An Outlook on Global Regulatory Landscape for Genome-Edited Crops

The revolutionary technology of CRISPR/Cas systems and their extraordinary potential to address fundamental questions in every field of biological sciences has led to their developers being awarded the 2020 Nobel Prize for Chemistry. In agriculture, CRISPR/Cas systems have accelerated the developmen...

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Autores principales:	Aftab Ahmad, Nayla Munawar, Zulqurnain Khan, Alaa T. Qusmani, Sultan Habibullah Khan, Amer Jamil, Sidra Ashraf, Muhammad Zubair Ghouri, Sabin Aslam, Muhammad Salman Mubarik, Ahmad Munir, Qaiser Sultan, Kamel A. Abd-Elsalam, Sameer H. Qari
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	genome editing 2 CRISPR/Cas 3 global regulations 4 CRISPR crops Biology (General) QH301-705.5 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/1c32240dc1e64ccba82ce5e370dec8d3
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id	oai:doaj.org-article:1c32240dc1e64ccba82ce5e370dec8d3
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spelling	oai:doaj.org-article:1c32240dc1e64ccba82ce5e370dec8d32021-11-11T17:13:38ZAn Outlook on Global Regulatory Landscape for Genome-Edited Crops10.3390/ijms2221117531422-00671661-6596https://doaj.org/article/1c32240dc1e64ccba82ce5e370dec8d32021-10-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/21/11753https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-0067The revolutionary technology of CRISPR/Cas systems and their extraordinary potential to address fundamental questions in every field of biological sciences has led to their developers being awarded the 2020 Nobel Prize for Chemistry. In agriculture, CRISPR/Cas systems have accelerated the development of new crop varieties with improved traits—without the need for transgenes. However, the future of this technology depends on a clear and truly global regulatory framework being developed for these crops. Some CRISPR-edited crops are already on the market, and yet countries and regions are still divided over their legal status. CRISPR editing does not require transgenes, making CRISPR crops more socially acceptable than genetically modified crops, but there is vigorous debate over how to regulate these crops and what precautionary measures are required before they appear on the market. This article reviews intended outcomes and risks arising from the site-directed nuclease CRISPR systems used to improve agricultural crop plant genomes. It examines how various CRISPR system components, and potential concerns associated with CRISPR/Cas, may trigger regulatory oversight of CRISPR-edited crops. The article highlights differences and similarities between GMOs and CRISPR-edited crops, and discusses social and ethical concerns. It outlines the regulatory framework for GMO crops, which many countries also apply to CRISPR-edited crops, and the global regulatory landscape for CRISPR-edited crops. The article concludes with future prospects for CRISPR-edited crops and their products.Aftab AhmadNayla MunawarZulqurnain KhanAlaa T. QusmaniSultan Habibullah KhanAmer JamilSidra AshrafMuhammad Zubair GhouriSabin AslamMuhammad Salman MubarikAhmad MunirQaiser SultanKamel A. Abd-ElsalamSameer H. QariMDPI AGarticlegenome editing 2CRISPR/Cas 3global regulations 4CRISPR cropsBiology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 11753, p 11753 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	genome editing 2 CRISPR/Cas 3 global regulations 4 CRISPR crops Biology (General) QH301-705.5 Chemistry QD1-999
spellingShingle	genome editing 2 CRISPR/Cas 3 global regulations 4 CRISPR crops Biology (General) QH301-705.5 Chemistry QD1-999 Aftab Ahmad Nayla Munawar Zulqurnain Khan Alaa T. Qusmani Sultan Habibullah Khan Amer Jamil Sidra Ashraf Muhammad Zubair Ghouri Sabin Aslam Muhammad Salman Mubarik Ahmad Munir Qaiser Sultan Kamel A. Abd-Elsalam Sameer H. Qari An Outlook on Global Regulatory Landscape for Genome-Edited Crops
description	The revolutionary technology of CRISPR/Cas systems and their extraordinary potential to address fundamental questions in every field of biological sciences has led to their developers being awarded the 2020 Nobel Prize for Chemistry. In agriculture, CRISPR/Cas systems have accelerated the development of new crop varieties with improved traits—without the need for transgenes. However, the future of this technology depends on a clear and truly global regulatory framework being developed for these crops. Some CRISPR-edited crops are already on the market, and yet countries and regions are still divided over their legal status. CRISPR editing does not require transgenes, making CRISPR crops more socially acceptable than genetically modified crops, but there is vigorous debate over how to regulate these crops and what precautionary measures are required before they appear on the market. This article reviews intended outcomes and risks arising from the site-directed nuclease CRISPR systems used to improve agricultural crop plant genomes. It examines how various CRISPR system components, and potential concerns associated with CRISPR/Cas, may trigger regulatory oversight of CRISPR-edited crops. The article highlights differences and similarities between GMOs and CRISPR-edited crops, and discusses social and ethical concerns. It outlines the regulatory framework for GMO crops, which many countries also apply to CRISPR-edited crops, and the global regulatory landscape for CRISPR-edited crops. The article concludes with future prospects for CRISPR-edited crops and their products.
format	article
author	Aftab Ahmad Nayla Munawar Zulqurnain Khan Alaa T. Qusmani Sultan Habibullah Khan Amer Jamil Sidra Ashraf Muhammad Zubair Ghouri Sabin Aslam Muhammad Salman Mubarik Ahmad Munir Qaiser Sultan Kamel A. Abd-Elsalam Sameer H. Qari
author_facet	Aftab Ahmad Nayla Munawar Zulqurnain Khan Alaa T. Qusmani Sultan Habibullah Khan Amer Jamil Sidra Ashraf Muhammad Zubair Ghouri Sabin Aslam Muhammad Salman Mubarik Ahmad Munir Qaiser Sultan Kamel A. Abd-Elsalam Sameer H. Qari
author_sort	Aftab Ahmad
title	An Outlook on Global Regulatory Landscape for Genome-Edited Crops
title_short	An Outlook on Global Regulatory Landscape for Genome-Edited Crops
title_full	An Outlook on Global Regulatory Landscape for Genome-Edited Crops
title_fullStr	An Outlook on Global Regulatory Landscape for Genome-Edited Crops
title_full_unstemmed	An Outlook on Global Regulatory Landscape for Genome-Edited Crops
title_sort	outlook on global regulatory landscape for genome-edited crops
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/1c32240dc1e64ccba82ce5e370dec8d3
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An Outlook on Global Regulatory Landscape for Genome-Edited Crops

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