RBFOX2 is critical for maintaining alternative polyadenylation patterns and mitochondrial health in rat myoblasts

RBFOX2 is critical for maintaining alternative polyadenylation patterns and mitochondrial health in rat myoblasts

Summary: RBFOX2, which has a well-established role in alternative splicing, is linked to heart diseases. However, it is unclear whether RBFOX2 has other roles in RNA processing that can influence gene expression in muscle cells, contributing to heart disease. Here, we employ both 3ʹ-end and nanopore...

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Main Authors: Jun Cao, Sunil K. Verma, Elizabeth Jaworski, Stephanie Mohan, Chloe K. Nagasawa, Kempaiah Rayavara, Amanda Sooter, Sierra N. Miller, Richard J. Holcomb, Mason J. Powell, Ping Ji, Nathan D. Elrod, Eda Yildirim, Eric J. Wagner, Vsevolod Popov, Nisha J. Garg, Andrew L. Routh, Muge N. Kuyumcu-Martinez
Format: article
Language:EN
Published: Elsevier 2021
Subjects:
RBFOX2
alternative polyadenylation
mitochondria
Slc25a4
Tropomyosin 1
nanopore sequencing
Biology (General)
QH301-705.5
Online Access:https://doaj.org/article/1c3849ba190a44869afb25b4370a9f1a
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https://doaj.org/article/1c3849ba190a44869afb25b4370a9f1a

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