglandin analog, for primary open-angle glaucoma (POAG) (n=5) or normal tension glaucoma (N=14) were enrolled.Methods: Patients were switched to DTFC from their prior glaucoma therapy. The IOP was measured at intervals of 4–6 weeks for 3 years. Treatment failure was defined as an increase of IOP by ≥10% from baseline after switching to DTFC.Results: The average IOP decreased significantly from 14.1±2.9 mmHg at baseline to 12.2±2.2, 11.8±2.4, 12.1±2.5, 11.6±1.8, and 12.1±2.7 mmHg at 3, 6, 12, 24, and 36 months, respectively, after switching therapy (all P<0.05). The mean percent decrease of IOP was 12.0%±13.0%, 14.5%±14.2%, 12.2%±18.7%, 16.0%±12.8%, and 12.8%±15.2% at 3, 6, 12, 24, and 36 months, respectively, after switching. Univariate or multivariate analysis revealed the percent decrease of IOP was associated with the type of glaucoma (POAG) at 3 and 12 months, and with the baseline IOP at 3, 12, 24, and 36 months. Kaplan–Meier analysis demonstrated that the percentage of patients who remained on treatment with DTFC was 94.7%, 94.7%, 84.2%, 78.9%, and 78.9% at 3, 6, 12, 24, and 36 months, respectively. Cox proportional hazards analysis showed that the type of glaucoma (POAG) was associated with an increased risk of failure to control the IOP.Conclusion: The IOP-lowering effect of DTFC was demonstrated for 3 years in this study. The baseline IOP had an important influence on the reduction of IOP achieved by DTFC. Keywords: switching treatment, glaucoma, Cox proportional hazards analysis
format article
author Takeda S
Mimura T
Matsubara M
author_facet Takeda S
Mimura T
Matsubara M
author_sort Takeda S
title Effect of 3 years of treatment with a dorzolamide/timolol (1%/0.5%) combination on intraocular pressure
title_short Effect of 3 years of treatment with a dorzolamide/timolol (1%/0.5%) combination on intraocular pressure
title_full Effect of 3 years of treatment with a dorzolamide/timolol (1%/0.5%) combination on intraocular pressure
title_fullStr Effect of 3 years of treatment with a dorzolamide/timolol (1%/0.5%) combination on intraocular pressure
title_full_unstemmed Effect of 3 years of treatment with a dorzolamide/timolol (1%/0.5%) combination on intraocular pressure
title_sort effect of 3 years of treatment with a dorzolamide/timolol (1%/0.5%) combination on intraocular pressure
publisher Dove Medical Press
publishDate 2014
url https://doaj.org/article/1c2616e1d1fe4efc9e2694525bd13395
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AT mimurat effectof3nbspyearsoftreatmentwithadorzolamidetimolol105combinationonintraocularpressure
AT matsubaram effectof3nbspyearsoftreatmentwithadorzolamidetimolol105combinationonintraocularpressure
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