The protective immunity induced by SARS-CoV-2 infection and vaccination: a critical appraisal

Understanding the interactions of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) with humans is deeply grounded in immunology, from the diagnosis to pathogenesis, from the clinical presentations to the epidemiology, prevention, and treatment. However, the difficulty of capturing the co...

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Autor principal:	Eduardo Tosta
Formato:	article
Lenguaje:	EN
Publicado:	Open Exploration Publishing Inc. 2021
Materias:	protective immunity sars-cov-2 infection sars-cov-2 vaccines susceptibility specificity immunological memory epitope selection adaptation permissive immunity Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/1c3193c362a7410c89d15d21c4655de0
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spelling	oai:doaj.org-article:1c3193c362a7410c89d15d21c4655de02021-11-24T06:17:02ZThe protective immunity induced by SARS-CoV-2 infection and vaccination: a critical appraisal10.37349/ei.2021.000142768-6655https://doaj.org/article/1c3193c362a7410c89d15d21c4655de02021-08-01T00:00:00Zhttps://www.explorationpub.com/Journals/ei/Article/100314https://doaj.org/toc/2768-6655Understanding the interactions of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) with humans is deeply grounded in immunology, from the diagnosis to pathogenesis, from the clinical presentations to the epidemiology, prevention, and treatment. However, the difficulty of capturing the complex and changeable array of immunological concepts and incorporating them into the strategies of control of the SARS-CoV-2 pandemic poses significant hindrances to establish optimal public health policies. The contribution of immunology to the control of the pandemic is to shed light on the features and mechanisms of the protective immunity elicited by SARS-CoV-2 infection and vaccines. Do they induce effective protective immunity? How? For how long? What is the effect of vaccination on individuals who were previously infected? To appropriately answer these questions, it is necessary to get rid of the outdated notion of a naïve, static, and closed immune system, which leads to misconceptions about susceptibility, specificity, immunological memory, and protective immunity. The present essay discusses these issues based on current immunological concepts.Eduardo TostaOpen Exploration Publishing Inc.articleprotective immunitysars-cov-2 infectionsars-cov-2 vaccinessusceptibilityspecificityimmunological memoryepitope selectionadaptationpermissive immunityImmunologic diseases. AllergyRC581-607ENExploration of Immunology, Vol 1, Iss 3, Pp 199-225 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	protective immunity sars-cov-2 infection sars-cov-2 vaccines susceptibility specificity immunological memory epitope selection adaptation permissive immunity Immunologic diseases. Allergy RC581-607
spellingShingle	protective immunity sars-cov-2 infection sars-cov-2 vaccines susceptibility specificity immunological memory epitope selection adaptation permissive immunity Immunologic diseases. Allergy RC581-607 Eduardo Tosta The protective immunity induced by SARS-CoV-2 infection and vaccination: a critical appraisal
description	Understanding the interactions of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) with humans is deeply grounded in immunology, from the diagnosis to pathogenesis, from the clinical presentations to the epidemiology, prevention, and treatment. However, the difficulty of capturing the complex and changeable array of immunological concepts and incorporating them into the strategies of control of the SARS-CoV-2 pandemic poses significant hindrances to establish optimal public health policies. The contribution of immunology to the control of the pandemic is to shed light on the features and mechanisms of the protective immunity elicited by SARS-CoV-2 infection and vaccines. Do they induce effective protective immunity? How? For how long? What is the effect of vaccination on individuals who were previously infected? To appropriately answer these questions, it is necessary to get rid of the outdated notion of a naïve, static, and closed immune system, which leads to misconceptions about susceptibility, specificity, immunological memory, and protective immunity. The present essay discusses these issues based on current immunological concepts.
format	article
author	Eduardo Tosta
author_facet	Eduardo Tosta
author_sort	Eduardo Tosta
title	The protective immunity induced by SARS-CoV-2 infection and vaccination: a critical appraisal
title_short	The protective immunity induced by SARS-CoV-2 infection and vaccination: a critical appraisal
title_full	The protective immunity induced by SARS-CoV-2 infection and vaccination: a critical appraisal
title_fullStr	The protective immunity induced by SARS-CoV-2 infection and vaccination: a critical appraisal
title_full_unstemmed	The protective immunity induced by SARS-CoV-2 infection and vaccination: a critical appraisal
title_sort	protective immunity induced by sars-cov-2 infection and vaccination: a critical appraisal
publisher	Open Exploration Publishing Inc.
publishDate	2021
url	https://doaj.org/article/1c3193c362a7410c89d15d21c4655de0
work_keys_str_mv	AT eduardotosta theprotectiveimmunityinducedbysarscov2infectionandvaccinationacriticalappraisal AT eduardotosta protectiveimmunityinducedbysarscov2infectionandvaccinationacriticalappraisal
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The protective immunity induced by SARS-CoV-2 infection and vaccination: a critical appraisal

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