The systemic inflammatory landscape of COVID-19 in pregnancy: Extensive serum proteomic profiling of mother-infant dyads with in utero SARS-CoV-2
Summary: While pregnancy increases the risk for severe COVID-19, the clinical and immunological implications of COVID-19 on maternal-fetal health remain unknown. Here, we present the clinical and immunological landscapes of 93 COVID-19 mothers and 45 of their SARS-CoV-2-exposed infants through compr...
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Elsevier
2021
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oai:doaj.org-article:1c324e793bc94b928f2734eeaf0120662021-11-18T04:52:18ZThe systemic inflammatory landscape of COVID-19 in pregnancy: Extensive serum proteomic profiling of mother-infant dyads with in utero SARS-CoV-22666-379110.1016/j.xcrm.2021.100453https://doaj.org/article/1c324e793bc94b928f2734eeaf0120662021-11-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2666379121003219https://doaj.org/toc/2666-3791Summary: While pregnancy increases the risk for severe COVID-19, the clinical and immunological implications of COVID-19 on maternal-fetal health remain unknown. Here, we present the clinical and immunological landscapes of 93 COVID-19 mothers and 45 of their SARS-CoV-2-exposed infants through comprehensive serum proteomics profiling for >1,400 cytokines of their peripheral and cord blood specimens. Prenatal SARS-CoV-2 infection triggers NF-κB-dependent proinflammatory immune activation. Pregnant women with severe COVID-19 show increased inflammation and unique IFN-λ antiviral signaling, with elevated levels of IFNL1 and IFNLR1. Furthermore, SARS-CoV-2 infection re-shapes maternal immunity at delivery, altering the expression of pregnancy complication-associated cytokines, inducing MMP7, MDK, and ESM1 and reducing BGN and CD209. Finally, COVID-19-exposed infants exhibit induction of T cell-associated cytokines (IL33, NFATC3, and CCL21), while some undergo IL-1β/IL-18/CASP1 axis-driven neonatal respiratory distress despite birth at term. Our findings demonstrate COVID-19-induced immune rewiring in both mothers and neonates, warranting long-term clinical follow-up to mitigate potential health risks.Suan-Sin FooMary Catherine CambouThalia MokViviana M. FajardoKyle L. JungTrevon FullerWeiqiang ChenTara KerinJenny MeiDebika BhattacharyaYounho ChoiXin WuTian XiaWoo-Jin ShinJessica CranstonGrace AldrovandiNicole TobinDeisy ContrerasFrancisco J. IbarrondoOtto YangShangxin YangOmai GarnerRuth CortadoYvonne BrysonCarla JanzenShubhamoy GhoshSherin DevaskarBrenda AsilnejadMaria Elisabeth MoreiraZilton VasconcelosPriya R. SoniL. Caroline GibsonPatricia BrasilSuzy A.A. ComhairVaithilingaraja ArumugaswamiSerpil C. ErzurumRashmi RaoJae U. JungKarin Nielsen-SainesElsevierarticleCOVID-19pregnancyprenatal SARS-CoV-2 infectionmother-infant pairsserum proteomicsCOVID-19-exposed infantsMedicine (General)R5-920ENCell Reports Medicine, Vol 2, Iss 11, Pp 100453- (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
COVID-19 pregnancy prenatal SARS-CoV-2 infection mother-infant pairs serum proteomics COVID-19-exposed infants Medicine (General) R5-920 |
| spellingShingle |
COVID-19 pregnancy prenatal SARS-CoV-2 infection mother-infant pairs serum proteomics COVID-19-exposed infants Medicine (General) R5-920 Suan-Sin Foo Mary Catherine Cambou Thalia Mok Viviana M. Fajardo Kyle L. Jung Trevon Fuller Weiqiang Chen Tara Kerin Jenny Mei Debika Bhattacharya Younho Choi Xin Wu Tian Xia Woo-Jin Shin Jessica Cranston Grace Aldrovandi Nicole Tobin Deisy Contreras Francisco J. Ibarrondo Otto Yang Shangxin Yang Omai Garner Ruth Cortado Yvonne Bryson Carla Janzen Shubhamoy Ghosh Sherin Devaskar Brenda Asilnejad Maria Elisabeth Moreira Zilton Vasconcelos Priya R. Soni L. Caroline Gibson Patricia Brasil Suzy A.A. Comhair Vaithilingaraja Arumugaswami Serpil C. Erzurum Rashmi Rao Jae U. Jung Karin Nielsen-Saines The systemic inflammatory landscape of COVID-19 in pregnancy: Extensive serum proteomic profiling of mother-infant dyads with in utero SARS-CoV-2 |
| description |
Summary: While pregnancy increases the risk for severe COVID-19, the clinical and immunological implications of COVID-19 on maternal-fetal health remain unknown. Here, we present the clinical and immunological landscapes of 93 COVID-19 mothers and 45 of their SARS-CoV-2-exposed infants through comprehensive serum proteomics profiling for >1,400 cytokines of their peripheral and cord blood specimens. Prenatal SARS-CoV-2 infection triggers NF-κB-dependent proinflammatory immune activation. Pregnant women with severe COVID-19 show increased inflammation and unique IFN-λ antiviral signaling, with elevated levels of IFNL1 and IFNLR1. Furthermore, SARS-CoV-2 infection re-shapes maternal immunity at delivery, altering the expression of pregnancy complication-associated cytokines, inducing MMP7, MDK, and ESM1 and reducing BGN and CD209. Finally, COVID-19-exposed infants exhibit induction of T cell-associated cytokines (IL33, NFATC3, and CCL21), while some undergo IL-1β/IL-18/CASP1 axis-driven neonatal respiratory distress despite birth at term. Our findings demonstrate COVID-19-induced immune rewiring in both mothers and neonates, warranting long-term clinical follow-up to mitigate potential health risks. |
| format |
article |
| author |
Suan-Sin Foo Mary Catherine Cambou Thalia Mok Viviana M. Fajardo Kyle L. Jung Trevon Fuller Weiqiang Chen Tara Kerin Jenny Mei Debika Bhattacharya Younho Choi Xin Wu Tian Xia Woo-Jin Shin Jessica Cranston Grace Aldrovandi Nicole Tobin Deisy Contreras Francisco J. Ibarrondo Otto Yang Shangxin Yang Omai Garner Ruth Cortado Yvonne Bryson Carla Janzen Shubhamoy Ghosh Sherin Devaskar Brenda Asilnejad Maria Elisabeth Moreira Zilton Vasconcelos Priya R. Soni L. Caroline Gibson Patricia Brasil Suzy A.A. Comhair Vaithilingaraja Arumugaswami Serpil C. Erzurum Rashmi Rao Jae U. Jung Karin Nielsen-Saines |
| author_facet |
Suan-Sin Foo Mary Catherine Cambou Thalia Mok Viviana M. Fajardo Kyle L. Jung Trevon Fuller Weiqiang Chen Tara Kerin Jenny Mei Debika Bhattacharya Younho Choi Xin Wu Tian Xia Woo-Jin Shin Jessica Cranston Grace Aldrovandi Nicole Tobin Deisy Contreras Francisco J. Ibarrondo Otto Yang Shangxin Yang Omai Garner Ruth Cortado Yvonne Bryson Carla Janzen Shubhamoy Ghosh Sherin Devaskar Brenda Asilnejad Maria Elisabeth Moreira Zilton Vasconcelos Priya R. Soni L. Caroline Gibson Patricia Brasil Suzy A.A. Comhair Vaithilingaraja Arumugaswami Serpil C. Erzurum Rashmi Rao Jae U. Jung Karin Nielsen-Saines |
| author_sort |
Suan-Sin Foo |
| title |
The systemic inflammatory landscape of COVID-19 in pregnancy: Extensive serum proteomic profiling of mother-infant dyads with in utero SARS-CoV-2 |
| title_short |
The systemic inflammatory landscape of COVID-19 in pregnancy: Extensive serum proteomic profiling of mother-infant dyads with in utero SARS-CoV-2 |
| title_full |
The systemic inflammatory landscape of COVID-19 in pregnancy: Extensive serum proteomic profiling of mother-infant dyads with in utero SARS-CoV-2 |
| title_fullStr |
The systemic inflammatory landscape of COVID-19 in pregnancy: Extensive serum proteomic profiling of mother-infant dyads with in utero SARS-CoV-2 |
| title_full_unstemmed |
The systemic inflammatory landscape of COVID-19 in pregnancy: Extensive serum proteomic profiling of mother-infant dyads with in utero SARS-CoV-2 |
| title_sort |
systemic inflammatory landscape of covid-19 in pregnancy: extensive serum proteomic profiling of mother-infant dyads with in utero sars-cov-2 |
| publisher |
Elsevier |
| publishDate |
2021 |
| url |
https://doaj.org/article/1c324e793bc94b928f2734eeaf012066 |
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