Recent developments in solid lipid nanoparticle and surface-modified solid lipid nanoparticle delivery systems for oral delivery of phyto-bioactive compounds in various chronic diseases

Palanivel Ganesan,1,2,* Prakash Ramalingam,3,4,* Govindarajan Karthivashan,1,* Young Tag Ko,4 Dong-Kug Choi1,2 1Department of Biotechnology, College of Biomedical and Health Science, Konkuk University, Chungju, Republic of Korea; 2Nanotechnology Research Center and Department of Applied Life Scienc...

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Autores principales:	Ganesan P, Ramalingam P, Karthivashan G, Ko YT, Choi DK
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	Solid-lipid nano particles surface-modified solid-lipid nanoparticles chronic diseases phyto-bioactive compounds chitosan Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/1c2c4fc35003450f9495ba02fb6daa45
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spelling	oai:doaj.org-article:1c2c4fc35003450f9495ba02fb6daa452021-12-02T04:20:41ZRecent developments in solid lipid nanoparticle and surface-modified solid lipid nanoparticle delivery systems for oral delivery of phyto-bioactive compounds in various chronic diseases1178-2013https://doaj.org/article/1c2c4fc35003450f9495ba02fb6daa452018-03-01T00:00:00Zhttps://www.dovepress.com/recent-developments-in-solid-lipid-nanoparticle-and-surface-modified-s-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Palanivel Ganesan,1,2,* Prakash Ramalingam,3,4,* Govindarajan Karthivashan,1,* Young Tag Ko,4 Dong-Kug Choi1,2 1Department of Biotechnology, College of Biomedical and Health Science, Konkuk University, Chungju, Republic of Korea; 2Nanotechnology Research Center and Department of Applied Life Science, Konkuk University, Chungju, Republic of Korea; 3Department of Pharmaceutical Sciences, Philadelphia College of Pharmacy, University of the Sciences, Philadelphia, PA, USA; 4College of Pharmacy, Gachon University, Incheon, Republic of Korea *These authors contributed equally to this work Abstract: Solid lipid nanoparticle (SLN) delivery systems have a wide applicability in the delivery of phyto-bioactive compounds to treat various chronic diseases, including diabetes, cancer, obesity and neurodegenerative diseases. The multiple benefits of SLN delivery include improved stability, smaller particle size, leaching prevention and enhanced lymphatic uptake of the bioactive compounds through oral delivery. However, the burst release makes the SLN delivery systems inadequate for the oral delivery of various phyto-bioactive compounds that can treat such chronic diseases. Recently, the surface-modified SLN (SMSLN) was observed to overcome this limitation for oral delivery of phyto-bioactive compounds, and there is growing evidence of an enhanced uptake of curcumin delivered orally via SMSLNs in the brain. This review focuses on different SLN and SMSLN systems that are useful for oral delivery of phyto-bioactive compounds to treat various chronic diseases. Keywords: solid lipid nanoparticles, surface-modified solid lipid nanoparticles, chronic diseases, phyto-bioactive compounds, chitosanGanesan PRamalingam PKarthivashan GKo YTChoi DKDove Medical PressarticleSolid-lipid nano particlessurface-modified solid-lipid nanoparticleschronic diseasesphyto-bioactive compoundschitosanMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 13, Pp 1569-1583 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Solid-lipid nano particles surface-modified solid-lipid nanoparticles chronic diseases phyto-bioactive compounds chitosan Medicine (General) R5-920
spellingShingle	Solid-lipid nano particles surface-modified solid-lipid nanoparticles chronic diseases phyto-bioactive compounds chitosan Medicine (General) R5-920 Ganesan P Ramalingam P Karthivashan G Ko YT Choi DK Recent developments in solid lipid nanoparticle and surface-modified solid lipid nanoparticle delivery systems for oral delivery of phyto-bioactive compounds in various chronic diseases
description	Palanivel Ganesan,1,2,* Prakash Ramalingam,3,4,* Govindarajan Karthivashan,1,* Young Tag Ko,4 Dong-Kug Choi1,2 1Department of Biotechnology, College of Biomedical and Health Science, Konkuk University, Chungju, Republic of Korea; 2Nanotechnology Research Center and Department of Applied Life Science, Konkuk University, Chungju, Republic of Korea; 3Department of Pharmaceutical Sciences, Philadelphia College of Pharmacy, University of the Sciences, Philadelphia, PA, USA; 4College of Pharmacy, Gachon University, Incheon, Republic of Korea *These authors contributed equally to this work Abstract: Solid lipid nanoparticle (SLN) delivery systems have a wide applicability in the delivery of phyto-bioactive compounds to treat various chronic diseases, including diabetes, cancer, obesity and neurodegenerative diseases. The multiple benefits of SLN delivery include improved stability, smaller particle size, leaching prevention and enhanced lymphatic uptake of the bioactive compounds through oral delivery. However, the burst release makes the SLN delivery systems inadequate for the oral delivery of various phyto-bioactive compounds that can treat such chronic diseases. Recently, the surface-modified SLN (SMSLN) was observed to overcome this limitation for oral delivery of phyto-bioactive compounds, and there is growing evidence of an enhanced uptake of curcumin delivered orally via SMSLNs in the brain. This review focuses on different SLN and SMSLN systems that are useful for oral delivery of phyto-bioactive compounds to treat various chronic diseases. Keywords: solid lipid nanoparticles, surface-modified solid lipid nanoparticles, chronic diseases, phyto-bioactive compounds, chitosan
format	article
author	Ganesan P Ramalingam P Karthivashan G Ko YT Choi DK
author_facet	Ganesan P Ramalingam P Karthivashan G Ko YT Choi DK
author_sort	Ganesan P
title	Recent developments in solid lipid nanoparticle and surface-modified solid lipid nanoparticle delivery systems for oral delivery of phyto-bioactive compounds in various chronic diseases
title_short	Recent developments in solid lipid nanoparticle and surface-modified solid lipid nanoparticle delivery systems for oral delivery of phyto-bioactive compounds in various chronic diseases
title_full	Recent developments in solid lipid nanoparticle and surface-modified solid lipid nanoparticle delivery systems for oral delivery of phyto-bioactive compounds in various chronic diseases
title_fullStr	Recent developments in solid lipid nanoparticle and surface-modified solid lipid nanoparticle delivery systems for oral delivery of phyto-bioactive compounds in various chronic diseases
title_full_unstemmed	Recent developments in solid lipid nanoparticle and surface-modified solid lipid nanoparticle delivery systems for oral delivery of phyto-bioactive compounds in various chronic diseases
title_sort	recent developments in solid lipid nanoparticle and surface-modified solid lipid nanoparticle delivery systems for oral delivery of phyto-bioactive compounds in various chronic diseases
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/1c2c4fc35003450f9495ba02fb6daa45
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Recent developments in solid lipid nanoparticle and surface-modified solid lipid nanoparticle delivery systems for oral delivery of phyto-bioactive compounds in various chronic diseases

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