Deep Brain Stimulation of the Forel’s Field for Dystonia: Preliminary Results

The field of Forel (FF) is a subthalamic area through which the pallidothalamic tracts originating from the globus pallidus internus (GPi) traverse. The FF was used as a stereotactic surgical target (ablation and stimulation) to treat cervical dystonia in the 1960s and 1970s. Although recent studies...

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Autores principales:	Shiro Horisawa, Kotaro Kohara, Masato Murakami, Atsushi Fukui, Takakazu Kawamata, Takaomi Taira
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	Forel’s field pallidothalamic tract deep brain stimulation dystonia globus pallidus internus Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Acceso en línea:	https://doaj.org/article/1c324d7105a5452ba1e555a9308248e3
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spelling	oai:doaj.org-article:1c324d7105a5452ba1e555a9308248e32021-12-01T13:29:01ZDeep Brain Stimulation of the Forel’s Field for Dystonia: Preliminary Results1662-516110.3389/fnhum.2021.768057https://doaj.org/article/1c324d7105a5452ba1e555a9308248e32021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fnhum.2021.768057/fullhttps://doaj.org/toc/1662-5161The field of Forel (FF) is a subthalamic area through which the pallidothalamic tracts originating from the globus pallidus internus (GPi) traverse. The FF was used as a stereotactic surgical target (ablation and stimulation) to treat cervical dystonia in the 1960s and 1970s. Although recent studies have reappraised the ablation and stimulation of the pallidothalamic tract at FF for Parkinson’s disease, the efficacy of deep brain stimulation of FF (FF-DBS) for dystonia has not been well investigated. To confirm the efficacy and stimulation-induced adverse effects of FF-DBS, three consecutive patients with medically refractory dystonia who underwent FF-DBS were analyzed (tongue protrusion dystonia, cranio-cervico-axial dystonia, and hemidystonia). Compared to the Burke-Fahn-Marsden Dystonia Rating Scale-Movement Scale scores before surgery (23.3 ± 12.7), improvements were observed at 1 week (8.3 ± 5.9), 3 months (5.3 ± 5.9), and 6 months (4.7 ± 4.7, p = 0.0282) after surgery. Two patients had stimulation-induced complications, including bradykinesia and postural instability, all well controlled by stimulation adjustments.Shiro HorisawaKotaro KoharaMasato MurakamiAtsushi FukuiTakakazu KawamataTakaomi TairaFrontiers Media S.A.articleForel’s fieldpallidothalamic tractdeep brain stimulationdystoniaglobus pallidus internusNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENFrontiers in Human Neuroscience, Vol 15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Forel’s field pallidothalamic tract deep brain stimulation dystonia globus pallidus internus Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
spellingShingle	Forel’s field pallidothalamic tract deep brain stimulation dystonia globus pallidus internus Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Shiro Horisawa Kotaro Kohara Masato Murakami Atsushi Fukui Takakazu Kawamata Takaomi Taira Deep Brain Stimulation of the Forel’s Field for Dystonia: Preliminary Results
description	The field of Forel (FF) is a subthalamic area through which the pallidothalamic tracts originating from the globus pallidus internus (GPi) traverse. The FF was used as a stereotactic surgical target (ablation and stimulation) to treat cervical dystonia in the 1960s and 1970s. Although recent studies have reappraised the ablation and stimulation of the pallidothalamic tract at FF for Parkinson’s disease, the efficacy of deep brain stimulation of FF (FF-DBS) for dystonia has not been well investigated. To confirm the efficacy and stimulation-induced adverse effects of FF-DBS, three consecutive patients with medically refractory dystonia who underwent FF-DBS were analyzed (tongue protrusion dystonia, cranio-cervico-axial dystonia, and hemidystonia). Compared to the Burke-Fahn-Marsden Dystonia Rating Scale-Movement Scale scores before surgery (23.3 ± 12.7), improvements were observed at 1 week (8.3 ± 5.9), 3 months (5.3 ± 5.9), and 6 months (4.7 ± 4.7, p = 0.0282) after surgery. Two patients had stimulation-induced complications, including bradykinesia and postural instability, all well controlled by stimulation adjustments.
format	article
author	Shiro Horisawa Kotaro Kohara Masato Murakami Atsushi Fukui Takakazu Kawamata Takaomi Taira
author_facet	Shiro Horisawa Kotaro Kohara Masato Murakami Atsushi Fukui Takakazu Kawamata Takaomi Taira
author_sort	Shiro Horisawa
title	Deep Brain Stimulation of the Forel’s Field for Dystonia: Preliminary Results
title_short	Deep Brain Stimulation of the Forel’s Field for Dystonia: Preliminary Results
title_full	Deep Brain Stimulation of the Forel’s Field for Dystonia: Preliminary Results
title_fullStr	Deep Brain Stimulation of the Forel’s Field for Dystonia: Preliminary Results
title_full_unstemmed	Deep Brain Stimulation of the Forel’s Field for Dystonia: Preliminary Results
title_sort	deep brain stimulation of the forel’s field for dystonia: preliminary results
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/1c324d7105a5452ba1e555a9308248e3
work_keys_str_mv	AT shirohorisawa deepbrainstimulationoftheforelsfieldfordystoniapreliminaryresults AT kotarokohara deepbrainstimulationoftheforelsfieldfordystoniapreliminaryresults AT masatomurakami deepbrainstimulationoftheforelsfieldfordystoniapreliminaryresults AT atsushifukui deepbrainstimulationoftheforelsfieldfordystoniapreliminaryresults AT takakazukawamata deepbrainstimulationoftheforelsfieldfordystoniapreliminaryresults AT takaomitaira deepbrainstimulationoftheforelsfieldfordystoniapreliminaryresults
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Deep Brain Stimulation of the Forel’s Field for Dystonia: Preliminary Results

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