Myelo-lymphoid lineage restriction occurs in the human haematopoietic stem cell compartment before lymphoid-primed multipotent progenitors

Human blood cells all develop from haematopoietic stem cells (HSCs), classically thought to be multipotent. Here the authors show, using single-cell RNA-seq and functional assays, that loss of erythroid potential and commitment to the myelo-lymphoid lineage occurs within the purest HSC compartment t...

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Autores principales:	Serena Belluschi, Emily F. Calderbank, Valerio Ciaurro, Blanca Pijuan-Sala, Antonella Santoro, Nicole Mende, Evangelia Diamanti, Kendig Yen Chi Sham, Xiaonan Wang, Winnie W. Y. Lau, Wajid Jawaid, Berthold Göttgens, Elisa Laurenti
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/1c2c1b37321a4167bfce7f9531b6a495
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spelling	oai:doaj.org-article:1c2c1b37321a4167bfce7f9531b6a4952021-12-02T14:39:26ZMyelo-lymphoid lineage restriction occurs in the human haematopoietic stem cell compartment before lymphoid-primed multipotent progenitors10.1038/s41467-018-06442-42041-1723https://doaj.org/article/1c2c1b37321a4167bfce7f9531b6a4952018-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06442-4https://doaj.org/toc/2041-1723Human blood cells all develop from haematopoietic stem cells (HSCs), classically thought to be multipotent. Here the authors show, using single-cell RNA-seq and functional assays, that loss of erythroid potential and commitment to the myelo-lymphoid lineage occurs within the purest HSC compartment to date.Serena BelluschiEmily F. CalderbankValerio CiaurroBlanca Pijuan-SalaAntonella SantoroNicole MendeEvangelia DiamantiKendig Yen Chi ShamXiaonan WangWinnie W. Y. LauWajid JawaidBerthold GöttgensElisa LaurentiNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Serena Belluschi Emily F. Calderbank Valerio Ciaurro Blanca Pijuan-Sala Antonella Santoro Nicole Mende Evangelia Diamanti Kendig Yen Chi Sham Xiaonan Wang Winnie W. Y. Lau Wajid Jawaid Berthold Göttgens Elisa Laurenti Myelo-lymphoid lineage restriction occurs in the human haematopoietic stem cell compartment before lymphoid-primed multipotent progenitors
description	Human blood cells all develop from haematopoietic stem cells (HSCs), classically thought to be multipotent. Here the authors show, using single-cell RNA-seq and functional assays, that loss of erythroid potential and commitment to the myelo-lymphoid lineage occurs within the purest HSC compartment to date.
format	article
author	Serena Belluschi Emily F. Calderbank Valerio Ciaurro Blanca Pijuan-Sala Antonella Santoro Nicole Mende Evangelia Diamanti Kendig Yen Chi Sham Xiaonan Wang Winnie W. Y. Lau Wajid Jawaid Berthold Göttgens Elisa Laurenti
author_facet	Serena Belluschi Emily F. Calderbank Valerio Ciaurro Blanca Pijuan-Sala Antonella Santoro Nicole Mende Evangelia Diamanti Kendig Yen Chi Sham Xiaonan Wang Winnie W. Y. Lau Wajid Jawaid Berthold Göttgens Elisa Laurenti
author_sort	Serena Belluschi
title	Myelo-lymphoid lineage restriction occurs in the human haematopoietic stem cell compartment before lymphoid-primed multipotent progenitors
title_short	Myelo-lymphoid lineage restriction occurs in the human haematopoietic stem cell compartment before lymphoid-primed multipotent progenitors
title_full	Myelo-lymphoid lineage restriction occurs in the human haematopoietic stem cell compartment before lymphoid-primed multipotent progenitors
title_fullStr	Myelo-lymphoid lineage restriction occurs in the human haematopoietic stem cell compartment before lymphoid-primed multipotent progenitors
title_full_unstemmed	Myelo-lymphoid lineage restriction occurs in the human haematopoietic stem cell compartment before lymphoid-primed multipotent progenitors
title_sort	myelo-lymphoid lineage restriction occurs in the human haematopoietic stem cell compartment before lymphoid-primed multipotent progenitors
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/1c2c1b37321a4167bfce7f9531b6a495
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Myelo-lymphoid lineage restriction occurs in the human haematopoietic stem cell compartment before lymphoid-primed multipotent progenitors

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