Renoprotective Role of Hypoxia-Inducible Factors and the Mechanism

Background: The kidney requires abundant blood supply, and oxygen is transmitted by diffusion through blood vessels. Most physiological metabolism of the kidney depends on oxygen, so it is very sensitive to oxygen. An increasing pool of evidence suggests that hypoxia is involved in almost all acute...

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Autores principales:	Qiu-Yu Li, Fei Liu, Xiaoxiao Tang, Haidong Fu, Jianhua Mao
Formato:	article
Lenguaje:	EN
Publicado:	Karger Publishers 2021
Materias:	mechanism hypoxia-inducible factors hypoxia effect kidney disease Internal medicine RC31-1245
Acceso en línea:	https://doaj.org/article/1c31007bfb454d6e9f2752a581becc14
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spelling	oai:doaj.org-article:1c31007bfb454d6e9f2752a581becc142021-12-02T12:40:23ZRenoprotective Role of Hypoxia-Inducible Factors and the Mechanism2296-93812296-935710.1159/000520141https://doaj.org/article/1c31007bfb454d6e9f2752a581becc142021-11-01T00:00:00Zhttps://www.karger.com/Article/FullText/520141https://doaj.org/toc/2296-9381https://doaj.org/toc/2296-9357Background: The kidney requires abundant blood supply, and oxygen is transmitted by diffusion through blood vessels. Most physiological metabolism of the kidney depends on oxygen, so it is very sensitive to oxygen. An increasing pool of evidence suggests that hypoxia is involved in almost all acute and chronic kidney diseases (CKDs). Vascular damage, tubular injury, and fibrosis are the main pathologies associated during hypoxia. Hypoxia-inducible factors (HIFs) are the main mediators during hypoxia, but their functions remain controversial. This article reviewed recent studies and described its mechanisms on renoprotection. Summary: HIF is degraded rapidly during under normal oxygen. But under hypoxia, HIFs accumulate and many target genes are regulated by HIFs. Homeostasis during injury is maintained through these genes. Pretreatment of HIF can protect the kidney from acute hypoxia and can improve repair, but HIF’s role in CKD and in renal tumor is still controversial. Due to its mechanism in kidney disease, many drugs toward HIFs are widely researched, even some of which have been used in clinical or in clinical research. Key Messages: In this review, we described the known physiological mechanisms, target genes, and renal protective roles of HIFs, and we discussed several drugs that are researched due to such renal protective roles.Qiu-Yu LiFei LiuXiaoxiao TangHaidong FuJianhua MaoKarger Publishersarticlemechanismhypoxia-inducible factorshypoxiaeffectkidney diseaseInternal medicineRC31-1245ENKidney Diseases, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	mechanism hypoxia-inducible factors hypoxia effect kidney disease Internal medicine RC31-1245
spellingShingle	mechanism hypoxia-inducible factors hypoxia effect kidney disease Internal medicine RC31-1245 Qiu-Yu Li Fei Liu Xiaoxiao Tang Haidong Fu Jianhua Mao Renoprotective Role of Hypoxia-Inducible Factors and the Mechanism
description	Background: The kidney requires abundant blood supply, and oxygen is transmitted by diffusion through blood vessels. Most physiological metabolism of the kidney depends on oxygen, so it is very sensitive to oxygen. An increasing pool of evidence suggests that hypoxia is involved in almost all acute and chronic kidney diseases (CKDs). Vascular damage, tubular injury, and fibrosis are the main pathologies associated during hypoxia. Hypoxia-inducible factors (HIFs) are the main mediators during hypoxia, but their functions remain controversial. This article reviewed recent studies and described its mechanisms on renoprotection. Summary: HIF is degraded rapidly during under normal oxygen. But under hypoxia, HIFs accumulate and many target genes are regulated by HIFs. Homeostasis during injury is maintained through these genes. Pretreatment of HIF can protect the kidney from acute hypoxia and can improve repair, but HIF’s role in CKD and in renal tumor is still controversial. Due to its mechanism in kidney disease, many drugs toward HIFs are widely researched, even some of which have been used in clinical or in clinical research. Key Messages: In this review, we described the known physiological mechanisms, target genes, and renal protective roles of HIFs, and we discussed several drugs that are researched due to such renal protective roles.
format	article
author	Qiu-Yu Li Fei Liu Xiaoxiao Tang Haidong Fu Jianhua Mao
author_facet	Qiu-Yu Li Fei Liu Xiaoxiao Tang Haidong Fu Jianhua Mao
author_sort	Qiu-Yu Li
title	Renoprotective Role of Hypoxia-Inducible Factors and the Mechanism
title_short	Renoprotective Role of Hypoxia-Inducible Factors and the Mechanism
title_full	Renoprotective Role of Hypoxia-Inducible Factors and the Mechanism
title_fullStr	Renoprotective Role of Hypoxia-Inducible Factors and the Mechanism
title_full_unstemmed	Renoprotective Role of Hypoxia-Inducible Factors and the Mechanism
title_sort	renoprotective role of hypoxia-inducible factors and the mechanism
publisher	Karger Publishers
publishDate	2021
url	https://doaj.org/article/1c31007bfb454d6e9f2752a581becc14
work_keys_str_mv	AT qiuyuli renoprotectiveroleofhypoxiainduciblefactorsandthemechanism AT feiliu renoprotectiveroleofhypoxiainduciblefactorsandthemechanism AT xiaoxiaotang renoprotectiveroleofhypoxiainduciblefactorsandthemechanism AT haidongfu renoprotectiveroleofhypoxiainduciblefactorsandthemechanism AT jianhuamao renoprotectiveroleofhypoxiainduciblefactorsandthemechanism
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Renoprotective Role of Hypoxia-Inducible Factors and the Mechanism

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