Alterations of microbiota structure in the larynx relevant to laryngeal carcinoma

Abstract The microbial communities that inhabit the laryngeal mucosa build stable microenvironments and have the potential to influence the health of the human throat. However, the associations between the microbiota structure and laryngeal carcinoma remain uncertain. Here, we explored this question...

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Autores principales:	Hongli Gong, Yi Shi, Xiyan Xiao, Pengyu Cao, Chunping Wu, Lei Tao, Dongsheng Hou, Yuezhu Wang, Liang Zhou
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/1c27e9f771654324bc794a462c993bd0
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spelling	oai:doaj.org-article:1c27e9f771654324bc794a462c993bd02021-12-02T12:32:12ZAlterations of microbiota structure in the larynx relevant to laryngeal carcinoma10.1038/s41598-017-05576-72045-2322https://doaj.org/article/1c27e9f771654324bc794a462c993bd02017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-05576-7https://doaj.org/toc/2045-2322Abstract The microbial communities that inhabit the laryngeal mucosa build stable microenvironments and have the potential to influence the health of the human throat. However, the associations between the microbiota structure and laryngeal carcinoma remain uncertain. Here, we explored this question by comparing the laryngeal microbiota structure in laryngeal cancer patients with that in control subjects with vocal cord polyps through high-throughput pyrosequencing. Overall, the genera Streptococcus, Fusobacterium, and Prevotella were prevalent bacterial populations in the laryngeal niche. Tumor tissue samples and normal tissues adjacent to the tumor sites (NATs) were collected from 31 laryngeal cancer patients, and the bacterial communities in laryngeal cancer patients were compared with control samples from 32 subjects. A comparison of the laryngeal communities in the tumor tissues and the NATs showed higher α-diversity in cancer patients than in control subjects, and the relative abundances of seven bacterial genera differed among the three groups of samples. Furthermore, the relative abundances of ten bacterial genera in laryngeal cancer patients differed substantially from those in control subjects. These findings indicate that the laryngeal microbiota profiles are altered in laryngeal cancer patients, suggesting that a disturbance of the microbiota structure might be relevant to laryngeal cancer.Hongli GongYi ShiXiyan XiaoPengyu CaoChunping WuLei TaoDongsheng HouYuezhu WangLiang ZhouNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Hongli Gong Yi Shi Xiyan Xiao Pengyu Cao Chunping Wu Lei Tao Dongsheng Hou Yuezhu Wang Liang Zhou Alterations of microbiota structure in the larynx relevant to laryngeal carcinoma
description	Abstract The microbial communities that inhabit the laryngeal mucosa build stable microenvironments and have the potential to influence the health of the human throat. However, the associations between the microbiota structure and laryngeal carcinoma remain uncertain. Here, we explored this question by comparing the laryngeal microbiota structure in laryngeal cancer patients with that in control subjects with vocal cord polyps through high-throughput pyrosequencing. Overall, the genera Streptococcus, Fusobacterium, and Prevotella were prevalent bacterial populations in the laryngeal niche. Tumor tissue samples and normal tissues adjacent to the tumor sites (NATs) were collected from 31 laryngeal cancer patients, and the bacterial communities in laryngeal cancer patients were compared with control samples from 32 subjects. A comparison of the laryngeal communities in the tumor tissues and the NATs showed higher α-diversity in cancer patients than in control subjects, and the relative abundances of seven bacterial genera differed among the three groups of samples. Furthermore, the relative abundances of ten bacterial genera in laryngeal cancer patients differed substantially from those in control subjects. These findings indicate that the laryngeal microbiota profiles are altered in laryngeal cancer patients, suggesting that a disturbance of the microbiota structure might be relevant to laryngeal cancer.
format	article
author	Hongli Gong Yi Shi Xiyan Xiao Pengyu Cao Chunping Wu Lei Tao Dongsheng Hou Yuezhu Wang Liang Zhou
author_facet	Hongli Gong Yi Shi Xiyan Xiao Pengyu Cao Chunping Wu Lei Tao Dongsheng Hou Yuezhu Wang Liang Zhou
author_sort	Hongli Gong
title	Alterations of microbiota structure in the larynx relevant to laryngeal carcinoma
title_short	Alterations of microbiota structure in the larynx relevant to laryngeal carcinoma
title_full	Alterations of microbiota structure in the larynx relevant to laryngeal carcinoma
title_fullStr	Alterations of microbiota structure in the larynx relevant to laryngeal carcinoma
title_full_unstemmed	Alterations of microbiota structure in the larynx relevant to laryngeal carcinoma
title_sort	alterations of microbiota structure in the larynx relevant to laryngeal carcinoma
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/1c27e9f771654324bc794a462c993bd0
work_keys_str_mv	AT hongligong alterationsofmicrobiotastructureinthelarynxrelevanttolaryngealcarcinoma AT yishi alterationsofmicrobiotastructureinthelarynxrelevanttolaryngealcarcinoma AT xiyanxiao alterationsofmicrobiotastructureinthelarynxrelevanttolaryngealcarcinoma AT pengyucao alterationsofmicrobiotastructureinthelarynxrelevanttolaryngealcarcinoma AT chunpingwu alterationsofmicrobiotastructureinthelarynxrelevanttolaryngealcarcinoma AT leitao alterationsofmicrobiotastructureinthelarynxrelevanttolaryngealcarcinoma AT dongshenghou alterationsofmicrobiotastructureinthelarynxrelevanttolaryngealcarcinoma AT yuezhuwang alterationsofmicrobiotastructureinthelarynxrelevanttolaryngealcarcinoma AT liangzhou alterationsofmicrobiotastructureinthelarynxrelevanttolaryngealcarcinoma
_version_	1718394144628408320

Alterations of microbiota structure in the larynx relevant to laryngeal carcinoma

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