Circulating level of miR-378 predicts left ventricular hypertrophy in patients with aortic stenosis.

<h4>Aims</h4>Excessively high left ventricle mass is an independent predictor of adverse prognosis. MicroRNAs (miRs) play crucial roles in the regulation of left ventricle hypertrophy (LVH). However, few circulating miRs have been established as predictors of LVH in aortic stenosis (AS)...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Zhongxiu Chen, Chen Li, Yuanning Xu, Yajiao Li, Hao Yang, Li Rao
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/1c35ebe038ca447d808b03155458cb58
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:1c35ebe038ca447d808b03155458cb58
record_format	dspace
spelling	oai:doaj.org-article:1c35ebe038ca447d808b03155458cb582021-11-25T06:03:12ZCirculating level of miR-378 predicts left ventricular hypertrophy in patients with aortic stenosis.1932-620310.1371/journal.pone.0105702https://doaj.org/article/1c35ebe038ca447d808b03155458cb582014-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0105702https://doaj.org/toc/1932-6203<h4>Aims</h4>Excessively high left ventricle mass is an independent predictor of adverse prognosis. MicroRNAs (miRs) play crucial roles in the regulation of left ventricle hypertrophy (LVH). However, few circulating miRs have been established as predictors of LVH in aortic stenosis (AS) patients. In this study, we aimed to investigate whether circulating levels of miR-1, miR-133, and miR-378 predict LVH in patients with AS.<h4>Methods and results</h4>One-hundred twelve patients with moderate to severe AS and 40 healthy controls were included in the study. Levels of miR-1, miR-133, and miR-378 in the plasma were measured by qPCR. Compared with healthy controls, AS patients had significantly lower circulating levels of miR-1, miR-133, and miR-378. AS patients with LVH had significantly lower miR-378 but not miR-1 and miR-133 compared with those without LVH. Linear regression analysis showed circulating miR-378 had strong correlation with left ventricular mass index (r = 0.283, p = 0.002) and logistic regression showed that lower miR-378 was an independent predictor for LVH in patients with AS (p = 0.037, OR 4.110, 95% CI 1.086 to 15.558).<h4>Conclusion</h4>Circulating levels of miR-1, miR-133 and miR-378 were decreased in AS patients, and miR-378 predicts LVH independent of the pressure gradient. Further prospective investigations are needed to elucidate whether these circulating miRs affect clinical outcome.Zhongxiu ChenChen LiYuanning XuYajiao LiHao YangLi RaoPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 8, p e105702 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Zhongxiu Chen Chen Li Yuanning Xu Yajiao Li Hao Yang Li Rao Circulating level of miR-378 predicts left ventricular hypertrophy in patients with aortic stenosis.
description	<h4>Aims</h4>Excessively high left ventricle mass is an independent predictor of adverse prognosis. MicroRNAs (miRs) play crucial roles in the regulation of left ventricle hypertrophy (LVH). However, few circulating miRs have been established as predictors of LVH in aortic stenosis (AS) patients. In this study, we aimed to investigate whether circulating levels of miR-1, miR-133, and miR-378 predict LVH in patients with AS.<h4>Methods and results</h4>One-hundred twelve patients with moderate to severe AS and 40 healthy controls were included in the study. Levels of miR-1, miR-133, and miR-378 in the plasma were measured by qPCR. Compared with healthy controls, AS patients had significantly lower circulating levels of miR-1, miR-133, and miR-378. AS patients with LVH had significantly lower miR-378 but not miR-1 and miR-133 compared with those without LVH. Linear regression analysis showed circulating miR-378 had strong correlation with left ventricular mass index (r = 0.283, p = 0.002) and logistic regression showed that lower miR-378 was an independent predictor for LVH in patients with AS (p = 0.037, OR 4.110, 95% CI 1.086 to 15.558).<h4>Conclusion</h4>Circulating levels of miR-1, miR-133 and miR-378 were decreased in AS patients, and miR-378 predicts LVH independent of the pressure gradient. Further prospective investigations are needed to elucidate whether these circulating miRs affect clinical outcome.
format	article
author	Zhongxiu Chen Chen Li Yuanning Xu Yajiao Li Hao Yang Li Rao
author_facet	Zhongxiu Chen Chen Li Yuanning Xu Yajiao Li Hao Yang Li Rao
author_sort	Zhongxiu Chen
title	Circulating level of miR-378 predicts left ventricular hypertrophy in patients with aortic stenosis.
title_short	Circulating level of miR-378 predicts left ventricular hypertrophy in patients with aortic stenosis.
title_full	Circulating level of miR-378 predicts left ventricular hypertrophy in patients with aortic stenosis.
title_fullStr	Circulating level of miR-378 predicts left ventricular hypertrophy in patients with aortic stenosis.
title_full_unstemmed	Circulating level of miR-378 predicts left ventricular hypertrophy in patients with aortic stenosis.
title_sort	circulating level of mir-378 predicts left ventricular hypertrophy in patients with aortic stenosis.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/1c35ebe038ca447d808b03155458cb58
work_keys_str_mv	AT zhongxiuchen circulatinglevelofmir378predictsleftventricularhypertrophyinpatientswithaorticstenosis AT chenli circulatinglevelofmir378predictsleftventricularhypertrophyinpatientswithaorticstenosis AT yuanningxu circulatinglevelofmir378predictsleftventricularhypertrophyinpatientswithaorticstenosis AT yajiaoli circulatinglevelofmir378predictsleftventricularhypertrophyinpatientswithaorticstenosis AT haoyang circulatinglevelofmir378predictsleftventricularhypertrophyinpatientswithaorticstenosis AT lirao circulatinglevelofmir378predictsleftventricularhypertrophyinpatientswithaorticstenosis
_version_	1718414209455226880

Circulating level of miR-378 predicts left ventricular hypertrophy in patients with aortic stenosis.

Ejemplares similares