CXCL12 and MYC control energy metabolism to support adaptive responses after kidney injury
Injuries in the embryonal kidney can be repaired by a cell migratory response but how this is regulated at a molecular level is unclear. Here, the authors show in mice that deletion of Cxcl12 and Myc delays pronephros injury repair by changing mitochondrial metabolism and glycolysis.
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Nature Portfolio
2018
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oai:doaj.org-article:1c3d2a42e5234ad3afafeb44b9152fbb2021-12-02T14:38:50ZCXCL12 and MYC control energy metabolism to support adaptive responses after kidney injury10.1038/s41467-018-06094-42041-1723https://doaj.org/article/1c3d2a42e5234ad3afafeb44b9152fbb2018-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06094-4https://doaj.org/toc/2041-1723Injuries in the embryonal kidney can be repaired by a cell migratory response but how this is regulated at a molecular level is unclear. Here, the authors show in mice that deletion of Cxcl12 and Myc delays pronephros injury repair by changing mitochondrial metabolism and glycolysis.Toma A. YakulovAbhijeet P. TodkarKrasimir SlanchevJohannes WiegelAlexandra BonaMartin GroßAlexander ScholzIsabell HessAnne WurditschFlorian GrahammerTobias B. HuberVirginie LecaudeyTillmann BorkJochen HochreinMelanie BoerriesJustine LeendersPascal de TullioFrançois JouretAlbrecht Kramer-ZuckerGerd WalzNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-15 (2018) |
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DOAJ |
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DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Toma A. Yakulov Abhijeet P. Todkar Krasimir Slanchev Johannes Wiegel Alexandra Bona Martin Groß Alexander Scholz Isabell Hess Anne Wurditsch Florian Grahammer Tobias B. Huber Virginie Lecaudey Tillmann Bork Jochen Hochrein Melanie Boerries Justine Leenders Pascal de Tullio François Jouret Albrecht Kramer-Zucker Gerd Walz CXCL12 and MYC control energy metabolism to support adaptive responses after kidney injury |
| description |
Injuries in the embryonal kidney can be repaired by a cell migratory response but how this is regulated at a molecular level is unclear. Here, the authors show in mice that deletion of Cxcl12 and Myc delays pronephros injury repair by changing mitochondrial metabolism and glycolysis. |
| format |
article |
| author |
Toma A. Yakulov Abhijeet P. Todkar Krasimir Slanchev Johannes Wiegel Alexandra Bona Martin Groß Alexander Scholz Isabell Hess Anne Wurditsch Florian Grahammer Tobias B. Huber Virginie Lecaudey Tillmann Bork Jochen Hochrein Melanie Boerries Justine Leenders Pascal de Tullio François Jouret Albrecht Kramer-Zucker Gerd Walz |
| author_facet |
Toma A. Yakulov Abhijeet P. Todkar Krasimir Slanchev Johannes Wiegel Alexandra Bona Martin Groß Alexander Scholz Isabell Hess Anne Wurditsch Florian Grahammer Tobias B. Huber Virginie Lecaudey Tillmann Bork Jochen Hochrein Melanie Boerries Justine Leenders Pascal de Tullio François Jouret Albrecht Kramer-Zucker Gerd Walz |
| author_sort |
Toma A. Yakulov |
| title |
CXCL12 and MYC control energy metabolism to support adaptive responses after kidney injury |
| title_short |
CXCL12 and MYC control energy metabolism to support adaptive responses after kidney injury |
| title_full |
CXCL12 and MYC control energy metabolism to support adaptive responses after kidney injury |
| title_fullStr |
CXCL12 and MYC control energy metabolism to support adaptive responses after kidney injury |
| title_full_unstemmed |
CXCL12 and MYC control energy metabolism to support adaptive responses after kidney injury |
| title_sort |
cxcl12 and myc control energy metabolism to support adaptive responses after kidney injury |
| publisher |
Nature Portfolio |
| publishDate |
2018 |
| url |
https://doaj.org/article/1c3d2a42e5234ad3afafeb44b9152fbb |
| work_keys_str_mv |
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| _version_ |
1718390816864468992 |