CHANGES OF IMMUNE INDEXES DURING SUBLINGUAL ALLERGEN-SPECIFIC IMMUNOTHERAPY IN CHILDREN WITH HAY FEVER

Aims of study: evaluation of immunological parameters in course of sublingual allergen-specific immunotherapy with tree pollen mixture in children with hay fever.Materials and methods: the study included one-hundred patients 5 to 18 years of age with hay fever (pollen rhinitis, rhinoconjunctivitis a...

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Autores principales:	I. M. Gaiduk, D. S. Korostovtsev, N. L. Shaporova, D. V. Breykin, O. V. Trusova, I. A. Kamaeva
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	сублингвальная аллерген-специфическая иммунотерапия аллергический ринит бронхиальная астма цитокины дети Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/1c2c8340c2db4e2c91bbf07d82edf36e
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spelling	oai:doaj.org-article:1c2c8340c2db4e2c91bbf07d82edf36e2021-11-18T08:03:37ZCHANGES OF IMMUNE INDEXES DURING SUBLINGUAL ALLERGEN-SPECIFIC IMMUNOTHERAPY IN CHILDREN WITH HAY FEVER1563-06252313-741X10.15789/1563-0625-2013-1-51-54https://doaj.org/article/1c2c8340c2db4e2c91bbf07d82edf36e2014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/21https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XAims of study: evaluation of immunological parameters in course of sublingual allergen-specific immunotherapy with tree pollen mixture in children with hay fever.Materials and methods: the study included one-hundred patients 5 to 18 years of age with hay fever (pollen rhinitis, rhinoconjunctivitis and/or asthma). Allergen-specific immunotherapy was administered pre-seasonally for three consecutive years. Cytokinechanges were studied in blood serum and in lavages from nasal cavity. Samples assessed before treatment and after 2nd and 3rd courses SLIT completion.Results: increased serum concentrations of IL-10, IFNγ, and decreased IL-4 contents were revealed in the course of treatment. No significant changes in cytokineconcentrations were detectable in nasal lavages.Conclusions: the changes revealed correspond to a shift of T cell response profile towards Th1 pathway, thus confirming pathogenetic effects of sublingual allergen-specificI. M. GaidukD. S. KorostovtsevN. L. ShaporovaD. V. BreykinO. V. TrusovaI. A. KamaevaSPb RAACIarticleсублингвальная аллерген-специфическая иммунотерапияаллергический ринитбронхиальная астмацитокиныдетиImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 15, Iss 1, Pp 51-54 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	сублингвальная аллерген-специфическая иммунотерапия аллергический ринит бронхиальная астма цитокины дети Immunologic diseases. Allergy RC581-607
spellingShingle	сублингвальная аллерген-специфическая иммунотерапия аллергический ринит бронхиальная астма цитокины дети Immunologic diseases. Allergy RC581-607 I. M. Gaiduk D. S. Korostovtsev N. L. Shaporova D. V. Breykin O. V. Trusova I. A. Kamaeva CHANGES OF IMMUNE INDEXES DURING SUBLINGUAL ALLERGEN-SPECIFIC IMMUNOTHERAPY IN CHILDREN WITH HAY FEVER
description	Aims of study: evaluation of immunological parameters in course of sublingual allergen-specific immunotherapy with tree pollen mixture in children with hay fever.Materials and methods: the study included one-hundred patients 5 to 18 years of age with hay fever (pollen rhinitis, rhinoconjunctivitis and/or asthma). Allergen-specific immunotherapy was administered pre-seasonally for three consecutive years. Cytokinechanges were studied in blood serum and in lavages from nasal cavity. Samples assessed before treatment and after 2nd and 3rd courses SLIT completion.Results: increased serum concentrations of IL-10, IFNγ, and decreased IL-4 contents were revealed in the course of treatment. No significant changes in cytokineconcentrations were detectable in nasal lavages.Conclusions: the changes revealed correspond to a shift of T cell response profile towards Th1 pathway, thus confirming pathogenetic effects of sublingual allergen-specific
format	article
author	I. M. Gaiduk D. S. Korostovtsev N. L. Shaporova D. V. Breykin O. V. Trusova I. A. Kamaeva
author_facet	I. M. Gaiduk D. S. Korostovtsev N. L. Shaporova D. V. Breykin O. V. Trusova I. A. Kamaeva
author_sort	I. M. Gaiduk
title	CHANGES OF IMMUNE INDEXES DURING SUBLINGUAL ALLERGEN-SPECIFIC IMMUNOTHERAPY IN CHILDREN WITH HAY FEVER
title_short	CHANGES OF IMMUNE INDEXES DURING SUBLINGUAL ALLERGEN-SPECIFIC IMMUNOTHERAPY IN CHILDREN WITH HAY FEVER
title_full	CHANGES OF IMMUNE INDEXES DURING SUBLINGUAL ALLERGEN-SPECIFIC IMMUNOTHERAPY IN CHILDREN WITH HAY FEVER
title_fullStr	CHANGES OF IMMUNE INDEXES DURING SUBLINGUAL ALLERGEN-SPECIFIC IMMUNOTHERAPY IN CHILDREN WITH HAY FEVER
title_full_unstemmed	CHANGES OF IMMUNE INDEXES DURING SUBLINGUAL ALLERGEN-SPECIFIC IMMUNOTHERAPY IN CHILDREN WITH HAY FEVER
title_sort	changes of immune indexes during sublingual allergen-specific immunotherapy in children with hay fever
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/1c2c8340c2db4e2c91bbf07d82edf36e
work_keys_str_mv	AT imgaiduk changesofimmuneindexesduringsublingualallergenspecificimmunotherapyinchildrenwithhayfever AT dskorostovtsev changesofimmuneindexesduringsublingualallergenspecificimmunotherapyinchildrenwithhayfever AT nlshaporova changesofimmuneindexesduringsublingualallergenspecificimmunotherapyinchildrenwithhayfever AT dvbreykin changesofimmuneindexesduringsublingualallergenspecificimmunotherapyinchildrenwithhayfever AT ovtrusova changesofimmuneindexesduringsublingualallergenspecificimmunotherapyinchildrenwithhayfever AT iakamaeva changesofimmuneindexesduringsublingualallergenspecificimmunotherapyinchildrenwithhayfever
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CHANGES OF IMMUNE INDEXES DURING SUBLINGUAL ALLERGEN-SPECIFIC IMMUNOTHERAPY IN CHILDREN WITH HAY FEVER

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