The FRIABLE1 gene product affects cell adhesion in Arabidopsis.

Cell adhesion in plants is mediated predominantly by pectins, a group of complex cell wall associated polysaccharides. An Arabidopsis mutant, friable1 (frb1), was identified through a screen of T-DNA insertion lines that exhibited defective cell adhesion. Interestingly, the frb1 plants displayed bot...

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Autores principales:	Lutz Neumetzler, Tania Humphrey, Shelley Lumba, Stephen Snyder, Trevor H Yeats, Björn Usadel, Aleksandar Vasilevski, Jignasha Patel, Jocelyn K C Rose, Staffan Persson, Dario Bonetta
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/1c2c53edce53494cab4a57ae11456864
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spelling	oai:doaj.org-article:1c2c53edce53494cab4a57ae114568642021-11-18T07:08:44ZThe FRIABLE1 gene product affects cell adhesion in Arabidopsis.1932-620310.1371/journal.pone.0042914https://doaj.org/article/1c2c53edce53494cab4a57ae114568642012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22916179/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203Cell adhesion in plants is mediated predominantly by pectins, a group of complex cell wall associated polysaccharides. An Arabidopsis mutant, friable1 (frb1), was identified through a screen of T-DNA insertion lines that exhibited defective cell adhesion. Interestingly, the frb1 plants displayed both cell and organ dissociations and also ectopic defects in organ separation. The FRB1 gene encodes a Golgi-localized, plant specific protein with only weak sequence similarities to known proteins (DUF246). Unlike other cell adhesion deficient mutants, frb1 mutants do not have reduced levels of adhesion related cell wall polymers, such as pectins. Instead, FRB1 affects the abundance of galactose- and arabinose-containing oligosaccharides in the Golgi. Furthermore, frb1 mutants displayed alteration in pectin methylesterification, cell wall associated extensins and xyloglucan microstructure. We propose that abnormal FRB1 action has pleiotropic consequences on wall architecture, affecting both the extensin and pectin matrices, with consequent changes to the biomechanical properties of the wall and middle lamella, thereby influencing cell-cell adhesion.Lutz NeumetzlerTania HumphreyShelley LumbaStephen SnyderTrevor H YeatsBjörn UsadelAleksandar VasilevskiJignasha PatelJocelyn K C RoseStaffan PerssonDario BonettaPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 8, p e42914 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Lutz Neumetzler Tania Humphrey Shelley Lumba Stephen Snyder Trevor H Yeats Björn Usadel Aleksandar Vasilevski Jignasha Patel Jocelyn K C Rose Staffan Persson Dario Bonetta The FRIABLE1 gene product affects cell adhesion in Arabidopsis.
description	Cell adhesion in plants is mediated predominantly by pectins, a group of complex cell wall associated polysaccharides. An Arabidopsis mutant, friable1 (frb1), was identified through a screen of T-DNA insertion lines that exhibited defective cell adhesion. Interestingly, the frb1 plants displayed both cell and organ dissociations and also ectopic defects in organ separation. The FRB1 gene encodes a Golgi-localized, plant specific protein with only weak sequence similarities to known proteins (DUF246). Unlike other cell adhesion deficient mutants, frb1 mutants do not have reduced levels of adhesion related cell wall polymers, such as pectins. Instead, FRB1 affects the abundance of galactose- and arabinose-containing oligosaccharides in the Golgi. Furthermore, frb1 mutants displayed alteration in pectin methylesterification, cell wall associated extensins and xyloglucan microstructure. We propose that abnormal FRB1 action has pleiotropic consequences on wall architecture, affecting both the extensin and pectin matrices, with consequent changes to the biomechanical properties of the wall and middle lamella, thereby influencing cell-cell adhesion.
format	article
author	Lutz Neumetzler Tania Humphrey Shelley Lumba Stephen Snyder Trevor H Yeats Björn Usadel Aleksandar Vasilevski Jignasha Patel Jocelyn K C Rose Staffan Persson Dario Bonetta
author_facet	Lutz Neumetzler Tania Humphrey Shelley Lumba Stephen Snyder Trevor H Yeats Björn Usadel Aleksandar Vasilevski Jignasha Patel Jocelyn K C Rose Staffan Persson Dario Bonetta
author_sort	Lutz Neumetzler
title	The FRIABLE1 gene product affects cell adhesion in Arabidopsis.
title_short	The FRIABLE1 gene product affects cell adhesion in Arabidopsis.
title_full	The FRIABLE1 gene product affects cell adhesion in Arabidopsis.
title_fullStr	The FRIABLE1 gene product affects cell adhesion in Arabidopsis.
title_full_unstemmed	The FRIABLE1 gene product affects cell adhesion in Arabidopsis.
title_sort	friable1 gene product affects cell adhesion in arabidopsis.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/1c2c53edce53494cab4a57ae11456864
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The FRIABLE1 gene product affects cell adhesion in Arabidopsis.

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