p38-MK2 signaling axis regulates RNA metabolism after UV-light-induced DNA damage

UV-light-induced DNA damage affects RNA metabolism but the underlying signalling pathways are largely unexplored. Here, the authors show that UV light triggers p38-MK2-mediated phosphorylation of the NELF complex, promoting its release from chromatin and concurrent transcriptional elongation.

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Autores principales:	Marina E. Borisova, Andrea Voigt, Maxim A. X. Tollenaere, Sanjeeb Kumar Sahu, Thomas Juretschke, Nastasja Kreim, Niels Mailand, Chunaram Choudhary, Simon Bekker-Jensen, Masato Akutsu, Sebastian A. Wagner, Petra Beli
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/1c38a6be3fea435e8a20721ee3302833
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spelling	oai:doaj.org-article:1c38a6be3fea435e8a20721ee33028332021-12-02T15:34:23Zp38-MK2 signaling axis regulates RNA metabolism after UV-light-induced DNA damage10.1038/s41467-018-03417-32041-1723https://doaj.org/article/1c38a6be3fea435e8a20721ee33028332018-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03417-3https://doaj.org/toc/2041-1723UV-light-induced DNA damage affects RNA metabolism but the underlying signalling pathways are largely unexplored. Here, the authors show that UV light triggers p38-MK2-mediated phosphorylation of the NELF complex, promoting its release from chromatin and concurrent transcriptional elongation.Marina E. BorisovaAndrea VoigtMaxim A. X. TollenaereSanjeeb Kumar SahuThomas JuretschkeNastasja KreimNiels MailandChunaram ChoudharySimon Bekker-JensenMasato AkutsuSebastian A. WagnerPetra BeliNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Marina E. Borisova Andrea Voigt Maxim A. X. Tollenaere Sanjeeb Kumar Sahu Thomas Juretschke Nastasja Kreim Niels Mailand Chunaram Choudhary Simon Bekker-Jensen Masato Akutsu Sebastian A. Wagner Petra Beli p38-MK2 signaling axis regulates RNA metabolism after UV-light-induced DNA damage
description	UV-light-induced DNA damage affects RNA metabolism but the underlying signalling pathways are largely unexplored. Here, the authors show that UV light triggers p38-MK2-mediated phosphorylation of the NELF complex, promoting its release from chromatin and concurrent transcriptional elongation.
format	article
author	Marina E. Borisova Andrea Voigt Maxim A. X. Tollenaere Sanjeeb Kumar Sahu Thomas Juretschke Nastasja Kreim Niels Mailand Chunaram Choudhary Simon Bekker-Jensen Masato Akutsu Sebastian A. Wagner Petra Beli
author_facet	Marina E. Borisova Andrea Voigt Maxim A. X. Tollenaere Sanjeeb Kumar Sahu Thomas Juretschke Nastasja Kreim Niels Mailand Chunaram Choudhary Simon Bekker-Jensen Masato Akutsu Sebastian A. Wagner Petra Beli
author_sort	Marina E. Borisova
title	p38-MK2 signaling axis regulates RNA metabolism after UV-light-induced DNA damage
title_short	p38-MK2 signaling axis regulates RNA metabolism after UV-light-induced DNA damage
title_full	p38-MK2 signaling axis regulates RNA metabolism after UV-light-induced DNA damage
title_fullStr	p38-MK2 signaling axis regulates RNA metabolism after UV-light-induced DNA damage
title_full_unstemmed	p38-MK2 signaling axis regulates RNA metabolism after UV-light-induced DNA damage
title_sort	p38-mk2 signaling axis regulates rna metabolism after uv-light-induced dna damage
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/1c38a6be3fea435e8a20721ee3302833
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p38-MK2 signaling axis regulates RNA metabolism after UV-light-induced DNA damage

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