Proteogenomic integration reveals therapeutic targets in breast cancer xenografts
Patient-derived xenografts recapitulate major genomic signatures and transcriptome profiles of their original tumours. Here, the authors, performing proteomic and phosphoproteomic analyses of 24 breast cancer PDX models, demonstrate that druggable candidates can be identified based on a comprehensiv...
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Nature Portfolio
2017
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oai:doaj.org-article:1c26a6238dc4471f89a26c07ab836e612021-12-02T14:41:07ZProteogenomic integration reveals therapeutic targets in breast cancer xenografts10.1038/ncomms148642041-1723https://doaj.org/article/1c26a6238dc4471f89a26c07ab836e612017-03-01T00:00:00Zhttps://doi.org/10.1038/ncomms14864https://doaj.org/toc/2041-1723Patient-derived xenografts recapitulate major genomic signatures and transcriptome profiles of their original tumours. Here, the authors, performing proteomic and phosphoproteomic analyses of 24 breast cancer PDX models, demonstrate that druggable candidates can be identified based on a comprehensive proteogenomic profiling.Kuan-lin HuangShunqiang LiPhilipp MertinsSong CaoHarsha P. GunawardenaKelly V. RugglesD. R. ManiKarl R. ClauserMaki TaniokaJerry UsaryShyam M. KavuriLing XieChristopher YoonJana W QiaoJohn WrobelMatthew A. WyczalkowskiPetra Erdmann-GilmoreJacqueline E. SniderJeremy HoogPurba SinghBeifang NiuZhanfang GuoSam Qiancheng SunSouzan SanatiEmily KawalerXuya WangAdam ScottKai YeMichael D. McLellanMichael C. WendlAnna MalovannayaJason M. HeldMichael A. GilletteDavid FenyöChristopher R. KinsingerMehdi MesriHenry RodriguezSherri R. DaviesCharles M. PerouCynthia MaR. Reid TownsendXian ChenSteven A. CarrMatthew J. EllisLi DingNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-17 (2017) |
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DOAJ |
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DOAJ |
| language |
EN |
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Science Q |
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Science Q Kuan-lin Huang Shunqiang Li Philipp Mertins Song Cao Harsha P. Gunawardena Kelly V. Ruggles D. R. Mani Karl R. Clauser Maki Tanioka Jerry Usary Shyam M. Kavuri Ling Xie Christopher Yoon Jana W Qiao John Wrobel Matthew A. Wyczalkowski Petra Erdmann-Gilmore Jacqueline E. Snider Jeremy Hoog Purba Singh Beifang Niu Zhanfang Guo Sam Qiancheng Sun Souzan Sanati Emily Kawaler Xuya Wang Adam Scott Kai Ye Michael D. McLellan Michael C. Wendl Anna Malovannaya Jason M. Held Michael A. Gillette David Fenyö Christopher R. Kinsinger Mehdi Mesri Henry Rodriguez Sherri R. Davies Charles M. Perou Cynthia Ma R. Reid Townsend Xian Chen Steven A. Carr Matthew J. Ellis Li Ding Proteogenomic integration reveals therapeutic targets in breast cancer xenografts |
| description |
Patient-derived xenografts recapitulate major genomic signatures and transcriptome profiles of their original tumours. Here, the authors, performing proteomic and phosphoproteomic analyses of 24 breast cancer PDX models, demonstrate that druggable candidates can be identified based on a comprehensive proteogenomic profiling. |
| format |
article |
| author |
Kuan-lin Huang Shunqiang Li Philipp Mertins Song Cao Harsha P. Gunawardena Kelly V. Ruggles D. R. Mani Karl R. Clauser Maki Tanioka Jerry Usary Shyam M. Kavuri Ling Xie Christopher Yoon Jana W Qiao John Wrobel Matthew A. Wyczalkowski Petra Erdmann-Gilmore Jacqueline E. Snider Jeremy Hoog Purba Singh Beifang Niu Zhanfang Guo Sam Qiancheng Sun Souzan Sanati Emily Kawaler Xuya Wang Adam Scott Kai Ye Michael D. McLellan Michael C. Wendl Anna Malovannaya Jason M. Held Michael A. Gillette David Fenyö Christopher R. Kinsinger Mehdi Mesri Henry Rodriguez Sherri R. Davies Charles M. Perou Cynthia Ma R. Reid Townsend Xian Chen Steven A. Carr Matthew J. Ellis Li Ding |
| author_facet |
Kuan-lin Huang Shunqiang Li Philipp Mertins Song Cao Harsha P. Gunawardena Kelly V. Ruggles D. R. Mani Karl R. Clauser Maki Tanioka Jerry Usary Shyam M. Kavuri Ling Xie Christopher Yoon Jana W Qiao John Wrobel Matthew A. Wyczalkowski Petra Erdmann-Gilmore Jacqueline E. Snider Jeremy Hoog Purba Singh Beifang Niu Zhanfang Guo Sam Qiancheng Sun Souzan Sanati Emily Kawaler Xuya Wang Adam Scott Kai Ye Michael D. McLellan Michael C. Wendl Anna Malovannaya Jason M. Held Michael A. Gillette David Fenyö Christopher R. Kinsinger Mehdi Mesri Henry Rodriguez Sherri R. Davies Charles M. Perou Cynthia Ma R. Reid Townsend Xian Chen Steven A. Carr Matthew J. Ellis Li Ding |
| author_sort |
Kuan-lin Huang |
| title |
Proteogenomic integration reveals therapeutic targets in breast cancer xenografts |
| title_short |
Proteogenomic integration reveals therapeutic targets in breast cancer xenografts |
| title_full |
Proteogenomic integration reveals therapeutic targets in breast cancer xenografts |
| title_fullStr |
Proteogenomic integration reveals therapeutic targets in breast cancer xenografts |
| title_full_unstemmed |
Proteogenomic integration reveals therapeutic targets in breast cancer xenografts |
| title_sort |
proteogenomic integration reveals therapeutic targets in breast cancer xenografts |
| publisher |
Nature Portfolio |
| publishDate |
2017 |
| url |
https://doaj.org/article/1c26a6238dc4471f89a26c07ab836e61 |
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